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Table 2 Cough caused by eosinophilic airway diseases

From: Cough variant asthma and atopic coughAsma variante con tosse e tosse atopica

  Asthma Cough variant asthma Atopic cough Eosinophilic bronchitis
Symptoms Cough, breathlessness, wheeze Cough only Cough only Cough and sputum
Atopy Common Common Common As in general population
Variable airflow obstruction + ± - -
Airway hyper-responsiveness + + - -
Capsaicin cough hyper-responsiveness ± ± - +
Bronchodilator response + + - -
Corticosteroid response + + + +
Response to H1 antagonist ± ± + NK
Progression to asthma n/a 30% rare 10%
Sputum eosinophilia (> 3%) Frequent Frequent Frequent Always (by definition)
Submucosal eosinophils
BAL eosinophilia
Mast cells in ASM NK
Basement membrane thickness NK
  1. Definition of abbreviations: ASM, airway smooth muscle; BAL, bronchoalveolar lavage; n/a, not applicable; NK, not known.
  2. + = often present.
  3. ± = sometimes present.
  4. - = not present.
  5. ↑ = increased.
  6. ↓ = not increased.