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Table 1 Means (sd) of emitted dose velocity for each MDI and for the SMI, at different canister filling and distance from the nozzle. Anova for comparisons

From: Instant velocity and consistency of emitted cloud change by the different levels of canister filling with Metered Dose Inhalers (MDIs), but not with Soft Mist Inhalers (SMIs): a bench study

  

5 cm

10 cm

20 cm

Anova p

MDI A

90%

35.5 (7.9)

23.1 (1.6)

12.5 (1.5)

0.001

 

50%

30.2 (10.0)

21.8 (2.4)

7.2 (6.4)

0.001

 

10%

27.5 (9.7)

21.7 (2.3)

3.9 (6.2)

0.001

Anova p

 

<0.037

ns

<0.05

 

MDI B

90%

63.1 (9.7)a

51.3 (5.7)

32.1 (2.4)

0.001

 

50%

60.0 (9.3)a

51.7 (11.5)

31.4 (4.5)

0.001

 

10%

42.3 (6.4)

33.3 (1.5%)

18.4 (0–9)

0.001

Anova p

 

<0.001

<0.001

<0.001

 

MDI C

90%

47.4 (7.7)

28.1 (2.5)

17.9 (2.4)

0.001

 

50%

40.5 (7.4)

25.5 (1.7)

16.7 (2.4)

0.001

 

10%

37.7 (4.8)

27.9 (3.5)

17.8 (2.1)

0.001

Anova p

 

ns

ns

ns

 

MDI D

90%

40.7 (11.7)

22.2 (1.4)

12.2 (0.8)

0.001

 

50%

36.4 (6.9)

20.1 (2.0)

11.7 (1.1)

0.001

 

10%

31.3 (3.7)

19.3 (1.6)

10.7 (1.2)

0.001

Anova p

 

<0.005

ns

<0.05

 

MDI E

90%

45.0 (4.1)

32.0 (3.3)

17.2 (1.4)

0.001

 

50%

41.4 (7.1)

29.3 (5.0)

16.1 (1.5)

0.001

 

10%

31.2 (9.7)

21.7 (1.7)

12.9 (2.7)

0.001

Anova p

 

<0.001

<0.01

<0.02

 

SMI

90%

5.7 (0.5)b

3.6 (0.5)

1.8 (0.4)

0.001

 

50%

5.2 (1.6)b

3.5 (0.9)

1.8 (0.5)

0.001

 

10%

5.0 (1.3)b

3.3 (1.1)

1.6 (0.7)

0.001

Anova p

 

ns

ns

ns

 
  1. aMDI A generated the highest value for instant velocity at 90% and 50% of canister filling (p < 0.001)
  2. bSMI generated the lowest value for instant velocity at 90%, 50%, and 10% of canister filling (all p < 0.001)