Fig. 1
From: The evidence on tiotropium bromide in asthma: from the rationale to the bedside
Possible role of tiotropium bromide in the management of asthma. The colour code refers to the functional and clinical characteristics that tiotropium should be able to modify according to its pharmacological properties. If the effect on functional and clinical asthma domains is effected prevalently by specific tiotropium properties, the effect on asthma control and future risk might be modulated by the concomitant action of different characteristics taken together. Th2, T helper-2 lymphocytes; SM, smooth muscle cells; MUC5AC, mucin-5 subtype AC gene; QoL, Quality of Life; ACQ-7, Asthma Control Questionnaire