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Table 6 Clinical efficacy studies: Rhinosinusitis

From: Role of guaifenesin in the management of chronic bronchitis and upper respiratory tract infections

First Author (Year) Objectives of study Intervention Results
Wawrose (1992) To evaluate the role of guaifenesin in decreasing symptoms of postnasal drainage and nasal congestion in HIV+ patients with chronic rhinosinusitis Double-blind parallel-group study:
1200 mg guaifenesin vs placebo 2× daily for 3 weeks
Significantly less nasal congestion and thinner postnasal drainage reported after 3 weeks of treatment with guaifenesin vs placebo (p < 0.05)
Rosen (2005) To evaluate the effect of guaifenesin on mucociliary clearance time (MCT) and sinonasal symptoms in HIV+ patients Randomized double-blind parallel-group study:
1200 mg guaifenesin vs placebo 2× daily for 3 weeks
Significant improvement in sinonasal symptom survey (SNOT-16) score in HIV+ patients treated with guaifenesin vs placebo (p < 0.05)