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Table 7 Cox regression analysis of survival according to categorisation of variables < vs. > the median value

From: Mental health, serum biomarkers and survival in severe COPD: a pilot study

Explanatory Variable

HR (95 % CI)

*p

Univariate analysis

 PHQ-stress

4.92 (1.06-22.85)

0.042

 Leucocytes

2.97 (1.06-8.36)

0.038

 6-MWD (%)

2.07 (0.6-7.07)

0.248

 BMI

0.77 (0.30-1.95)

0.58

 FEV1, % predicted

1.51 (0.59-3.89)

0.395

Multivariate analyses

Model I

  

 6-MWD (%)

19.58 (1.01-380.75)

0.049

 BMI

48.73 (1.21-1969.65)

0.039

 FEV1, % predicted

3.37 (0.35-32.55)

0.295

 PHQ-stress

45.63 (1.72-1,208.48)

0.022

Model 2

 6-MWD (%)

2.6 (0.71-9.57)

0.151

 BMI

1.34 (0.38-4.79)

0.650

 FEV1, % predicted

1.03 (0.25-4.18)

0.970

 Leucocytes

3.41 (0.91-12.85)

0.069

  1. *Only the significant (p ≤ 0.05) univariate variables for physical function, demographic data and biomarkers are shown. Model 1 and 2: Cox proportional hazard model (method: stepwise backward likelihood ratio) including known risk factors for survival in COPD (6-MWD, body mass index, FEV1, (% predicted)) as well as PHQ-stress (model 1) and leucocytes (model 2)
  2. PHQ Patient Health Questionnaire, &-MWD six-minute walk test, BMI body mass index, FEV1 forced expiratory volume in 1 s
  3. Highlighted in bold: p ≤ 0.05
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Multidisciplinary Respiratory Medicine

ISSN: 2049-6958

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