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Table 1 Review of epidermal growth factor receptor gene mutation in patients with high-grade neuroendocrine carcinoma and its combination with other types

From: Large-cell neuroendocrine carcinoma of lung with epidermal growth factor receptor (EGFR) gene mutation and co-expression of adenocarcinoma markers: a case report and review of the literature

Authors

Age

Gender

Smoking

Stage

Cell type

Specimen

Activating EGFR mutation

Okamoto et al. (2006)

72

F

No

IV

SCLC

biopsy

exon 19, del E746-A750

Zakowski et al. (2006)

45

F

No

IV

ADC → SCLC

biopsy

exon 19, del L747-P753insQ

Morinaga et al. (2007)

46

F

No

IIIB

ADC → SCLC

biopsy

exon 19, del E746-A750

Fukui et al. (2007)

62

F

No

IIIB

combined SCLC and ADC

resection

exon 21, L858R mutaion

Tatematsu et al. (2008)

36

F

No

IV

combined SCLC and ADC

resection

exon 21, L858R mutaion

 

81

M

Yes

IV

SCLC

biopsy

exon 18, G719A point mutation

 

69

M

Yes

IA

combined SCLC and ADC

biopsy

exon 21, L858R mutaion

 

89

F

Yes

IB

SCLC

biopsy

exon 21, L858R mutaion

 

65

M

Yes

IIA

combined SCLC and ADC

resection

exon 19, 15-bp deletion

Alam et al. (2010)

73

F

No

IV

ADC (lung), SCLC (liver)

biopsy

exon 21, L858R mutaion

Shiao et al. (2011)

63

M

Yes

III

SCLC

biopsy

exon 19 deletion (del E746-S752 insV)

 

54

F

No

II - III

SCLC

biopsy

exon 19 deletion (del E746-A750)

Sequist et al. (2011)

67

F

NA

NA

ADC → SCLC

biopsy

exon 21, L858R mutaion

 

54

F

NA

NA

ADC → SCLC

biopsy

exon 19 deletion

 

56

F

NA

IV

ADC → SCLC

biopsy

exon 21, L858R mutaion

 

40

F

NA

NA

ADC → SCLC

biopsy

exon 19 deletion

 

61

F

NA

NA

ADC → SCLC

biopsy

exon 21, L858R mutaion

Iyoda et al. (2011)

NA

NA

NA

NA

LCNEC

resection

exon 18, codon 725 (ACG to ACA)

De Pas et al. (2011)

66

M

No

IV

LCNEC

biopsy

exon 19 deletion (p.L747_A755>AT)

Yanagisawa et al. (2012)

46

M

No

IIIA

ADC → LCNEC

resection → biopsy

exon 19 micro-deletion

Lu et al. (2012)

61

M

Yes

IIA

combined SCLC and SQCC

resection

exon 19, del E746-A750 (K745 AAA)

 

62

F

No

IIIA

combined SCLC and ADC

resection

exon 19, del E746-A750 (K745 AAA)

Lu et al. (2012)

62

F

No

IIIA

combined SCLC and ADC

resection

exon 19 mutation, codon 746-754

Our case (2012)

78

F

Yes (Ex)

IV

LCNEC

brushing

exon 21, L858R mutaion

  1. ADC, adenocarcinoma; EGFR, epidermal growth factor receptor, F, female; LCNEC, large-cell neuroendocrine carcinoma; M, male; NA, not available; SCLC, small-cell lung cancer; SQCC, squamous cell carcinoma.