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  1. Original research article

    Efficacy of recombinant human soluble thrombomodulin for the treatment of acute exacerbation of idiopathic pulmonary fibrosis: a single arm, non-randomized prospective clinical trial

    Coagulation abnormalities are involved in the pathogenesis of acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF). The administration of recombinant human soluble thrombomodulin (rhTM), which has bot...

    Sho Hayakawa, Yasuo Matsuzawa, Tamako Irie, Hagino Rikitake, Noriaki Okada and Yasuo Suzuki

    Multidisciplinary Respiratory Medicine 2016 11:38

    Published on: 7 November 2016

  2. Letter to the Editor

    Cost comparison of asthma treatments in 12-week study: caution about matching and short observational follow-up

    In the absence of randomisation, observational studies must take extra care to create treatment groups that are comparable in terms of key characteristics. Various matching methods exist which can create sound...

    David B. Price, Job F. M. van Boven, Lisa M. Law, Alessandra Cifra and R. Brett McQueen

    Multidisciplinary Respiratory Medicine 2016 11:39

    Published on: 2 November 2016

  3. Review

    Asthma-related deaths

    Despite major advances in the treatment of asthma and the development of several asthma guidelines, people still die of asthma currently. According to WHO estimates, approximately 250,000 people die prematurel...

    Gennaro D’Amato, Carolina Vitale, Antonio Molino, Anna Stanziola, Alessandro Sanduzzi, Alessandro Vatrella, Mauro Mormile, Maurizia Lanza, Giovanna Calabrese, Leonardo Antonicelli and Maria D’Amato

    Multidisciplinary Respiratory Medicine 2016 11:37

    Published on: 12 October 2016

  4. Original research article

    The effect of positive airway pressure therapy on neurocognitive functions, depression and anxiety in obesity hypoventilation syndrome

    The aim of this study is to evaluate the presence of neurocognitive dysfunctions, depression and anxiety and the effect of positive airway pressure (PAP) therapy on these alterations in Obesity Hypoventilation...

    Serap Argun Baris, Dilek Tuncel, Cigdem Ozerdem, Huseyin Kutlu, Tugba Onyilmaz, Ilknur Basyigit, Hasim Boyaci and Fusun Yildiz

    Multidisciplinary Respiratory Medicine 2016 11:35

    Published on: 11 October 2016

  5. Original research article

    Preliminary study on the assessment of visceral adipose tissue using dual-energy x-ray absorptiometry in chronic obstructive pulmonary disease

    Visceral adipose tissue (VAT) was shown to be increased in patients with chronic obstructive pulmonary disease (COPD) compared to control subjects with comparable body mass index (BMI). Our aim was to determin...

    Francesca De Blasio, Erica P. A. Rutten, Emiel F. M. Wouters, Luca Scalfi, Francesco De Blasio, Marco A. Akkermans, Martijn A. Spruit and Frits M. E. Franssen

    Multidisciplinary Respiratory Medicine 2016 11:33

    Published on: 4 October 2016

  6. Original research article

    Cough: impact, beliefs, and expectations from a national survey

    Cough is one of the most common discomforts affecting general population, which can disrupt subjects’ quality of life due to its physical, social, and psychological effects. Aim of the study was to investigate...

    Roberto W. Dal Negro, Massimiliano Mazzolini, Paola Turco and Alessandro Zanasi

    Multidisciplinary Respiratory Medicine 2016 11:34

    Published on: 27 September 2016

  7. Original research article

    Cultural and linguistic validation of the NHQ-2 Questionnaire: a specific instrument for assessing patient’s usability of inhalation devices

    An increasing number of inhalation devices are presently available in the market. They are differently characterized in terms of their handling and usability, both factors which may affect the outcomes of resp...

    Roberto W. Dal Negro and Massimiliano Povero

    Multidisciplinary Respiratory Medicine 2016 11:32

    Published on: 23 August 2016

  8. Review

    Obesity: systemic and pulmonary complications, biochemical abnormalities, and impairment of lung function

    Obesity is currently one of the major epidemics of this millennium and affects individuals throughout the world. It causes multiple systemic complications, some of which result in severe impairment of organs a...

    Thiago Thomaz Mafort, Rogério Rufino, Cláudia Henrique Costa and Agnaldo José Lopes

    Multidisciplinary Respiratory Medicine 2016 11:28

    Published on: 12 July 2016

  9. Original research article

    Most Italians attending a congress on health of elderly people do not know and do not recognize respiratory diseases

    The present study reports the results of a survey jointly carried out by three Italian respiratory scientific associations (AIMAR, AIPO, SIMeR) together with an important Federation of elderly patients (FederA...

    Nicola Ciancio, Claudio M. Sanguinetti, Franco Falcone, Claudio Taranto, Roberto Fasani, Fernando De Benedetto, Onofrio Resta, Fausto De Michele, Roberto Messina, Andrea Rossi, Stefano Nardini and Giuseppe Di Maria

    Multidisciplinary Respiratory Medicine 2016 11:26

    Published on: 5 July 2016

  10. Original research article

    High bacterial load of indoor air in hospital wards: the case of University of Gondar teaching hospital, Northwest Ethiopia

    The air inhaled by people is abundantly populated with microorganisms which also are called bioaerosols. Bioaerosols is a colloidal suspension, formed by liquid droplets and particles of solid matter in the ai...

    Zemichael Gizaw, Mulat Gebrehiwot and Chalachew Yenew

    Multidisciplinary Respiratory Medicine 2016 11:24

    Published on: 5 July 2016

  11. Case report

    Sarcoidosis with prevalent and severe joint localization: a case report

    Sarcoidosis is a systemic granulomatous disease of unknown origin, characterized by the formation of granulomas without central necrosis. Each organ and tissue can be affected by the disease, but in most cases...

    Livio G. Moccia, Sabrina Castaldo, Emanuela Sirignano, Maddalena Napolitano, Enrica Barra and Alessandro Sanduzzi

    Multidisciplinary Respiratory Medicine 2016 11:27

    Published on: 29 June 2016

  12. Original research article

    Evaluation of the rapid immunochromatographic ODK0501 assay for Streptococcus pneumoniae antigen detection with nasopharyngeal swabs: preliminary report

    Early identification and control of pathogenic bacteria are important in the treatment of pneumonia. Currently, two rapid antigen detection kits for pneumococcal pneumonia are available: one uses urine samples...

    Shoji Suzuki, Naoki Nishimura, Torahiko Jinta, Yasuhiko Yamano, Genta Ishikawa, Yutaka Tomishima, Noboru Uchiyama and Naohiko Chohnabayashi

    Multidisciplinary Respiratory Medicine 2016 11:25

    Published on: 20 June 2016

  13. Original research article

    Prospective study of the efficacy of antibiotics versus antitussive drugs for the management of URTI-related acute cough in children

    Acute cough is one of the most frequent symptoms prompting a visit to a health care provider, usually following a viral upper respiratory tract infection (URTI). The disproportionate use of antibiotics in chil...

    Alessandro Zanasi, Luigi Lanata, Federico Saibene, Giovanni Fontana, Peter V. Dicpinigaitis, Valentina Venier and Francesco De Blasio

    Multidisciplinary Respiratory Medicine 2016 11:29

    Published on: 13 June 2016

  14. Original research article

    Fluticasone furoate/Vilanterol 92/22 μg once-a-day vs Beclomethasone dipropionate/ Formoterol 100/6 μg b.i.d.: a 12-week cost analysis in mild-to-moderate asthma

    Asthma is a disease with high cost for the National Health Service. Two of the most recent LABA/ICS combinations for persistent bronchial asthma are Beclomethasone dipropionate/Formoterol (B/F) delivered via t...

    Roberto W. Dal Negro, Chiara Distante, Luca Bonadiman, Paola Turco and Sergio Iannazzo

    Multidisciplinary Respiratory Medicine 2016 11:20

    Published on: 6 June 2016

  15. Original research article

    Acid–base balance, serum electrolytes and need for non-invasive ventilation in patients with hypercapnic acute exacerbation of chronic obstructive pulmonary disease admitted to an internal medicine ward

    Hypoventilation produces or worsens respiratory acidosis in patients with hypercapnia due to acute exacerbations of chronic obstructive pulmonary disease (AECOPD). In these patients acid–base and hydroelectrol...

    Alfonso Schiavo, Maurizio Renis, Mario Polverino, Arcangelo Iannuzzi and Francesca Polverino

    Multidisciplinary Respiratory Medicine 2016 11:23

    Published on: 25 May 2016

  16. Original research article

    Effectiveness, safety and tolerability of a complex homeopathic medicinal product in the prevention of recurrent acute upper respiratory tract infections in children: a multicenter, open, comparative, randomized, controlled clinical trial

    The present study was initiated to investigate the effectiveness, safety and tolerability of complex homeopathic CalSuli-4-02 tablets on prevention of recurrent acute upper respiratory tract infections (URTIs)...

    Miek C. Jong, Stephen L. Buskin, Lydia Ilyenko, Irina Kholodova, Julia Burkart, Stephan Weber, Thomas Keller and Petra Klement

    Multidisciplinary Respiratory Medicine 2016 11:19

    Published on: 16 May 2016

  17. Original research article

    Prevalence of pulmonary tuberculosis in young adult patients with Type 1 diabetes mellitus in India

    There is limited information on prevalence of pulmonary tuberculosis (PTB) in patients with type-1-diabetes. We assessed the prevalence of PTB in patients with type-1-diabetes attending the outpatient-clinic i...

    Abilash Nair, Randeep Guleria, Devasenathipathy Kandasamy, Raju Sharma, Nikhil Tandon, Urvashi B. Singh and Ravinder Goswami

    Multidisciplinary Respiratory Medicine 2016 11:22

    Published on: 10 May 2016

  18. Review

    Mometasone furoate nasal spray: a systematic review

    The inflammatory diseases of the nose, rhino-pharynx and paranasal sinuses (allergic and non allergic rhinitis, NARES; rhinosinusitis with/without nasal polyposis, adenoidal hypertrophy with/without middle ear...

    Desiderio Passali, Maria Carla Spinosi, Anna Crisanti and Luisa Maria Bellussi

    Multidisciplinary Respiratory Medicine 2016 11:18

    Published on: 2 May 2016

  19. Original research article

    Placement of self-expandable bifurcated metallic stents without use of fluoroscopic and guidewire guidance to palliate central airway lesions

    Self-expandable metallic stents (SEMS) can be used to treat malignant obstructions and fistulas of the central airways. SEMS can be placed using different methods. Recently, a rigid bronchoscope has been used ...

    Cengiz Özdemir, Sinem Nedime Sökücü, Levent Karasulu, Seda Tural Önür and Levent Dalar

    Multidisciplinary Respiratory Medicine 2016 11:15

    Published on: 30 April 2016

  20. Case report

    Tracheobronchopathia Osteochondroplastica: a rare case report of a non-smoker and non-atopic patient, with a long history of wheezing since childhood

    Tracheobronchopathia Osteochondroplastica (TBPO) is an uncommon and benign condition characterized by osseous or metaplastic cartilaginous 1–3 mm nodules in the submucosa of the tracheo-bronchial tree. Posteri...

    Alessandro G. Fois, Antonella Arcadu, Luigi Santoru, Rocco Trisolini, Vincenzo Marras, Giorgio C. Ginesu, Sara Canu, Lorenzo Cordero, Gabriella Diana and Pietro Pirina

    Multidisciplinary Respiratory Medicine 2016 11:16

    Published on: 19 April 2016

  21. Original research article

    Increased expression of A Proliferation-inducing Ligand (APRIL) in lung leukocytes and alveolar epithelial cells in COPD patients with non small cell lung cancer: a possible link between COPD and lung cancer?

    Chronic Obstructive Pulmonary Disease (COPD) is characterized by an excessive activation of the adaptive immune system and, in particular, uncontrolled expansion of the B-cell pool. One of the key promoters of...

    Francesca Polverino, Maria Laucho-Contreras, Joselyn Rojas Quintero, Miguel Divo, Victor Pinto-Plata, Lynette Sholl, Juan P. de-Torres, Bartolome R. Celli and Caroline A. Owen

    Multidisciplinary Respiratory Medicine 2016 11:17

    Published on: 4 April 2016

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