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Table 3 Ranges of susceptibility against penicillin-susceptible (≤0.06 mg/l), penicillin-intermediate and penicillin-resistant (≥2 mg/l) pneumococcal isolates, calculated with MIC distributions from published studies [41,42,43,44,45] by applying CLSI breakpoints (amoxicillin, cefuroxime) and the three proposed breakpoints for cefditoren

From: Revisiting cefditoren for the treatment of community-acquired infections caused by human-adapted respiratory pathogens in adults

Antibiotic Penicillin susceptible isolates Penicillin intermediate isolates Penicillin resistant isolates
Amoxicillina (≤2 mg/l) 100% 78.4–100% 17.5–76%
Cefuroxime (≤1 mg/l) 99.7–100% 33.8–67.6% 0–0.4%
Cefditoren
  ≤ 0.125 mg/l 99.1–100% 37.2–71.2% 0–0.4%
  ≤ 0.25 mg/l 100% 67.6–88.6% 15.2–57.3%
  ≤ 0.5 mg/l 100% 99.3–100% 95.3–100%
  1. aAmoxicillin/clavulanic acid in references [41, 42]