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Table 1 Long-term mortality studies in obstructive sleep apnea

From: Long term management of obstructive sleep apnea and its comorbidities

1st autor, and reference

Design

Sample

Mean Age

Mean follow up

Results

Cohort studies published before 1996

 He et al.; (Ref. #5)

Retrospective

385

52

N. A

AI > 20 has a RR mortality of 1.5 vs AI < 20 UPPP vs conservative: no differences

 Partinen et al.; (Ref. #6)

Retrospective

198

56

5 years

Tracheostomy vs conservative 5 years survival: 0% vs 6%

 Bliwise et al.; (Ref. #7)

Prospective

298

69

Up 12 years

RR mortality for RDI > 10 of 2.67 (0.95–7.5, 95%CI).

 Ancoli-Israel et al.; (Ref. #8)

Prospective

233

83

3.3 years

Significant association of AHI with death in women but not in men

 Mant et al.; (Ref. #9)

Prospective

163

83

4 years

No relationship between RDI and survival

 Lavie et al.; (Ref. #10)

Prospective

1620

48

12 years

Mortality OR of 1.012 for AI > 10 (not significant)

Cohort studies published after 1996

 Lavie et al.; (Ref. #12)

Prospective

13,850

48

4.5 years

HR all-cause mortality, 2.2 for RDI > 30 (significant)

 Yaggi et al. (Ref. #13)

Prospective

1022

61

3.4 years

HR all-cause mortality, 3.3 for AHI > 36 (significant)

 Marin et al.; (Ref. # 14)

Prospective

1651

50

10 years

OR cardiovascular mortality, 2.87 for AHI > 30 (significant)

 Young et al.; (Ref. #15)

Prospective

1522

48

18 years

HR all-cause mortality, 3.8 for AHI > 30 (significant)

 Marshall et al.;(Ref. #16)

Prospective

400

53

20 years

HR all-cause mortality, 4.2 for RDI > 15 (significant)

 Punjabi et al.; (Ref. #17)

Prospective

6441

63

10 years

HR all-cause mortality, 2.09 for AHI > 30 (in men aged 40–70 years)

  1. Abbreviations: AI apnea index RR risk ratio, UPPP uvulopalatopharyngoplasty, AHI apnea-hipopnea index, RDI respiratory disturbance index, OD odds ratio, HR hazard ratio, CVS cardiovascular, OSA obstructive sleep apnea