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Table 2 Pooled analysis of AEs (sorted by descending order) extracted from the studies that directly compared doxofyline with theophylline in asthmatic patients

From: Efficacy and safety profile of doxofylline compared to theophylline in asthma: a meta-analysis

  Doxofylline Theophylline
Total number of asthmatic patients 228 220
  % n % n
Asthmatic patients reporting at least one AE 46.05 105 57.73 127
Total number of AEs
 headache 20.61 47 23.64 52
 nausea 10.96 25 21.82 48
 nervousness 4.39 10 11.36 25
 insomnia 6.14 14 9.55 21
 dyspepsia 6.58 15 8.18 18
 vomiting 3.51 8 4.09 9
 dizziness 3.95 9 3.18 7
 cough increased 0.44 1 3.64 8
 overdose 0.00 0 3.64 8
 rhinitis 3.51 8 2.73 6
 diarrhoea 3.07 7 3.18 7
 asthma 3.07 7 3.18 7
 abdominal pain 2.63 6 1.82 4
 pharyngitis 1.32 3 2.27 5
 palpitations 2.19 5 1.82 4
 chest pain 2.19 5 0.00 0
 epigastric distress 0.88 2 1.82 4
 asthenia 0.00 0 1.82 4
 tremors 0.00 0 0.91 2
 somnolence 0.44 1 0.45 1
 sore throat 0.00 0 0.45 1
  1. AE adverse event