Husband and wife with sarcoidosis: possible environmental factors involved
© Leli et al; licensee BioMed Central Ltd. 2013
Received: 8 November 2012
Accepted: 2 January 2013
Published: 25 January 2013
Sarcoidosis is a granulomatous multisystem disorder of unclear etiology that involves any organ, most commonly the lung and the lymph nodes. It is hypothesized that the disease derives from the interaction between single or multiple environmental factors and genetically determined host factors. Multiple potential etiologic agents for sarcoidosis have been proposed without any definitive demonstration of causality.
We report the case of two patients, husband (57 years old) and wife (55 years old), both suffering from sarcoidosis. They underwent a lymph node biopsy by mediastinoscopy which showed a “granulomatous epithelioid giant cell non-necrotising chronic lymphadenitis”. They had lived up to 3 years ago in the country in a farm, in contact with organic dusts, animals such as dogs, chickens, rabbits, pigeons; now they have lived since about 3 years in an urban area where there are numerous chemical industries and stone quarries. The aim of this case report was to focus on environmental factors that might be related to the pathogenesis of the sarcoidosis.
KeywordsEnvironmental factors Granuloma Sarcoidosis
Sarcoidosis is a granulomatous multisystem disorder of unclear etiology that involves any organ, most commonly the lung and the intrathoracic lymph nodes. Also heart, skin, and central nervous system are frequently affected. The diagnosis of sarcoidosis is further hindered by the lack of any reliable and specific diagnostic test, as there are no laboratory or imaging findings that enable the definitive diagnosis. Even the histological data are not conclusive because the non-necrotising granuloma, a hallmark of morphologic appearance of the disease, is not unique for sarcoidosis. Granulomas typically consist of a compact central area of macrophages that differentiate into epithelioid cells and then fuse to form multinucleated giant cells surrounded by lymphocytes.
A genetic predisposition to sarcoidosis is epidemiologically evidenced by the demonstration of familial aggregation, differences in disease susceptibility and severity between racial groups, and the significantly increased incidence in monozygotic twins of affected individuals compared to other siblings [1, 2]. It is hypothesized that the disease derives from the interaction between single or multiple environmental factors and genetically determined host factors. Multiple potential etiologic agents for sarcoidosis have been proposed without any definitive demonstration of causality. However, environmental causes of sarcoidosis or sarcoidosis-like granulomatous diseases are well established, especially after industrial exposure to beryllium . An enduring hypothesis is that based on an infectious etiology, with Mycobacterium spp. being the most commonly implicated organism. The role of various non-infectious organic and inorganic environmental agents has been studied in the pathogenesis of sarcoidosis.
We report the case of two patients, husband and wife who had lived up to 3 years ago in the open country, in contact with organic dusts (hay and molds), and animals such as dogs, chickens, rabbits, pigeons; now they live in an urban area where there are numerous chemicals industries and stone quarries.
Respiratory function results in the woman
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Respiratory function results in the man
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The environmental exposition of the two patients concerns chemical agents because of the industries near where they lived in the last years and because of the presence of a sand quarry. The industries in the area where they live include those involved in the processing of tires. Thus, factors such as the inorganic powder used in the rubber industry can play an active role in the pathogenesis of their disease. Other factors potentially involved could be silica, silicone and the fibers of the glass. Three recent longitudinal studies regarding the World Trade Center disaster have emphasized the role of airborne inorganic particulate exposure in sarcoidosis [4–6]. These studies showed an increase in sarcoidosis among firefighters and emergency first responders. Jordan et al.  followed World Trade Center health registry participants, including 43 patients with sarcoidosis confirmed on clinical and histological basis. They stratified individuals in their cohort based on self-reported dust cloud exposures and observed that a more intensive rescue and recovery activities was related to an increased risk of disease . Additionally, Crowley et al.  calculated an extraordinarily high annual incidence rate of 229 cases of sarcoidosis per 100,000 person-years, based on a record review of nearly 20,000 individuals in the World Trade Center medical surveillance program. The World Trade Center dust was a highly alkaline mixture that the US Geological Survey characterized as containing mostly the components of concrete, including gypsum, anhydrite, and manmade vitreous fibers. These epidemiological studies do not demonstrate the components or the mechanisms by which this dust triggers granuloma formation. However, taken as a whole, this body of literature on World Trade Center sarcoidosis helps to validate the case series and case reports of the last decades reporting sarcoidosis occurring after exposure to silica, talc, and other inorganic triggers.
Geographic clustering of disease in the southern United States and in other parts of the world has promoted further speculations concerning weather, soil, and foliage in the pathogenesis of sarcoidosis . Past studies have noted high prevalence of sarcoidosis where there is lumbering activity and exposure to farm animals and pets . Rural residence, birthplace or time spent in rural regions have been associated with sarcoidosis . Cummings et al.  observed clustering in communities with lumbering or wood milling as the principal local industry.
Interestingly, other studies suggest the hypothesis of either a person-to-person transmission or a shared exposure to an environmental agent. In a well documented clustering that has occurred in the relatively isolated population of the Isle of Man, individuals with sarcoidosis were more likely to have had prior contact with an individual who had sarcoidosis, compared to controls (39.6% versus 1.1%). These contacts included neighbors, unrelated cohabitants, and co-workers . Similarly, there has been a cluster of cases among sisters and unrelated social contacts, including one sister’s employer . Although familial clustering may be explained on the basis of shared genes, shared common environmental exposures must be considered as well.
Finally, several observations suggest that sarcoidosis may be caused by an infectious agent. There are many known infectious agents that can cause granulomas that resemble those of sarcoidosis, including mycobacteria, herpes viruses, histoplasmosis, treponematosis, sporotrichosis, coccidioidomycosis, schistosomiasis, listeria, the agent of Whipple’s disease and Rhodococcussp. Because sarcoidosis has a world-wide distribution, it is necessary to postulate that the putative agent that causes sarcoidosis is also widely distributed. However, it is also possible that sarcoidosis may be the result of several different infections. A real problem in identifying an etiologic agent causing sarcoidosis is its wide variety of clinical manifestations, which derives from the complex immunologic processes underlying the disease.
Both our patients have got labial herpes simplex virus and this could suggest a potential role of the infection in the development of the disease. Moreover, before moving to the urban area, the two patients lived in the countryside, reporting exposure to molds and hay. Finally, they were exposed to chemical agents derived from the industry of the tires. Among those, silica is a mix of modern tires and it is known that silica could be potentially involved in the pathogenesis of the disease. However, all the environmental factors that could be considered potential triggers of the disease are not sufficient by themselves to cause sarcoidosis and must interact with a particular immune response of the host. Therefore, the genetic predisposition of the patients plays a key role in the development and progression of the disease.
In conclusion, this case report wants to focus on environmental factors that may be potential causative agents for sarcoidosis. Important tool in investigating patients with sarcoidosis is a complete medical history that includes occupational and environmental factors, lifestyle habits and any previous infection. It could be also useful to study and monitor the areas with the highest incidence of this disease.
Written informed consent was obtained from the patient for publication of this Case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Rybicki BA, Iannuzzi MC, Frederick MM, Thompson BW, Rossman MD, Bresnitz EA, Terrin ML, Moller DR, Barnard J, Baughman RP, DePalo L, Hunninghake G, Johns C, Judson MA, Knatterud GL, McLennan G, Newman LS, Rabin DL, Rose C, Teirstein AS, Weinberger SE, Yeager H, Cherniack R, ACCESS Research Group: Familial aggregation of sarcoidosis. A case–control etiologic study of sarcoidosis (ACCESS). Am J Respir Crit Care Med. 2001, 164 (11): 2085-2091.View ArticlePubMedGoogle Scholar
- Sverrild A, Backer V, Kyvik KO, Kaprio J, Milman N, Svendsen CB, Thomsen SF: Heredity in sarcoidosis: a registry-based twin study. Thorax. 2008, 63 (10): 894-896. 10.1136/thx.2007.094060.View ArticlePubMedGoogle Scholar
- Culver DA, Newman LS, Kavuru MS: Gene environment interactions in sarcoidosis: challenge and opportunity. Clin Dermatol. 2007, 25: 267-275. 10.1016/j.clindermatol.2007.03.005.PubMed CentralView ArticlePubMedGoogle Scholar
- Jordan HT, Stellman SD, Prezant D, Teirstein A, Osahan SS, Cone JE: Sarcoidosis diagnosed after September 11, 2001, among adults exposed to the World Trade Center disaster. J Occup Environ Med. 2011, 53: 966-974. 10.1097/JOM.0b013e31822a3596.View ArticlePubMedGoogle Scholar
- Bowers B, Hasni S, Gruber BL: Sarcoidosis in World Trade Center rescue workers presenting with rheumatologic manifestations. J Clin Rheumatol. 2010, 16: 26-27. 10.1097/RHU.0b013e3181c78856.View ArticlePubMedGoogle Scholar
- Crowley LE, Herbert R, Moline JM, Wallenstein S, Shukla G, Schechter C, Skloot GS, Udasin I, Luft BJ, Harrison D, Shapiro M, Wong K, Sacks HS, Landrigan PJ, Teirstein AS: ‘Sarcoid like’ granulomatous pulmonary disease in World Trade Center disaster responders. Am J Ind Med. 2011, 54: 175-184. 10.1002/ajim.20924.View ArticlePubMedGoogle Scholar
- Sartwell PE, Edwards LB: Epidemiology of sarcoidosis in the U.S. Navy. Am J Epidemiol. 1974, 99: 250-257.PubMedGoogle Scholar
- Buck AA: Epidemiologic investigators of sarcoidosis. IV. Discussion and summary. Am J Hyg. 1961, 74: 189-202.PubMedGoogle Scholar
- Cummings MM, Dunner E, Williams JH: Epidemiologic and clinical observations in sarcoidosis. Ann Intern Med. 1959, 50: 879-890.View ArticlePubMedGoogle Scholar
- Parkes SA, Baker SB, Bourdillon RE, Murray CR, Rakshit M, Sarkies JW, Travers JP, Williams EW: Incidence of sarcoidosis in the Isle of Man. Thorax. 1985, 40: 284-287. 10.1136/thx.40.4.284.PubMed CentralView ArticlePubMedGoogle Scholar
- Stewart IC, Davidson NM: Clustering of sarcoidosis. Thorax. 1982, 37: 398-399. 10.1136/thx.37.5.398.PubMed CentralView ArticlePubMedGoogle Scholar
- Popper HH, Winter E, Hofler G: DNA of mycobacterium tuberculosis in formalin-fixed, paraffin-embedded tissue in tuberculosis and sarcoidosis detected by polymerase chain reaction. Am J Clin Pathol. 1994, 101: 738-741.PubMedGoogle Scholar
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