Fig. 2From: 5-hydroxymethylcytosine but not MTAP methylation status can stratify malignant pleural mesothelioma based on the lineage of originPanel A. Immunohistochemistry staining for INK4 locus. A. INK4 locus immunohistochemistry staining of sample 4, group +/−. B. INK4 locus immunohistochemistry staining of sample 3, group ++. C. INK4 locus immunohistochemistry staining of sample 47, group +++. Panel B. Immuno-staining groups and relative percentages (40 + 90 cases analyzed). Panel C. Sensitivity and quantitative accuracy of MTAP SMART-MSP assay (90 cases analyzed). Top: The assay was sensitive to 0,1% methylation in a background of WGA. Bottom: The assay was quantitative accurate in the range 100% methylation to 0,1% methylation (R2 = 0,99,393). The PCR efficiency was 0,95Back to article page