Treating severe allergic asthma with anti-IgE monoclonal antibody (omalizumab): a review
© D’Amato et al.; licensee BioMed Central Ltd. 2014
Received: 30 August 2013
Accepted: 1 April 2014
Published: 15 April 2014
Increased asthma severity is not only associated with enhanced recurrent hospitalization and mortality but also with higher social costs.
Several cases of asthma are atopic in nature, with the trigger for acute asthma attacks and chronic worsening of inflammation being allergens inducing an immune, IgE mediated response.
Anti-inflammatory treatments are effective for most of asthma patients, but there are subjects whose disease is incompletely controlled by inhaled or systemic corticosteroids and these patients account for about 50% of the healthcare costs of asthma.
Omalizumab is a biological engineered, humanized recombinant monoclonal anti-IgE antibody developed for the treatment of allergic diseases and with clear efficacy in adolescent and adult patients with severe allergic asthma. The anti-IgE antibody inhibits IgE functions blocking free serum IgE and inhibiting their binding to cellular receptors. By reducing serum IgE levels and IgE receptor expression on inflammatory cells in the context of allergic cascade, omalizumab has demonstrated to be a very useful treatment of atopic asthma, improving quality of life of patients with severe persistent allergic asthma that is inadequately controlled by currently available asthma medications. Several trials have demonstrated that this therapy is well tolerated and significantly improves symptoms and disease control, reducing asthma exacerbations and the need to use high dosage of inhaled corticosteroids.
KeywordsAllergic asthma Allergic respiratory diseases Anti-IgE therapy Monoclonal anti-IgE antibody Omalizumab Therapy of asthma Urticaria
A body of evidence suggests that bronchial asthma and other allergic diseases have become more common worldwide in recent years and are recognized as a higly prevalent health problem in the developed and developing world [1–6]. It is estimated that more than 50% of asthma has an allergic background and about 50% of patients with severe asthma have allergic-atopic asthma [2, 6], although many previously published data demonstrated that the severe phenotype is less frequent in atopic adult-onset asthma [6–8].
It is well known that immunoglobulin E (IgE) antibodies, Th2 derived cytokines and eosinophils play a major role in the development of chronic airway inflammation, which is observed even in subjects with mild disease [9–12]. Airway inflammation plays a central role in the pathogenesis of bronchial asthma and is associated with an increase in airway responsiveness to several trigger factors such as aeroallergens which induce bronchoconstriction in atopic asthma patients, acting sometimes in cooperation with other trigger factors such as viruses and air pollution.
The development of inflammation in asthma involves a complex array of several inflammatory mediators that promote the recruitment and activation of various different immune cells and regulate inflammatory cell trafficking into the lungs.
Activation of chemokine receptors triggers multiple cascades of intracellular signaling events that lead to recruitment and activation of immune effector cells. The inhibition of specific chemokines and receptors could prevent the excessive recruitment of leukocytes to sites of inflammation.
Elevated serum levels of specific IgE towards common environmental allergens are a key component in the pathogenesis of allergic asthma. IgE antibodies cause chronic airway inflammation through effector cells such as mastcells, basophils etc, activated via high-affinity (FcϵRI) or low-affinity (FcϵRII) IgE receptors.
Current treatment for asthma suggested by Global Initiative for Asthma (GINA) guidelines includes several reliever and controller drugs, in particular corticosteroids which reduce recruitment and activation of inflammatory cells in the airways . The available anti-asthma treatments are effective for most of these patients. However, there are asthmatic subjects who continue to experience severe debilitating disease, since their bronco-obstruction is incompletely controlled by inhaled or systemic corticosteroids associated with other drugs such as beta-2 agonist bronchodilators (short and long-acting), antileukotrienes etc. Moreover, increased asthma severity is not only associated with enhanced recurrent hospitalisation and mortality within one year of initial hospitalisation, but also with higher economical and social costs .
IgE antibodies have been viewed as a target for immunological drug development in asthma, and a number of strategies aimed at inhibiting its proinflammatory action have been developed, despite an increase in recent years in the availability of drugs used for asthma therapy.
Mechanisms of action of omalizumab
Therapeutic anti-IgE antibodies, omalizumab, able to reduce free IgE levels avoiding the binding of IgE to Fcϵ RI and the following development of allergic reaction (crosslinking IgE and triggering degranulation and syntesis of new-generated chemical mediators of IgE-sensitized cells) are now widely used in the therapy of allergic bronchial asthma [15–34]. This anti-IgE monoclonal antibody (omalizumab) binds IgE at the same site of Fc fragment defined Cϵ3 domain as these antibodies bind Fcϵ RI and FcϵRII. Consequently, IgE effector functions are inhibited, because the IgE binding to high-affinity receptors on IgE effector cells is blocked, as well as the following activation of mast cells and basophils [15–35]. In other words, in allergic subjects omalizumab prevents the activation of cellular response and the occurrence of asthma symptoms. Omalizumab expresses a high degree of isotype specificity and can neutralize serum free IgE without affecting other antibody classes.
Studies in patients with atopic asthma showed that anti-IgE antibodies decrease serum IgE levels in a dose-dependent manner and allergen-induced bronchoconstriction during both the early and late-phase responses to inhaled allergen [18–20].
Serum free IgE are rapidly reduced after omalizumab administration and the expression of high-affinity receptors is significantly reduced after three months treatment . Nevertheless, when omalizumab is withdrawn after few months of therapy, the serum IgE levels return to pretreatment values as well as the number of IgE receptors on the basophils surface. This structural “involution” reflects the trend of the symptoms related to the asthmatic disease, leading patients to increase the dosage of standard therapy [34–44].
Nopp et al. investigated the long-term efficacy of 6-year-therapy with omalizumab in 18 patients with severe IgE-mediated asthma 1 year  and 3 years  after the withdrawal of omalizumab. In both cases the Authors documented the stabilization of the asthma-related symptoms, similar to that observed during the treatment period with omalizumab, as well as the downregulation of basophil allergen sensitivity.
The treatment with omalizumab should be potentiated by specific immunotherapy, which is active by using other immunologic mechanisms .
Recently, two studies investigated also the potential effects of omalizumab on airway remodeling. Hoshino et al.  evaluated the effects of omalizumab on airway wall thickening using Computed Tomography (CT). Thirty patients with severe persistent asthma were randomized to conventional therapy with (n = 14) or without omalizumab (n = 16) for 16 weeks; the airway dimensions were assessed by a validated CT technique. This study showed that 16 weeks of treatment with omalizumab reduced airway wall thickness. The change in wall thickness was associated with a marked reduction in sputum eosinophils, and improvement in pulmonary function and quality of life .
Riccio et al.  investigated the effect of long–term anti- IgE on the thickening of the reticular basement membrane (RBM) and eosinophil infiltration in bronchial biopsies from 11 patients with severe persistent allergic asthma before and after (12 months) treatment with omalizumab. The study showed that a substantial proportion of severe asthmatics reduced the original bronchial RBM thickness and eosinophil infiltration after one-year treatment with anti-IgE .
Omalizumab in allergic asthma
In several clinical controlled trials omalizumab resulted to be able to reduce asthma-related symptoms, to decrease corticosteroid use and to improve quality of life of asthmatic patients [28–44, 48–51] and some of these studies show the benefits of anti-IgE as add-on therapy in patients with severe persistent asthma who are inadequately controlled by anti- asthma pharmacological therapy (Additional file 1).
The anti-IgE approach to asthma treatment has several advantages, including concomitant treatment of other IgE-mediated diseases and a favorable side-effect profile regardless of the type of allergic sensitisation [28–34, 41–44, 48]. Omalizumab was shown not only to inhibit mast cell and basophil responses but also to have inhibiting effect on the inflammatory cells, such as eosinophils, T lymphocytes and B lymphocytes which are fundamental to the chronic inflammatory response in allergic diseases such as asthma. This background places anti-IgE therapy firmly in the domain of an anti-inflammatory treatment for chronic allergic disease, with effect on multiple cell types.
Omalizumab in severe asthma
Severe or refractory asthma remains a frustrating disease for both patients and the clinicians treating them. Severe asthma has been defined as persisting symptoms due to asthma despite high-dose inhaled steroids (1,000 mcg beclometasone dipropionate or equivalent) plus long-acting beta- 2 agonists, with the requirement for either maintenance systemic steroids or at least two rescue courses of steroids over 12 months and despite trials of add-ons such as leukotriene-receptor antagonist or theophylline.
The Global Initiative for Asthma (GINA)  guidelines for patients with severe persistent asthma (step 5 therapy) recommend the use of high-dose inhaled corticosteroids plus a long-acting beta- 2 agonist (LABA), and, if required, one more additional controller. Currently several studies showed benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled, despite best available therapy.
The INNOVATE (INvestigatioN of Omalizumab in seVere Asthma TrEatment) study was specifically designed to evaluate the efficacy and safety of add-on therapy with omalizumab in this difficult asthma population .
In the INNOVATE trial were enrolled patients aged 12-75 years with severe persistent allergic asthma (GINA step 3 or 4 clinical features despite step 4 therapy). The primary efficacy variable was the rate of clinically significant asthma exacerbations (defined as a worsening of asthma symptoms requiring treatment with systemic corticosteroids). A total of 419 patients were included in the efficacy analyses (omalizumab, n = 209; placebo, n = 210). The rate of clinically significant asthma exacerbations, after adjusting for an observed imbalance in asthma exacerbation history prior to randomization, was significantly reduced by 26.2% with omalizumab versus placebo (0.68 and 0.91, respectively; p = 0.042).
Compared with placebo, treatment with omalizumab significantly reduced the rate of severe asthma exacerbations (0.24 vs 0.48, p = 0.002) and the rate of total emergency visits for asthma (0.24 vs 0.43, p = 0.038). Significantly greater improvements were achieved with omalizumab compared with placebo in Asthma Quality of Life Questionnaire (AQLQ) scores (overall and individual domains), with a significantly greater proportion of patients receiving omalizumab achieving a clinically meaningful (> 0.5-point) improvement from baseline compared with placebo recipients (61% and 48%, respectively; p = 0.008).
Several “real life” studies confirmed the efficacy and tolerability of omalizumab in severe persistent allergic asthma patients.
One trial was an observational study performed in France . The second one was a prospective post-marketing surveillance trial that evaluated the efficacy and tolerability of omalizumab in real-life in Germany , and the third study was a prospective multicenter real-life study conducted in Belgium, the PERSIST study , the fourth was a small questionnaire-based observational study in 65 patients in the UK, who had continued with omalizumab therapy beyond 16 weeks, conducted by Niven et al. .
In the first study, the authors evaluated 154 patients. The analysis performed during the treatment period and compared to the previous year, showed that patients with a follow up of at least 5 months experienced 62% fewer exacerbations requiring oral corticosteroids, 65% fewer emergency department visits and 29% fewer hospitalisations per year. Korn and co-workers  reported the results of the observation of 280 patients followed up for 6 months. After 6 months of specific anti-IgE therapy, omalizumab was demonstrated to reduce the daily (−76%) and nocturnal symptoms (−84%), exacerbations (−82%), unscheduled medical assistance (−81%), hospitalisations (−78%) and increase quality of life (Mini-AQLQ: score increase from 2.9 to 4.5). Overall, efficacy of omalizumab was rated as excellent or good by the majority of physicians (82%) and patients (86%).
In the PERSIST Study Brusselle and co-workers  evaluated the 15- and 52-week effectiveness of add-on omalizumab treatment in 158 enrolled subjects. After 16 weeks of therapy, a good/excellent global evaluation of treatment effectiveness (GETE) was achieved by > 82% (p < 0.001), the total AQLQ scores improved in > 82% by > 0.5 points (p < 0.001) and > 91% of the subjects were exacerbation-free. At 52 weeks, the same results were achieved by > 72% (p < 0.001), > 84% (p < 0.001) and > 65% (p < 0.001), respectively. In addition, a significant reduction in healthcare utilization compared the year prior to treatment was observed.
Niven et al.  found that out of 33 patients taking oral corticosteroid at baseline, 18 (54.5%) had reduced their oral corticosteroid and 8 (24.2%) had stopped oral corticosteroid altogether. The mean relative reduction in oral corticosteroid dose from baseline was 49% (22.6–11.6 mg, prednisolone equivalent).
All these studies showed that anti-IgE treatment has a reassuring safety profile. It is tolerated, and its overall adverse event profile is similar to that of placebo (Additional file 2).
Safety and tolerability
In a review Corren and co-workers  evaluated the safety of omalizumab in a pooled analysis of data from 15 randomized multicentric studies involving more than 7,500 patients (adults, adolescents and children). All patients suffered from severe persistent allergic asthma and the majority of them received omalizumab for almost 24 weeks at the dose of 150-300 mg every four weeks or 225, 300 or 375 mg every two weeks. In all studies the number of adverse events (AEs) was similar between groups and the majority of AEs were mild or moderate. The most frequent AE observed in both groups was nasopharyngitis; no difference indicative of omalizumab specific tossicity was detected between groups. The only AE with > 2% difference between groups was sinusitis, observed in 10.1% of patients treated with omalizumab and in 12.2% in the placebo groups. The assessment of laboratory parameters did not show any significant effect of omalizumab on blood cells counts, renal and liver function; however, no data exist about patients with previous renal or hepatic impairment treated with omalizumab, thus caution should be used in administering the drug in these sets of patients. This review confirmed that add-on omalizumab is an effective and well tolerated treatment in patients with severe IgE-mediated asthma, and its cost-effectiveness is similar to other chronic disease biologics. Furthermore, the same authors highlight that, despite its cost, omalizumab used as an add-on therapy in this setting of patients improves quality-adjusted survival (QALYs) at an increase in direct medical costs, and that this value is directly related to the duration of the therapy.
Several other studies have been recently published. In the trial of Busse et al.  research has underscored the effects of exposure and sensitization to allergens on the severity of asthma in children and when added to a regimen of guidelines-based therapy for inner-city children, adolescents, and young adults, omalizumab further improved asthma control, nearly eliminated seasonal peaks in exacerbations, and reduced the need for other medications to control asthma.
In the study of Braunstahl et al.  by physician’s GETE, 69.9% of patients were responders to omalizumab after 16 weeks. The proportion of patients with no clinically significant exacerbations increased from 6.8% during the 12 month pre-treatment period to 54.1% and 67.3% at months 12 and 24, respectively. Symptoms and rescue medication use at month 24 were reduced by > 50% from baseline. Maintenance oral corticosteroids use was lower at month 24 (14.2%) compared with month 12 (16.1%) and baseline (28.6%). Overall, the results from eXpeRience registry indicate that omalizumab was associated with improvements in outcomes in patients with uncontrolled persistent allergic asthma and that these improvements were consistent with the results of clinical trials. However, omalizumab is effective in treating severe asthma also in patients with severe cardiovascular complications .
Omalizumab in other respiratory and non-respiratory diseases
The efficacy of omalizumab was also observed in patients with severe occupational asthma, regardless of whether the causative agent was high molecular weight (HMW) or low molecular weight (LMW) . This is particularly relevant for patients who are unable to avoid allergen exposure in their place of work.
Results of several large randomized trials have established omalizumab as an effective and well tolerated treatment for use as add-on therapy in patients with severe persistent allergic asthma. Several trials have demonstrated that this therapy is well tolerated and significantly improves symptoms and disease control, reducing asthma exacerbations and improving quality of life of asthma patients.
- European Respiratory Society (ERS)/European Lung Foundation: European lung white book. The first comprehensive survey on respiratory health in Europe. Edited by: Loddenkemper R, Gibson GJ, Sibille Y. 2003, Sheffield: ERSJGoogle Scholar
- Masoli M, Fabian D, Holt S, Beasley R, Global Initiative for Asthma (GINA) Program: The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy. 2004, 59: 469-478. 10.1111/j.1398-9995.2004.00526.x.View ArticlePubMedGoogle Scholar
- Rabe KF, Adachi M, Lai CK, Soriano JB, Vermeire PA, Weiss KB, Weiss ST: Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J Allergy Clin Immunol. 2004, 114: 40-47. 10.1016/j.jaci.2004.04.042.View ArticlePubMedGoogle Scholar
- De Marco R, Gappa V, Accordini S, Rava M, Antonicelli L, Bortolami O, Braggion M, Bugiani M, Casali L, Cazzoletti L, Cerveri I, Fois AG, Girardi P, Locatelli F, Marcon A, Marinoni A, Panico MG, Pirina P, Villani S, Zanolin ME, Verlato G, GEIRD Study Group: Trends in the prevalence of asthma and allergic rhinitis in Italy between 1991 and 2010. Eur Respir J. 2012, 39 (4): 883-892. 10.1183/09031936.00061611.View ArticlePubMedGoogle Scholar
- D’Amato G, Cecchi L, D’Amato M, Liccardi G: Urban air pollution and climate change as environmental risk factors of respiratory allergy: an update. J Invest Allergol Clin Immunol. 2010, 20: 95-102.Google Scholar
- Wenzel SE: Asthma: defining of the persistent adult phenotypes. Lancet. 2006, 368 (9537): 804-813. 10.1016/S0140-6736(06)69290-8.View ArticlePubMedGoogle Scholar
- The ENFUMOSA: cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma: European Network for Understanding Mechanisms of Severe Asthma. Eur Respir J. 2003, 22: 470-477. 10.1183/09031936.03.00261903.View ArticleGoogle Scholar
- Moore WC, Bleecker ER, Curran-Everett D, Erzurum SC, Ameredes BT, Bacharier L, Calhoun WJ, Castro M, Chung KF, Clark MP, Dweik RA, Fitzpatrick AM, Gaston B, Hew M, Hussain I, Jarjour NN, Israel E, Levy BD, Murphy JR, Peters SP, Teague WG, Meyers DA, Busse WW, Wenzel SE, National Heart, Lung, Blood Institute's Severe Asthma Research Program: Characterization of the severe asthma phenotype by the National Heart. Lung and Blood Institute’s Severe Asthma Research Program. J Allergy Clin Immunol. 2007, 119: 405-413. 10.1016/j.jaci.2006.11.639.PubMed CentralView ArticlePubMedGoogle Scholar
- Busse WW, Banks-Schlegel S, Wenzel SE: Pathophysiology of severe asthma. J Allergy Clin Immunol. 2000, 106: 1033-1042. 10.1067/mai.2000.111307.View ArticlePubMedGoogle Scholar
- Novak N, Bieber T: Allergic and nonallergic forms of atopic diseases. J Allergy Clin Immunol. 2003, 112: 252-262. 10.1067/mai.2003.1595.View ArticlePubMedGoogle Scholar
- Hollowaj JA, Holgate ST, Semper AE: Expression of the high-affinity IgE receptor on peripheral blood dendritic cells: differential binding of IgE in atopic asthma. J Allergy Clin Immunol. 2001, 107: 1009-1018. 10.1067/mai.2001.115039.View ArticleGoogle Scholar
- Pelaia G, Vatrella A, Maselli R: The potential of biologics for treatment of asthma. Nat Rev Drug Discov. 2012, 11 (12): 958-972. 10.1038/nrd3792.View ArticlePubMedGoogle Scholar
- National Institutes of Health/National Heart Lung and Blood Institute (NHLBI): Global Initiate for Asthma. 2011, Bethesda, MD: Global Strategy for Asthma Management and Prevention NHLBI/WHO Workshop ReportGoogle Scholar
- Van Ganse E, Laforest L, Pietri G, Boissel JP, Gormand F, Ben-Joseph R, Ernst P: Persistent asthma: disease control, resource utilisation and direct costs. Eur Respir J. 2002, 20: 260-270. 10.1183/09031936.02.02542001.View ArticlePubMedGoogle Scholar
- Boulet L-P, Chapman KR, Cote J, Côté J, Kalra S, Bhagat R, Swystun VA, Laviolette M, Cleland LD, Deschesnes F, Su JQ, DeVault A, Fick RB, Cockcroft DW: Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response. Am J Respir Crit Care Med. 1997, 155: 1835-1840. 10.1164/ajrccm.155.6.9196083.View ArticlePubMedGoogle Scholar
- Godard P, Chanez L, Siraudin L, Nicoloyannis N, Duru G: Costs of asthma are correlated with severity: a 1-yr prospective study. Eur Respir J. 2002, 19: 61-67. 10.1183/09031936.02.00232001.View ArticlePubMedGoogle Scholar
- Fahy JV, Fleming HE, Wong HH, Liu JT, Su JQ, Reimann J, Fick RB, Boushey HA: The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects. Am J Respir Crit Care Med. 1997, 155: 1828-1834. 10.1164/ajrccm.155.6.9196082.View ArticlePubMedGoogle Scholar
- Fahy JV: The anti-IgE treatment strategy for asthma. New and Exploratory Therapeutic Agents for Asthma: Lung Biology in Health and Disease. Edited by: Yeadon M, Diamant Z. 2000, New York: Marcel Dekker, 329-342.Google Scholar
- Chang TW: The pharmacological basis of anti-IgE therapy. Nat Biotechnol. 2000, 18: 157-162. 10.1038/72601.View ArticlePubMedGoogle Scholar
- D’Amato G, Oldani V, Donner C: Treating atopic asthma with the anti-IgE monoclonal antibody. Monaldi Arch Chest Dis. 2002, 57 (2): 117-119.PubMedGoogle Scholar
- D’Amato G: Therapy of allergic bronchial asthma with anti-IgE monoclonal antibody. Expert Opin Biol Ther. 2003, 3: 371-376. 10.1517/147125220.127.116.111.View ArticlePubMedGoogle Scholar
- D’Amato G, Bucchioni E, Oldani V, Canonica W: Treating Moderate-to-Severe Allergic Asthma with a Recombinant Humanized Anti-IgE Monoclonal Antibody (Omalizumab). Treat Respir Med. 2006, 5 (6): 393-398. 10.2165/00151829-200605060-00004.View ArticlePubMedGoogle Scholar
- Takaku Y, Soma T, Nishihara F, Nakagome K, Kobayashi T, Hagiwara K, Kanazawa M, Nagata M: Omalizumab attenuates airway inflammation and interleukin-5 production by mononuclear cells in patients with severe allergic asthma. Int Arch Allergy Immunol. 2013, 161 (Suppl 2): 107-117.View ArticlePubMedGoogle Scholar
- Kuehr J, Brauburger J, Zielen S, Schauer U, Kamin W, Von Berg A, Leupold W, Bergmann KC, Rolinck-Werninghaus C, Gräve M, Hultsch T, Wahn U: Efficacy of combination treatment with anti-IgE plus specific immunotherapy in polysensitized children and adolescents with seasonal allergic rhinitis. J Allergy Clin Immunol. 2002, 109: 274-280. 10.1067/mai.2002.121949.View ArticlePubMedGoogle Scholar
- Holgate S, Bousquet J, Wenzel S, Fox H, Liu J, Castellsague J: Efficacy of omalizumab, an anti-immunoglobulin E antibody, in patients with allergic asthma at high risk of serious asthma-related morbidity and mortality. Curr Med Res Opin. 2001, 17: 233-240.View ArticlePubMedGoogle Scholar
- D’Amato G: Role of anti-IgE monoclonal antibody (omalizumab) in the treatment of allergic respiratory diseases. Eur J Pharmacol. 2006, 533 (1–3): 302-307.View ArticlePubMedGoogle Scholar
- Soler M, Matz J, Townley R, Buhl R, O’Brien J, Fox H, Thirlwell J, Gupta N, Della Cioppa G: The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics. Eur Respir J. 2001, 18: 254-261. 10.1183/09031936.01.00092101.View ArticlePubMedGoogle Scholar
- Busse W, Coren J, Lanier BQ, McAlary M, Fowler-Taylor A, Della Cioppa G, van As A, Gupta N: Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma. J Allergy Clin Immunol. 2001, 108: 184-190. 10.1067/mai.2001.117880.View ArticlePubMedGoogle Scholar
- Babu KS, Polosa R, Morjaria JB: Anti-IgE-emerging opportunities for Omalizumab. Expert Opin Biol Ther. 2013, 13 (5): 765-777. 10.1517/14712598.2013.782391.View ArticlePubMedGoogle Scholar
- Milgrom H, Berger W, Nayak A, Gupta N, Pollard S, McAlary M, Taylor AF, Rohane P: Treatment of childhood asthma with anti-immunoglobulin E antibody (omalizumab). Pediatrics. 2001, 108 (2): 36-45. 10.1542/peds.108.2.e36.View ArticleGoogle Scholar
- Buhl R, Soler M, Matz J, Townley R, O’Brien J, Noga O, Champain K, Fox H, Thirlwell J, Della Cioppa G: Omalizumab provides long-term control in patients with moderate-to-severe allergic asthma. Eur Respir J. 2002, 20: 73-78. 10.1183/09031936.02.00278102.View ArticlePubMedGoogle Scholar
- Buhl R, Hanf G, Soler M, Bensch G, Wolfe J, Everhard F, Champain K, Fox H, Thirlwell J: The anti-IgE antibody omalizumab improves asthma-related quality of life in patients with allergic asthma. Eur Respir J. 2002, 20: 1088-1094. 10.1183/09031936.02.00016502.View ArticlePubMedGoogle Scholar
- Ayres JG, Higgins B, Chilvers ER, Ayre G, Blogg M, Fox H: Efficacy and tolerability of anti-immunoglobulin E therapy with omalizumab in patients with poorly controlled (moderate-to-severe) allergic asthma. Allergy. 2004, 59: 701-708. 10.1111/j.1398-9995.2004.00533.x.View ArticlePubMedGoogle Scholar
- Holgate S, Casale T, Wenzel S, Bousquet J, Deniz Y, Reisner C: The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation. J Allergy Clin Immunol. 2005, 115: 459-465. 10.1016/j.jaci.2004.11.053.View ArticlePubMedGoogle Scholar
- Saini SS, MacGlashan DW, Sternisky SA, Togias A, Adelman DC, Lichtenstein LM, Bochner BS: Down-regulation of human basophil IgE and FcϵRIα surface densities and mediator release by anti-IgE-infusion reversible in vitro and in vivo. J Immunol. 1999, 162: 5624-5630.PubMedGoogle Scholar
- Nopp A, Johansson SGO, Ankerst J, Palmqvist M, Öman H: CD-sens and clinical changes during withdrawal of Xolair after 6 years of treatment. Allergy. 2007, 62: 1175-1181. 10.1111/j.1398-9995.2007.01476.x.View ArticlePubMedGoogle Scholar
- Nopp A, Johansson SGO, Adédoyin J, Ankerst J, Palmqvist M, Öman H: After 6 years with Xolair; a 3-year withdrawal follow-up. Allergy. 2009, 65: 56-60.View ArticlePubMedGoogle Scholar
- Adelroth E, Rak S, Haahtela T, Aasand G, Rosenhall L, Zetterstrom O, Byrne A, Champain K, Thirlwell J, Cioppa GD, Sandström T: Recombinant humanized mAb E25, an anti-IgE mAb, in birch pollen-induced seasonal allergic rhinitis. J Allergy Clin Immunol. 2000, 106 (2): 253-259. 10.1067/mai.2000.108310.View ArticlePubMedGoogle Scholar
- Plewako H, Arvidsson M, Petruson K, Oancea I, Holmberg K, Adelroth E, Gustafsson H, Sandström T, Rak S: The effect of omalizumab on nasal allergic inflammation. J Allergy Clin Immunol. 2002, 110: 68-71. 10.1067/mai.2002.125488.View ArticlePubMedGoogle Scholar
- Kopp MV, Brauburger J, Riedinger F, Beischer D, Ihorst G, Kamin W, Zielen S, Bez , Friedrichs F, Von Berg A, Gerhold K, Hamelmann E, Hultsch , Kuehr J: The effect of anti-IgE treatment on in vitro leukotriene release in children with seasonal allergic rhinitis. J Allergy Clin Immunol. 2002, 110: 728-735. 10.1067/mai.2002.128804.View ArticlePubMedGoogle Scholar
- Vignola AM, Humbert M, Bousquet J, Boulet LP, Hedgecock S, Blogg M, Fox H, Surrey K: Efficacy and tolerability of anti-immunoglobulin E therapy with omalizumab in patients with concomitant allergic asthma and persistent allergic rhinitis:SOLAR. Allergy. 2004, 59: 709-717. 10.1111/j.1398-9995.2004.00550.x.View ArticlePubMedGoogle Scholar
- Wenzel S: Severe asthma in adults. Am J Respir Crit Care Med. 2005, 172: 149-160. 10.1164/rccm.200409-1181PP.View ArticlePubMedGoogle Scholar
- Humbert M, Beaskey R, Ayres J, Slavin R, Hébert J, Bousquet J, Beeh KM, Ramos S, Canonica GW, Hedgecock S, Fox H, Blogg M, Surrey K: Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE. Allergy. 2005, 60: 309-316. 10.1111/j.1398-9995.2004.00772.x.View ArticlePubMedGoogle Scholar
- Molimard M, de Blay F, Didier A, Le Gros V: Effectiveness of omalizumab (Xolair) in the first patients treated in real-life practice in France. Respir Med. 2008, 102 (1): 71-76. 10.1016/j.rmed.2007.08.006.View ArticlePubMedGoogle Scholar
- Kopp MV, Hamelmann E, Bendiks M, Zielen S, Kamin W, Bergmann KC, Klein C, Wahn U, DUAL study group: Transient impact of omalizumab in pollen allergic patients undergoing specific immunotherapy. Pediatr Allergy Immunol. 2013, 24 (5): 427-433. 10.1111/pai.12098.View ArticlePubMedGoogle Scholar
- Hoshino M, Ohtawa J: Effects of adding omalizumab, an anti-immunoglobulin E antibody on airway wall thickening in asthma. Respiration. 2012, 83: 520-528. 10.1159/000334701.View ArticlePubMedGoogle Scholar
- Riccio AM, Dal Negro RW, Micheletto C, De Ferrari L, Folli C, Chiappori A, Canonica GW: Omalizumab modulates bronchial reticular basement membrane thickness and eosinophil infiltration in severe persistent allergic asthma patient. Int J Immunopathol Pharmacol. 2012, 25 (2): 475-484.PubMedGoogle Scholar
- Korn S, Thielen A, Seyfried S, Taube C, Kornmann O, Buhl R: Omalizumab in patients with severe persistent allergic asthma in a real-life setting in Germany. Respir Med. 2009, 103 (11): 1725-1731. 10.1016/j.rmed.2009.05.002.View ArticlePubMedGoogle Scholar
- Brusselle G, Michils A, Louis R, Dupont L, Van de Maele B, Delobbe A, Pilette C, Lee CS, Gurdain S, Vancayzeele S, Lecomte P, Hermans C, MacDonald K, Song M, Abraham I: Real-life” effectiveness of omalizumab in patients with severe persistent allergic asthma: The PERSIST study. Respir Med. 2009, 103 (11): 1633-1642. 10.1016/j.rmed.2009.06.014.View ArticlePubMedGoogle Scholar
- Niven R: A UK survey of oral corticosteroid use in patients treated with omalizumab. Thorax. 2007, 62 (Suppl3): A98-Google Scholar
- Corren J, Casale TB, Lanier B, Buhl R, Holgate S, Jimenez P: Safety and tolerability of omalizumab. Clin Exp Allergy. 2009, 39: 788-797. 10.1111/j.1365-2222.2009.03214.x.View ArticlePubMedGoogle Scholar
- Busse WW, Morgan WJ, Gergen PJ, Mitchell HE, Gern JE, Liu AH, Gruchalla RS, Kattan M, Teach SJ, Pongracic JA, Chmiel JF, Steinbach SF, Calatroni A, Togias A, Thompson KM, Szefler SJ, Sorkness CA: Randomized trial of Omalizumab (Anti-IgE) for asthma in inner-City children. N Engl J Med. 2011, 364: 1005-1015. 10.1056/NEJMoa1009705.PubMed CentralView ArticlePubMedGoogle Scholar
- Braunstahl GJ, Chen CW, Maykut R, Georgiou P, Peachey G, Bruce J: The eXpeRience registry: the “real-world” effectiveness of omalizumab in allergic asthma. Respir Med. 2013, 107 (8): 1141-1151. 10.1016/j.rmed.2013.04.017.View ArticlePubMedGoogle Scholar
- Yalcin AD, Cilli A, Bisgin A, Strauss LG, Herth F: Omalizumab is effective in treating severe asthma in patients with severe cardiovascular complications and its effects on sCD200, d-dimer, CXCL8, 25-hydroxyvitamin D and IL-1bβ levels. Expert Opin Biol Ther. 2013, 13 (9): 1335-1341. 10.1517/14712598.2013.819338.View ArticlePubMedGoogle Scholar
- Lommatzsch M, Korn S, Buhl R, Virchow JC: Against all odds: anti-IgE for intrinsic asthma?. Thorax. 2013, doi:10.1136/thoraxjnl-2013-203738Google Scholar
- Maselli DJ, Singh H, Diaz J, Peters JI: Efficacy of omalizumab in asthmatic patients with IgE levels above 700 IU/mL. Ann Allergy Asthma Immunol. 2013, 110 (6): 457-461. 10.1016/j.anai.2013.04.011.View ArticlePubMedGoogle Scholar
- Naclerio RM, Baroody FM, Pinto JM: Should clinicians use omalizumab for the treatment of nasal polyps?. J Allergy Clin Immunol. 2013, 132 (1): 247-View ArticlePubMedGoogle Scholar
- Tajiri T, Matsumoto H, Hiraumi H, Ikeda H, Morita K, Izuhara K, Ono J, Ohta S, Ito I, Oguma T, Nakaji H, Inoue H, Iwata T, Nagasaki T, Kanemitsu Y, Ito J, Niimi A, Mishima M: Efficacy of omalizumab in eosinophilic chronic rhinosinusitis patients with asthma. Ann Allergy Asthma Immunol. 2013, 110 (5): 387-388. 10.1016/j.anai.2013.01.024.View ArticlePubMedGoogle Scholar
- Vashisht P, Casale T: Omalizumab for the treatment of allergic rhinitis. Expert Opin Biol Ther. 2013, 13 (6): 933-945. 10.1517/14712598.2013.795943.View ArticlePubMedGoogle Scholar
- Domingo C, Pomares X, Angril N, Rudi N, Amengual MJ, Mirapeix RM: Effectiveness of omalizumab in non allergic severe asthma. J Biol Regul Homeost Agents. 2013, 27 (1): 45-53.PubMedGoogle Scholar
- Lavaud F, Bonniaud P, Dalphin JC, Leroyer C, Muller D, Tannous R, Mangiapan G, De Blay F: Usefulness of omalizumab in ten patients with severe occupational asthma. Allergy. 2013, 68 (6): 813-815. 10.1111/all.12149.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.