Table 2 Pooled analysis of AEs (sorted by descending order) extracted from the studies that directly compared doxofyline with theophylline in asthmatic patients
From: Efficacy and safety profile of doxofylline compared to theophylline in asthma: a meta-analysis
Doxofylline | Theophylline | |||
|---|---|---|---|---|
Total number of asthmatic patients | 228 | 220 | ||
% | n | % | n | |
Asthmatic patients reporting at least one AE | 46.05 | 105 | 57.73 | 127 |
Total number of AEs | ||||
headache | 20.61 | 47 | 23.64 | 52 |
nausea | 10.96 | 25 | 21.82 | 48 |
nervousness | 4.39 | 10 | 11.36 | 25 |
insomnia | 6.14 | 14 | 9.55 | 21 |
dyspepsia | 6.58 | 15 | 8.18 | 18 |
vomiting | 3.51 | 8 | 4.09 | 9 |
dizziness | 3.95 | 9 | 3.18 | 7 |
cough increased | 0.44 | 1 | 3.64 | 8 |
overdose | 0.00 | 0 | 3.64 | 8 |
rhinitis | 3.51 | 8 | 2.73 | 6 |
diarrhoea | 3.07 | 7 | 3.18 | 7 |
asthma | 3.07 | 7 | 3.18 | 7 |
abdominal pain | 2.63 | 6 | 1.82 | 4 |
pharyngitis | 1.32 | 3 | 2.27 | 5 |
palpitations | 2.19 | 5 | 1.82 | 4 |
chest pain | 2.19 | 5 | 0.00 | 0 |
epigastric distress | 0.88 | 2 | 1.82 | 4 |
asthenia | 0.00 | 0 | 1.82 | 4 |
tremors | 0.00 | 0 | 0.91 | 2 |
somnolence | 0.44 | 1 | 0.45 | 1 |
sore throat | 0.00 | 0 | 0.45 | 1 |