Table 5 Negative consequences of non-adherence

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Poor control of symptoms

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Worsening of the quality of life

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Increasing number of relapses and more frequent need for health-care services (which account for 35-45% of the disease-related costs)

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Higher mortality rate (2–3 times higher than in patients showing good compliance – 26.4% vs. 11.3% according to a sub-analysis made in the TORCH study [28]

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Increase in health-care expenditure.