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Table 1 Long-term mortality studies in obstructive sleep apnea

From: Long term management of obstructive sleep apnea and its comorbidities

1st autor, and reference Design Sample Mean Age Mean follow up Results
Cohort studies published before 1996
 He et al.; (Ref. #5) Retrospective 385 52 N. A AI > 20 has a RR mortality of 1.5 vs AI < 20 UPPP vs conservative: no differences
 Partinen et al.; (Ref. #6) Retrospective 198 56 5 years Tracheostomy vs conservative 5 years survival: 0% vs 6%
 Bliwise et al.; (Ref. #7) Prospective 298 69 Up 12 years RR mortality for RDI > 10 of 2.67 (0.95–7.5, 95%CI).
 Ancoli-Israel et al.; (Ref. #8) Prospective 233 83 3.3 years Significant association of AHI with death in women but not in men
 Mant et al.; (Ref. #9) Prospective 163 83 4 years No relationship between RDI and survival
 Lavie et al.; (Ref. #10) Prospective 1620 48 12 years Mortality OR of 1.012 for AI > 10 (not significant)
Cohort studies published after 1996
 Lavie et al.; (Ref. #12) Prospective 13,850 48 4.5 years HR all-cause mortality, 2.2 for RDI > 30 (significant)
 Yaggi et al. (Ref. #13) Prospective 1022 61 3.4 years HR all-cause mortality, 3.3 for AHI > 36 (significant)
 Marin et al.; (Ref. # 14) Prospective 1651 50 10 years OR cardiovascular mortality, 2.87 for AHI > 30 (significant)
 Young et al.; (Ref. #15) Prospective 1522 48 18 years HR all-cause mortality, 3.8 for AHI > 30 (significant)
 Marshall et al.;(Ref. #16) Prospective 400 53 20 years HR all-cause mortality, 4.2 for RDI > 15 (significant)
 Punjabi et al.; (Ref. #17) Prospective 6441 63 10 years HR all-cause mortality, 2.09 for AHI > 30 (in men aged 40–70 years)
  1. Abbreviations: AI apnea index RR risk ratio, UPPP uvulopalatopharyngoplasty, AHI apnea-hipopnea index, RDI respiratory disturbance index, OD odds ratio, HR hazard ratio, CVS cardiovascular, OSA obstructive sleep apnea