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Table 1 Demographic characteristics and respiratory function test results of the study population

From: Value of serum and induced sputum surfactant protein-D in chronic obstructive pulmonary disease

 

Group 1 (control subjects)

Group 2 (stage 1 and 2 COPD patients)

Group 3 (stage 3 and 4 COPD patients)

P

 

(n = 20)

(n = 20)

(n = 20)

 

Mean Age (year)

44.85 ± 5.80

60.35 ± 9.40

63.70 ± 8.60

p = 0.001

Gender (F/M)

8/12

0/20

3/17

p = 0.004

Mean BMI (kg/m 2 )

33.36 ± 5.70

32.8 ± 6.70

29.6 ± 5.90

p = 0.148

Smoking status

Active smokers

16 (80%)

10 (50%)

2 (10%)

p = 0.001

Ex-smokers

4 (20%)

10 (50%)

18 (90%)

Cigarette pack years

23 ± 13 (20)

51 ± 28 (45)

51 ± 33(45)

p = 0.001

Inhaled steroid use

0

6

18

p = 0.001

Mean FVC (%)

131.5 ± 15.1

101.7 ± 19

76.7 ± 16.8

p = 0.001

Mean FEV 1 (%)

123 ± 14

75.7 ± 16.4

39.7 ± 7.24

p = 0.001

Mean FEV 1 /FVC (%)

78.9 ± 4.8

59.75 ± 10.8

43.3 ± 11.3

p = 0.001

Mean FEF 25-75 (%)

94.5 ± 23.4

33.5 ± 18.6

12.5 ± 4.54

p = 0.001

Mean VC (%)

130 ± 16.9

94.5 ± 19

80.8 ± 19

p = 0.001

Mean RV (%)

120 ± 29

156 ± 37

150 ± 77

p = 0.001

Mean SpO2 (%)

96.6 ± 1.1

94 ± 1.9

92.1 ± 2.1

p = 0.001

Mean CRP level (mg/L)

2.52 ± 2.4

8.3 ± 10

8.1 ± 9.49

p = 0.014

Mean Hb (g/dl)

14.21 ± 1.55

14.7 ± 1.43

14.6 ± 14

p = 0.282

Mean WBC (/μL)

7.449 ± 1.704

7.291 ± 1.084

8.402 ± 1.694

p = 0.102

Mean PMNL (/μL)

4.272 ± 1.166

4.310 ± 956

5.519 ± 1.205

p = 0.003

  1. The results are expressed as mean ± standard deviation.
  2. BMI Body mass index, CRP C-reactive protein, FEV 1 forced expiratory volume, FRC functional residual capacity, FVC forced vital capacity, Hb hemoglobin, PMNL polymorphonucleer leukocyte, RV residual volume, TLC total lung capacity, VC vital capacity, WBC white blood cell count.