BMI can influence adult males’ and females’ airway hyperresponsiveness differently

Table 4 Spearman and partial correlation (r) between PD ₂₀ and BMI in males and females with different AHR levels divided into various sub-groups

	All males with AHR	All females with AHR	Males with severe AHR	Females with severe AHR	Males with moderate AHR	Females with moderate AHR	Males with mild AHR	Females with mild AHR
*All subjects with AHR (n. 2520)*	−0.003	−0.033	0.105*	0.067	−0.086	−0.115	−0.041	0.029
*Aged 18–26 years (n. 767)*	−0.038	−0.072	0.074	0.229	−0.066	−0.257*	−0.113	0.030
*Aged 27–44 years (n. 999)*	−0.031	−0.113°	0.062	−0.082	−0.135	−0.210^#	−0.133	−0.088
*Age≥45 years (n. 754)*	0.092	−0.001	0.268*	0.076	0.092	−0.091	0.067	0.025
*Non-smokers (n. 1683)*	0.016	−0.012	0.101	0.069	−0.032	−0.116*	−0.084	−0.016
*Smokers (n. 521)*	−0.082	−0.057	0.185	0.216*	−0.239*	−0.111	0.099	0.048
*Underweight (n. 53)*	−0.30	0.288	-	−0.115	−0.100	0.587*	−0.500	−0.248
*Normal weight (n. 1352)*	0.011	−0.004	−0.024	−0.011	0.030	−0.061	−0.049	−0.016
*Overweight (n. 770)*	0.015	0.120*	0.038	0.070	−0.013	0.115	0.102	0.021
*Obese (n. 345)*	−0.065	0.098	0.018	−0.177	0.087	−0.097	−0.154	−0.044
*All subjects with AHR* ¹ *(n 2198)*	−0.060	−0.050	0.104	0.042	−0.088	−0.161^#	−0.113*	−0.032

Subjects with AHR = PD₂₀ < 3200 μg; Severe AHR = PD₂₀ ≤ 200 μg; moderate AHR = PD₂₀ > 200 and ≤ 800 μg; mild AHR = PD₂₀ > 800 μg; *p < 0.05; °p < 0.01; ^#p < 0.001; ¹correct for age, smoking habits, FEV₁ and FVC, calculated on subjects where the smoking history was known.

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