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Table 1 When and how rule out CF according to existing bronchiectasis guidelines

From: When and how ruling out cystic fibrosis in adult patients with bronchiectasis

Guidelines When How
ERS 2017 [14] Selected adults including those with any of the following: young adults; upper lobe predominance of bronchiectasis on chest CT; the presence of nasal polyposis and/or chronic rhinosinusitis; recurrent pancreatitis; male primary infertility and/or malabsorption Sweat chloride, other biomarkers of CFTR activity and CFTR mutation analysis
Pulmonology Portoguese Society, 2016 [16] All children and selected adults (no further specified) Two measurements of sweat chloride and CFTR mutation analysis for
British Thoracic Society, 2010 [22] All children and selected adults including those with any of the following: adults up to the age of 40; age at presentation > 40 years and no other identified cause; persistent isolation of Staphylococcus aureus in the sputum; features of malabsorption; male primary infertility; upper lobe bronchiectasis; a history of childhood steatorrhoea. Two measurements of sweat chloride and CFTR mutation analysis
Normativa SEPAR, 2008 [23] Selected adults Sweat chloride, nasal potential difference, CFTR mutation analysis test
Thoracic Society of Australia and New Zealand, 2015 [24] All children and selected adults (no further specified) Sweat test