Table 1 When and how rule out CF according to existing bronchiectasis guidelines
From: When and how ruling out cystic fibrosis in adult patients with bronchiectasis
Guidelines | When | How |
|---|---|---|
ERS 2017 [14] | Selected adults including those with any of the following: young adults; upper lobe predominance of bronchiectasis on chest CT; the presence of nasal polyposis and/or chronic rhinosinusitis; recurrent pancreatitis; male primary infertility and/or malabsorption | Sweat chloride, other biomarkers of CFTR activity and CFTR mutation analysis |
Pulmonology Portoguese Society, 2016 [16] | All children and selected adults (no further specified) | Two measurements of sweat chloride and CFTR mutation analysis for |
British Thoracic Society, 2010 [22] | All children and selected adults including those with any of the following: adults up to the age of 40; age at presentation > 40 years and no other identified cause; persistent isolation of Staphylococcus aureus in the sputum; features of malabsorption; male primary infertility; upper lobe bronchiectasis; a history of childhood steatorrhoea. | Two measurements of sweat chloride and CFTR mutation analysis |
Normativa SEPAR, 2008 [23] | Selected adults | Sweat chloride, nasal potential difference, CFTR mutation analysis test |
Thoracic Society of Australia and New Zealand, 2015 [24] | All children and selected adults (no further specified) | Sweat test |