From: The evidence on tiotropium bromide in asthma: from the rationale to the bedside
Authors | Year | Main inclusion criteria | Age | Number | Treatment | Duration | Primary outcome | Secondary outcomes | Conclusions |
---|---|---|---|---|---|---|---|---|---|
Vogelberg C et al. [123] | 2015 | FEV1 60–90%pred. Symptomatic with ACQ-7 > 1.5 and treatment with 200–400 μg of budesonide or eq. +/− LABA +/− LTRA | 6–11 | 101 | Add on tiotropium 1.25 μg, 2.5 μg, 5 μg or placebo to medium-dose ICS with or without LTRA | 12 weeks | Peak FEV1(0–3 h) | 1) Trough FEV1 2) Trough FVC 2) FEV1AUC (0–3h) 3) morning/evening PEF 4) ACQ-7 5) PAQLQ (S) | All doses were superior to placebo in all outcomes. No difference between doses. |
Vogelberg C et al. [124] | 2014 | FEV1 60–90%pred. Symptomatic with ACQ-7 > 1.5 | 12–17 | 105 | Add on tiotropium 1.25 μg, 2.5 μg, 5 μg or placebo to medium-dose ICS with or without LTRA | 4 weeks | Peak FEV1(0–3 h) | 1) Trough FEV1 2) FEV1AUC (0–3h) 3) Morning/evening PEF 4) ACQ-7 | The response of Tiotropium 5 μg dose is superior compared to placebo and greater than tiotropium 1.25 and 2.5 μg |
Kerstjens HA et al. [125] | 2011 | Severe persistent asthma FEV1 < 80%pred. ACQ-7 > 1.5 and high dose ICS (≥800 μg budesonide or eq.) + LABA +/− teophylline, LTRA or OCS | 18–75 | 100 | Add on tiotropium 5 μg vs 10 μg vs placebo | 24 weeks | Peak FEV1(0–3 h) | 1) Trough FEV1 2) Peak FVC 3) FVC AUC (0–3h) 4) Trough FVC 5) FEV1AUC (0–3h) 6) morning/evening PEF 7) Mini AQLQ 8) rescue medication use 9) asthma symptoms 10) symptom free days | Compared with placebo, both tiotropium doses were superior in all outcomes. There was no difference between doses. |
Beeh KM et al. [128] | 2014 | FEV1 60–90%pred. Symptomatic with ACQ-7 > 1.5 and medium dose ICS +/− LABA +/− SABA | 18–75 | 141 | Add on tiotropium 1.25 μg vs 2.5 μg vs 5 μg vs placebo | 12 weeks | Peak FEV1(0–3 h) | 1) Trough FEV1 2) Peak FVC (0–3 h) 3) FVC AUC (0–3h) 4) Trough FVC 5) FEV1AUC (0–3h) 6) morning/evening PEF 7) ACQ 7 | Compared with placebo, all tiotropium doses were superior in all outcomes. The largest response was obtained with 5 μg |
Timmer W et al. [127] | 2015 | FEV1 60–90%pred. Symptomatic with ACQ-7 > 1.5 and medium dose ICS +/− LABA +/− SABA | 18–75 | 89 | Add on tiotropium 5 μg OD vs 2.5 μg BID vs placebo | 12 weeks | FEV1AUC (0–24) | 1) Peak FEV1 (0–24 h) 2) Trough FEV1 3) morning/evening PEF 4) ACQ-7 | Both tiotropium doses are superior to placebo in all outcomes. No advantage of BID administration. |
Ohta K et al. [129] | 2015 | FEV1 60–90%pred. Symptomatic despite 400–800 μg budesonide or eq. +/− LABA | 18–75 | 285 | Add on tiotropium 2.5 μg, 5 μg or placebo to ICS +/− maintenance therapy | 52 weeks | Long term safety | 1) Trough FEV1 2) Trough FVC 3) Trough PEF 4) ACQ-7 | No difference in AEs rate between groups |