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Table 2 Means ± sd of time (sec.); area (cm2), and perimeter (cm) of the clouds calculated for each device at 10 and 20 cm from the nozzle. ANOVA for comparisons

From: Instant velocity and consistency of emitted cloud change by the different levels of canister filling with Metered Dose Inhalers (MDIs), but not with Soft Mist Inhalers (SMIs): a bench study

 

10 cm

20 cm

 

t sec

Area cm2

Perimeter cm

t sec

Area cm2

Perimeter cm

MDI A

0.011 (0.001)

13.71 (2.13)

20.54 (0.53)

0.05 (0.019)

71.10 (2.81)

45.05 (1.93)

MDI B

0.012 (0.01)

9.31a (0.56)

19.19a (0.55)

0.053 (0.01)

64.43 (2.50)

41.68 (1.30)

MDI C

0.011 (0.001)

16.72 (8.18)

21.87 (1.63)

0.03 (0.01)

52.42 (6.72)

43.1 (1.87)

MDI D

0.035 (0.021)

18.53 (4.61)

23.22 (1.33)

0.03 (0.01)

75.35 (2.41)

48.88 (2.84)

MDI E

0.03 (0.04)

20.48 (1.71)

24.24 (2.79)

0.05 (0.04)

59.46 (2.19)

47.01 (1.27)

SMI

0.29b (0.04)

66.20b (8.94)

38.68b (11.14)

0.83b (0.39)

130.08b (5.71)

68.35b (10.71)

  1. aMDI B generated the tightest area and perimeter at 10 cm from the nozzle (ANOVA p < 0.001)
  2. bSMI generated the widest areas and perimeters at 10 and 20 cm from the nozzle, with the slowest jet and cloud phase (ANOVA, all 0.001)