Invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease

Table 3 Diagnosis, antifungal therapy, and outcomes in 11 COPD patients with IPA

	Diagnosis	Risk factor^a	Chest x-ray	Thorax CT	Type of specimen	Isolation type	Antifungal treatment	GM value and control (ng/mL)	Beta D- Glucan (pg/mL)	Death
1	Probable	Steroid	Infiltration, cavitation	Infiltration, cavity	Sputum, pleural fluid	A. niger	LAMB	3.79 → 0.24	none	Yes
2	Probable	Steroid	Infiltration	Infiltration	Bronchial lavage	A. fumigatus	LAMB	0.53 → none	none	Yes
3	Probable	Steroid	Cavitation	Cavity	Sputum	Aspergillus species	AMB	3.79 → 2.33	none	Yes
4	Probable	Steroid and antibiotic	Infiltration	Infiltration, consolidation	Sputum and bronchial lavage	Aspergillus species	AMB	9.16→ none	none	Yes
5	Probable	Steroid	Consolidation	Consolidation	Bronchial lavage	A. niger	AMB	5.48 → 4.38	none	Yes
6	Probable	Steroid	Cavitation, nodule	Infiltration, cavity, nodule	Sputum	A. fumigatus	AMB	0.22 → none	> 523	Yes
7	Proven^b	Steroid and antibiotic	Consolidation, nodule	Consolidation, nodule	Sputum	A. fumigatus	AMB, then voriconazole	0.54 → 0.33	59	No
8	Proven^b	Antibiotic	Infiltration	Infiltration, nodule	Bronchial lavage	A. fumigatus	AMB, then voriconazole	0.60 → 0.30	none	No
9	Probable	Steroid	Infiltration	Infiltration	Bronchial lavage	A. fumigatus	AMB, then voriconazole	0.50 → 0.16	51	No
10	Probable	Steroid	Infiltration, nodule	Infiltration, nodule	Sputum	A. niger	LAMB, then voriconazole	0.17 → none	90	No
11	Proven^b	Steroid and antibiotic	Infiltration	Infiltration	Transbronchial biopsy	A. fumigatus	LAMB, then voriconazole	0.39 → none	> 523	No

^aThe term Steroid includes only systemic corticosteroid treatment.
^bHyphae were seen in the pathological examination of biopsy material.
AMB, Amphotericin B deoxycholate; IPA, Invasive pulmonary aspergillosis; LAMB, Liposomal amphotericin B.

ISSN: 2049-6958