Skip to main content

Table 2 Some important drugs that inhibit cytochrome P450 dependent CYP3A4 and CYP2D6

From: Iatrogenic Cushing’s syndrome with inhaled steroid plus antidepressant drugs

CYP2D6 CYP3A4
Antiarrhythmics (Flecainide, Propafenone, etc.) Antiarrhythmics (Amiodarone, Lidocaine, Propafenone, etc.)
Beta blockers (Carvedilol, Metoprolol, etc..) Anti-histamines (Astemizole, Chlorpheniramine)
Neuroleptics (Haloperidol, Risperidone, Clozapine, etc.) Anti-cancer (Tamoxifen, Vinblastine)
Opiates (Dextromethorphan, Codeine, Tramadol, etc.) Benzodiazepines (Midozalam, Diazepam, Alprazolam, etc.)
SSRI (Fluoxetine, Paroxetine, Fluvoxamine, etc.) HIV-protease inh (Ritonavir, Indinavir, etc.)
Tricyclic antidepressants (Amitriptyline, Desipramine, Imipramine, Nortriptyline, etc.) HMG CoA reductaseinh (Atorvastatin, Lovastatine, Simvastatin)
Hormones (Cortisol, Progesterone, Testosterone, steroids)
Calcium channel blocker (Diltiazem, Verapamil, Nitrendipin)
Macrolides (Erythromycin, Clarithromycin)
Others (Ketoconazole, Itraconazole, Lidocaine, Cocaine,…etc)