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  1. Review

    Recent advances in capsule-based dry powder inhaler technology

    Pulmonary drug delivery is currently the focus of accelerated research and development because of the potential to produce maximum therapeutic benefit to patients by directly targeting drug to the site of path...

    Federico Lavorini, Massimo Pistolesi and Omar S. Usmani

    Multidisciplinary Respiratory Medicine 2017 12:11

    Published on: 22 May 2017

  2. Original research article

    Using PaCO2 values to grade obesity-hypoventilation syndrome severity: a retrospective study

    To date, an important aspect that has still not been clarified is the assessment of OHS severity. The purpose of this retrospective study was to evaluate whether grading OHS severity according to PaCO2 values may...

    Mario Francesco Damiani, Vito Antonio Falcone, Pierluigi Carratù, Cristina Scoditti, Elioda Bega, Silvano Dragonieri, Alfredo Scoditti and Onofrio Resta

    Multidisciplinary Respiratory Medicine 2017 12:14

    Published on: 18 May 2017

  3. Review

    The evidence on tiotropium bromide in asthma: from the rationale to the bedside

    Severe and poorly controlled asthma still accounts for a great portion of the patients affected. Disease control and future risk management have been identified by international guidelines as the main goals in...

    Dejan Radovanovic, Pierachille Santus, Francesco Blasi and Marco Mantero

    Multidisciplinary Respiratory Medicine 2017 12:12

    Published on: 4 May 2017

  4. Review

    Tele-medicine in respiratory diseases

    Information and Communication Technologies applied to health care and advances in sensor and data transmission technology allowed tele-medicine based programs of care also for patients with respiratory diseases.

    Nicolino Ambrosino, Dewi Nurul Makhabah and Yusup Subagio Sutanto

    Multidisciplinary Respiratory Medicine 2017 12:9

    Published on: 20 April 2017

  5. Original research article

    Longitudinal assessment of bleomycin-induced lung fibrosis by Micro-CT correlates with histological evaluation in mice

    The intratracheal instillation of bleomycin in mice induces early damage to alveolar epithelial cells and development of inflammation followed by fibrotic tissue changes and represents the most widely used mod...

    Francesca Ruscitti, Francesca Ravanetti, Jeroen Essers, Yanto Ridwan, Sasha Belenkov, Wim Vos, Francisca Ferreira, Alex KleinJan, Paula van Heijningen, Cedric Van Holsbeke, Antonio Cacchioli, Gino Villetti and Franco Fabio Stellari

    Multidisciplinary Respiratory Medicine 2017 12:8

    Published on: 10 April 2017

  6. Review

    A reappraisal of the mucoactive activity and clinical efficacy of bromhexine

    Since its introduction to the market in 1963, bromhexine, an over-the-counter drug, has been investigated for its activity in animal models and in humans with diverse respiratory conditions. Bromhexine is a de...

    Alessandro Zanasi, Massimiliano Mazzolini and Ahmad Kantar

    Multidisciplinary Respiratory Medicine 2017 12:7

    Published on: 20 March 2017

  7. Original research article

    Characteristics of an optimized patient information material for elderly patients with obstructive pulmonary diseases based on patients’ and experts’ assessment

    Life-long regular use of drugs is necessary in chronic diseases like asthma and COPD. There are several methods to improve adherence including patient information and education; however, their effectiveness on...

    Gábor Tomisa, Alpár Horváth, Brigitta Dombai and Lilla Tamási

    Multidisciplinary Respiratory Medicine 2017 12:6

    Published on: 14 March 2017

  8. Letter to the Editor

    Ventilator associated pneumonia or ventilator induced pneumonia

    Ventilator associated pneumonia currently in vogue seems to have some pitfalls as far as the nomenclature is concerned and thus it imparts an erroneous impression to the reader. As the driving force is in fact...

    Zahid Hussain Khan, Piero Ceriana and Claudio F. Donner

    Multidisciplinary Respiratory Medicine 2017 12:5

    Published on: 28 February 2017

  9. Letter to the Editor

    Once daily aerosolised tobramycin in adult patients with cystic fibrosis in the management of Pseudomonas aeruginosa chronic infection

    It is estimated that about 60–70% of Cystic Fibrosis patients develop Pseudomonas aeruginosa chronic infection, with progressive loss of lung function, as well as increased antibiotic resistance and mortality.

    Marco Mantero, Andrea Gramegna, Giovanna Pizzamiglio, Alice D’Adda, Paolo Tarsia and Francesco Blasi

    Multidisciplinary Respiratory Medicine 2017 12:2

    Published on: 7 February 2017

  10. Original research article

    Pulmonary arterial hypertension associated with interferon therapy: a population-based study

    Isolated cases of pulmonary arterial hypertension (PAH) with interferon α or β therapy have been reported, but no population-based estimates of the incidence of the disease after interferon exposure are availa...

    Ravikanth Papani, Alexander G. Duarte, Yu-li Lin, Yong-Fang Kuo and Gulshan Sharma

    Multidisciplinary Respiratory Medicine 2017 12:1

    Published on: 17 January 2017

  11. Original research article

    Bibliometric analysis of worldwide publications on multi-, extensively, and totally drug – resistant tuberculosis (2006–2015)

    The year 2015 marked the end of United Nations Millennium Development Goals which was aimed at halting and reversing worldwide tuberculosis (TB). The emergence of drug resistance is a major challenge for world...

    Waleed M. Sweileh, Adham S. AbuTaha, Ansam F. Sawalha, Suleiman Al-Khalil, Samah W. Al-Jabi and Sa’ed H. Zyoud

    Multidisciplinary Respiratory Medicine 2017 11:45

    Published on: 11 January 2017

  12. Original research article

    Cost of persistent asthma in Italy

    Asthma is a common disease of the airways with a significant burden for the society and for patients’ quality of life. The Social Impact of Respiratory Integrated Outcomes (SIRIO) study estimated a mean cost o...

    Roberto W. Dal Negro, Chiara Distante, Luca Bonadiman, Paola Turco and Sergio Iannazzo

    Multidisciplinary Respiratory Medicine 2016 11:44

    Published on: 16 December 2016

  13. Original research article

    DNA damage and repair capacity in lymphocyte of chronic obstructive pulmonary diseases patients during physical exercise with oxygen supplementation

    We hypothesized that the use of oxygen supplementation during aerobic exercise induces less DNA damage than exercise alone.

    Andréa Lúcia Gonçalves da Silva, Thaís Evelyn Karnopp, Augusto Ferreira Weber, Cassia da Luz Goulart, Paloma de Borba Scheneiders, Dannuey Machado Cardoso, Lisiane Lisboa Carvalho, Joel Henrique Ellwanger, Lia Gonçalves Possuelo and Andréia Rosane de Moura Valim

    Multidisciplinary Respiratory Medicine 2016 11:43

    Published on: 14 December 2016

  14. Original research article

    Personality and unachieved treatment goals related to poor adherence to asthma medication in a newly developed adherence questionnaire – a population-based study

    Health-care professionals have a responsibility to be attentive to patients’ adherence behavior but it could be difficult to identify poor adherence in the context of clinical practice. Assessment of personali...

    Malin Axelsson, Linda Ekerljung, Bo Lundbäck and Jan Lötvall

    Multidisciplinary Respiratory Medicine 2016 11:42

    Published on: 5 December 2016

  15. Original research article

    Hemothorax following lung transplantation: incidence, risk factors, and effect on morbidity and mortality

    Hemothorax after lung transplantation may result in increased post-operative morbidity and mortality. Risk factors for developing hemothorax and the outcomes of patients who develop hemothorax have not been we...

    Aria Hong, Christopher S. King, A. Whitney Walter Brown, Shahzad Ahmad, Oksana A. Shlobin, Sandeep Khandhar, Linda Bogar, Anthony Rongione and Steven D. Nathan

    Multidisciplinary Respiratory Medicine 2016 11:40

    Published on: 15 November 2016

  16. Original research article

    Respiratory illness and air pollution from the steel industry: the case of Piquiá de Baixo, Brazil (Preliminary report)

    This report is based on an independent study carried out by medical professionals of the Fondazione IRCCS Istituto Nazionale dei Tumori (National Cancer Institute) in Milan, Italy, and  aimed to assess the inc...

    Carla Valenti, Paolo Pozzi, Alessandra Busia, Roberto Mazza, Paolo Bossi, Cinzia De Marco, Ario Alberto Ruprecht, Alessandro Borgini and Roberto Boffi

    Multidisciplinary Respiratory Medicine 2016 11:41

    Published on: 9 November 2016

  17. Original research article

    Efficacy of recombinant human soluble thrombomodulin for the treatment of acute exacerbation of idiopathic pulmonary fibrosis: a single arm, non-randomized prospective clinical trial

    Coagulation abnormalities are involved in the pathogenesis of acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF). The administration of recombinant human soluble thrombomodulin (rhTM), which has bot...

    Sho Hayakawa, Yasuo Matsuzawa, Tamako Irie, Hagino Rikitake, Noriaki Okada and Yasuo Suzuki

    Multidisciplinary Respiratory Medicine 2016 11:38

    Published on: 7 November 2016

  18. Letter to the Editor

    Cost comparison of asthma treatments in 12-week study: caution about matching and short observational follow-up

    In the absence of randomisation, observational studies must take extra care to create treatment groups that are comparable in terms of key characteristics. Various matching methods exist which can create sound...

    David B. Price, Job F. M. van Boven, Lisa M. Law, Alessandra Cifra and R. Brett McQueen

    Multidisciplinary Respiratory Medicine 2016 11:39

    Published on: 2 November 2016

  19. Review

    Asthma-related deaths

    Despite major advances in the treatment of asthma and the development of several asthma guidelines, people still die of asthma currently. According to WHO estimates, approximately 250,000 people die prematurel...

    Gennaro D’Amato, Carolina Vitale, Antonio Molino, Anna Stanziola, Alessandro Sanduzzi, Alessandro Vatrella, Mauro Mormile, Maurizia Lanza, Giovanna Calabrese, Leonardo Antonicelli and Maria D’Amato

    Multidisciplinary Respiratory Medicine 2016 11:37

    Published on: 12 October 2016

  20. Original research article

    The effect of positive airway pressure therapy on neurocognitive functions, depression and anxiety in obesity hypoventilation syndrome

    The aim of this study is to evaluate the presence of neurocognitive dysfunctions, depression and anxiety and the effect of positive airway pressure (PAP) therapy on these alterations in Obesity Hypoventilation...

    Serap Argun Baris, Dilek Tuncel, Cigdem Ozerdem, Huseyin Kutlu, Tugba Onyilmaz, Ilknur Basyigit, Hasim Boyaci and Fusun Yildiz

    Multidisciplinary Respiratory Medicine 2016 11:35

    Published on: 11 October 2016

  21. Original research article

    Preliminary study on the assessment of visceral adipose tissue using dual-energy x-ray absorptiometry in chronic obstructive pulmonary disease

    Visceral adipose tissue (VAT) was shown to be increased in patients with chronic obstructive pulmonary disease (COPD) compared to control subjects with comparable body mass index (BMI). Our aim was to determin...

    Francesca De Blasio, Erica P. A. Rutten, Emiel F. M. Wouters, Luca Scalfi, Francesco De Blasio, Marco A. Akkermans, Martijn A. Spruit and Frits M. E. Franssen

    Multidisciplinary Respiratory Medicine 2016 11:33

    Published on: 4 October 2016

  22. Original research article

    Cough: impact, beliefs, and expectations from a national survey

    Cough is one of the most common discomforts affecting general population, which can disrupt subjects’ quality of life due to its physical, social, and psychological effects. Aim of the study was to investigate...

    Roberto W. Dal Negro, Massimiliano Mazzolini, Paola Turco and Alessandro Zanasi

    Multidisciplinary Respiratory Medicine 2016 11:34

    Published on: 27 September 2016

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