Table 2 Pooled analysis of AEs (sorted by descending order) extracted from the studies that directly compared doxofyline with theophylline in asthmatic patients
From: Efficacy and safety profile of doxofylline compared to theophylline in asthma: a meta-analysis
| Doxofylline | Theophylline | |||
|---|---|---|---|---|
| Total number of asthmatic patients | 228 | 220 | ||
| % | n | % | n | |
| Asthmatic patients reporting at least one AE | 46.05 | 105 | 57.73 | 127 |
| Total number of AEs | ||||
| headache | 20.61 | 47 | 23.64 | 52 |
| nausea | 10.96 | 25 | 21.82 | 48 |
| nervousness | 4.39 | 10 | 11.36 | 25 |
| insomnia | 6.14 | 14 | 9.55 | 21 |
| dyspepsia | 6.58 | 15 | 8.18 | 18 |
| vomiting | 3.51 | 8 | 4.09 | 9 |
| dizziness | 3.95 | 9 | 3.18 | 7 |
| cough increased | 0.44 | 1 | 3.64 | 8 |
| overdose | 0.00 | 0 | 3.64 | 8 |
| rhinitis | 3.51 | 8 | 2.73 | 6 |
| diarrhoea | 3.07 | 7 | 3.18 | 7 |
| asthma | 3.07 | 7 | 3.18 | 7 |
| abdominal pain | 2.63 | 6 | 1.82 | 4 |
| pharyngitis | 1.32 | 3 | 2.27 | 5 |
| palpitations | 2.19 | 5 | 1.82 | 4 |
| chest pain | 2.19 | 5 | 0.00 | 0 |
| epigastric distress | 0.88 | 2 | 1.82 | 4 |
| asthenia | 0.00 | 0 | 1.82 | 4 |
| tremors | 0.00 | 0 | 0.91 | 2 |
| somnolence | 0.44 | 1 | 0.45 | 1 |
| sore throat | 0.00 | 0 | 0.45 | 1 |