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Table 2 Biomarkers in the Lung cancer, COPD and Control Groups

From: Non-typeable Haemophilus Influenzae detection in the lower airways of patients with lung cancer and chronic obstructive pulmonary disease

Biomarker Lung Cancer COPD Control
N = 20 N = 27 N = 13
Serum,
 Total IgG ng/ml (mean ± SE) 6.87 ± 0.38** 5.36 ± 0.39 5.97 ± 0.51
 Total IgE, ng/ml (median ± IQR) 243 ± (181.3–305.5)†, ** 172.5 ± (95.5–297.8)* 91.0 ± (69.5–266.5)
 IgG to NTHi OMP, RU (mean ± SE) 2.10 ± 0.22 2.02 ± 0.16 1.74 ± 0.24
 IgG to NTHi P6, (mean ± SE) 1.55 ± 0.13 1.62 ± 0.10 1.32 ± 0.07
Bronchial wash (n (%)
 NTHi Culture positive 2 (10) 6 (22) 1 (8)
 NTHi PCR positive 5 (20) 6 (22) 2 (15)
PPM
 Staphylococcus aureus   1  
 Streptococcus pneumoniae   1  
 Pseudomonas aeruginosa   2  
 Stenotrophomonas maltophilia   1  
Non-PPM
 Atypical Mycobacterium    1
 Aspergillus fumigatus 1 1  
 No microorganism 17 16 11
  1. *p < 0.05 between COPD and controls; † p < 0.05 between Lung Cancer and controls; ** p < 0.05 between Lung Cancer and COPD
  2. PPM-Potential Pathogenic Organisms