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Table 2 Biomarkers in the Lung cancer, COPD and Control Groups

From: Non-typeable Haemophilus Influenzae detection in the lower airways of patients with lung cancer and chronic obstructive pulmonary disease

Biomarker

Lung Cancer

COPD

Control

N = 20

N = 27

N = 13

Serum,

 Total IgG ng/ml (mean ± SE)

6.87 ± 0.38**

5.36 ± 0.39

5.97 ± 0.51

 Total IgE, ng/ml (median ± IQR)

243 ± (181.3–305.5)†, **

172.5 ± (95.5–297.8)*

91.0 ± (69.5–266.5)

 IgG to NTHi OMP, RU (mean ± SE)

2.10 ± 0.22

2.02 ± 0.16

1.74 ± 0.24

 IgG to NTHi P6, (mean ± SE)

1.55 ± 0.13

1.62 ± 0.10

1.32 ± 0.07

Bronchial wash (n (%)

 NTHi Culture positive

2 (10)

6 (22)

1 (8)

 NTHi PCR positive

5 (20)

6 (22)

2 (15)

PPM

 Staphylococcus aureus

 

1

 

 Streptococcus pneumoniae

 

1

 

 Pseudomonas aeruginosa

 

2

 

 Stenotrophomonas maltophilia

 

1

 

Non-PPM

 Atypical Mycobacterium

  

1

 Aspergillus fumigatus

1

1

 

 No microorganism

17

16

11

  1. *p < 0.05 between COPD and controls; † p < 0.05 between Lung Cancer and controls; ** p < 0.05 between Lung Cancer and COPD
  2. PPM-Potential Pathogenic Organisms