From: Long term management of obstructive sleep apnea and its comorbidities
1st autor, and reference | Design | Sample | Mean Age | Mean follow up | Results |
---|---|---|---|---|---|
Cohort studies published before 1996 | |||||
 He et al.; (Ref. #5) | Retrospective | 385 | 52 | N. A | AI > 20 has a RR mortality of 1.5 vs AI < 20 UPPP vs conservative: no differences |
 Partinen et al.; (Ref. #6) | Retrospective | 198 | 56 | 5 years | Tracheostomy vs conservative 5 years survival: 0% vs 6% |
 Bliwise et al.; (Ref. #7) | Prospective | 298 | 69 | Up 12 years | RR mortality for RDI > 10 of 2.67 (0.95–7.5, 95%CI). |
 Ancoli-Israel et al.; (Ref. #8) | Prospective | 233 | 83 | 3.3 years | Significant association of AHI with death in women but not in men |
 Mant et al.; (Ref. #9) | Prospective | 163 | 83 | 4 years | No relationship between RDI and survival |
 Lavie et al.; (Ref. #10) | Prospective | 1620 | 48 | 12 years | Mortality OR of 1.012 for AI > 10 (not significant) |
Cohort studies published after 1996 | |||||
 Lavie et al.; (Ref. #12) | Prospective | 13,850 | 48 | 4.5 years | HR all-cause mortality, 2.2 for RDI > 30 (significant) |
 Yaggi et al. (Ref. #13) | Prospective | 1022 | 61 | 3.4 years | HR all-cause mortality, 3.3 for AHI > 36 (significant) |
 Marin et al.; (Ref. # 14) | Prospective | 1651 | 50 | 10 years | OR cardiovascular mortality, 2.87 for AHI > 30 (significant) |
 Young et al.; (Ref. #15) | Prospective | 1522 | 48 | 18 years | HR all-cause mortality, 3.8 for AHI > 30 (significant) |
 Marshall et al.;(Ref. #16) | Prospective | 400 | 53 | 20 years | HR all-cause mortality, 4.2 for RDI > 15 (significant) |
 Punjabi et al.; (Ref. #17) | Prospective | 6441 | 63 | 10 years | HR all-cause mortality, 2.09 for AHI > 30 (in men aged 40–70 years) |