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Table 5 Negative consequences of non-adherence

From: COPD: adherence to therapy

Poor control of symptoms
Worsening of the quality of life
Increasing number of relapses and more frequent need for health-care services (which account for 35-45% of the disease-related costs)
Higher mortality rate (2–3 times higher than in patients showing good compliance – 26.4% vs. 11.3% according to a sub-analysis made in the TORCH study [28]
Increase in health-care expenditure.