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Fig. 2 | Multidisciplinary Respiratory Medicine

Fig. 2

From: Longitudinal assessment of bleomycin-induced lung fibrosis by Micro-CT correlates with histological evaluation in mice

Fig. 2

Quantitative histological analysis of lung fibrosis progression in bleomycin mouse model. Representative images of Trichromic Masson-staining of mice lung sections: of saline and bleomycin-treated mice over time. a saline, (b, c and d). Bleomycin treated mice at 7–14 and 21 respectively used for the quantification (10×). Bars: 200 μm. Time course of disease progression of saline and bleomicyn-treated mice at 7, 14 and 21 days: e Ashcroft’s score criteria, f Alveolar Air area percentage and g Collagen content percentage. The experiment was repeated three times and each point presents the mean ± s.e.m of 10 animals, for total of 60 mice per experimental session. Changes were compared to the saline group using one-way ANOVA followed by Dunnett’s t test for multiple comparison. *p < 0.05; **p < 0.01

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