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Fig. 2 | Multidisciplinary Respiratory Medicine

Fig. 2

From: 5-hydroxymethylcytosine but not MTAP methylation status can stratify malignant pleural mesothelioma based on the lineage of origin

Fig. 2

Panel A. Immunohistochemistry staining for INK4 locus. A. INK4 locus immunohistochemistry staining of sample 4, group +/−. B. INK4 locus immunohistochemistry staining of sample 3, group ++. C. INK4 locus immunohistochemistry staining of sample 47, group +++. Panel B. Immuno-staining groups and relative percentages (40 + 90 cases analyzed). Panel C. Sensitivity and quantitative accuracy of MTAP SMART-MSP assay (90 cases analyzed). Top: The assay was sensitive to 0,1% methylation in a background of WGA. Bottom: The assay was quantitative accurate in the range 100% methylation to 0,1% methylation (R2 = 0,99,393). The PCR efficiency was 0,95

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