Percentage of patients with dynamic changes in viral status between visit 1 and visit 2. “Deterioration” was defined as > 50-fold increase of viral titer at visit 2 or detection of a new virus which was not revealed at visit 1. “Improvement” was defined as a > 50-fold decrease of viral titer at visit 2 or the elimination of a virus which was present at visit 1. “No change” was defined as a viral titer between 1:50 to 50:1 at visit 2 compared to visit 1. A: a ITT population p = 0.005 B: PP population p = 0.009.