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  1. Inhalation is the preferred route for respiratory drug delivery, but several factors contribute to the variability of the respirable dose fraction. Instant velocity and the dynamic characteristics of the dropl...

    Authors: Roberto W. Dal Negro, Pietro Longo, Orestepaolo Villanis Ziani, Luca Bonadiman and Paola Turco
    Citation: Multidisciplinary Respiratory Medicine 2017 12:13
    Content type: Original research article Published on:

  3. Pulmonary drug delivery is currently the focus of accelerated research and development because of the potential to produce maximum therapeutic benefit to patients by directly targeting drug to the site of path...

    Authors: Federico Lavorini, Massimo Pistolesi and Omar S. Usmani
    Citation: Multidisciplinary Respiratory Medicine 2017 12:11
    Content type: Review Published on:

    The Erratum to this article has been published in Multidisciplinary Respiratory Medicine 2017 12:19

  4. To date, an important aspect that has still not been clarified is the assessment of OHS severity. The purpose of this retrospective study was to evaluate whether grading OHS severity according to PaCO2 values may...

    Authors: Mario Francesco Damiani, Vito Antonio Falcone, Pierluigi Carratù, Cristina Scoditti, Elioda Bega, Silvano Dragonieri, Alfredo Scoditti and Onofrio Resta
    Citation: Multidisciplinary Respiratory Medicine 2017 12:14
    Content type: Original research article Published on:

  5. Hypersensitivity pneumonitis (HP) is a common diffuse parenchymal lung disease in Egypt which can be difficult to recognize due to the dynamic symptoms & associated environmental factors.

    Authors: Dalia Abd El-Kareem, Yosri M. Akl, Gina A. Nakhla, Ali A. Elhindawi and Mahmoud A. Eltorky
    Citation: Multidisciplinary Respiratory Medicine 2017 12:10
    Content type: Research Article Published on:

  6. Severe and poorly controlled asthma still accounts for a great portion of the patients affected. Disease control and future risk management have been identified by international guidelines as the main goals in...

    Authors: Dejan Radovanovic, Pierachille Santus, Francesco Blasi and Marco Mantero
    Citation: Multidisciplinary Respiratory Medicine 2017 12:12
    Content type: Review Published on:

    The Erratum to this article has been published in Multidisciplinary Respiratory Medicine 2017 12:17

  7. Information and Communication Technologies applied to health care and advances in sensor and data transmission technology allowed tele-medicine based programs of care also for patients with respiratory diseases.

    Authors: Nicolino Ambrosino, Dewi Nurul Makhabah and Yusup Subagio Sutanto
    Citation: Multidisciplinary Respiratory Medicine 2017 12:9
    Content type: Review Published on:

  8. The intratracheal instillation of bleomycin in mice induces early damage to alveolar epithelial cells and development of inflammation followed by fibrotic tissue changes and represents the most widely used mod...

    Authors: Francesca Ruscitti, Francesca Ravanetti, Jeroen Essers, Yanto Ridwan, Sasha Belenkov, Wim Vos, Francisca Ferreira, Alex KleinJan, Paula van Heijningen, Cedric Van Holsbeke, Antonio Cacchioli, Gino Villetti and Franco Fabio Stellari
    Citation: Multidisciplinary Respiratory Medicine 2017 12:8
    Content type: Original research article Published on:

  10. Life-long regular use of drugs is necessary in chronic diseases like asthma and COPD. There are several methods to improve adherence including patient information and education; however, their effectiveness on...

    Authors: Gábor Tomisa, Alpár Horváth, Brigitta Dombai and Lilla Tamási
    Citation: Multidisciplinary Respiratory Medicine 2017 12:6
    Content type: Original research article Published on:

  11. Ventilator associated pneumonia currently in vogue seems to have some pitfalls as far as the nomenclature is concerned and thus it imparts an erroneous impression to the reader. As the driving force is in fact...

    Authors: Zahid Hussain Khan, Piero Ceriana and Claudio F. Donner
    Citation: Multidisciplinary Respiratory Medicine 2017 12:5
    Content type: Letter to the Editor Published on:

  14. It is estimated that about 60–70% of Cystic Fibrosis patients develop Pseudomonas aeruginosa chronic infection, with progressive loss of lung function, as well as increased antibiotic resistance and mortality.

    Authors: Marco Mantero, Andrea Gramegna, Giovanna Pizzamiglio, Alice D’Adda, Paolo Tarsia and Francesco Blasi
    Citation: Multidisciplinary Respiratory Medicine 2017 12:2
    Content type: Letter to the Editor Published on:

  15. Isolated cases of pulmonary arterial hypertension (PAH) with interferon α or β therapy have been reported, but no population-based estimates of the incidence of the disease after interferon exposure are availa...

    Authors: Ravikanth Papani, Alexander G. Duarte, Yu-li Lin, Yong-Fang Kuo and Gulshan Sharma
    Citation: Multidisciplinary Respiratory Medicine 2017 12:1
    Content type: Original research article Published on:

  16. The year 2015 marked the end of United Nations Millennium Development Goals which was aimed at halting and reversing worldwide tuberculosis (TB). The emergence of drug resistance is a major challenge for world...

    Authors: Waleed M. Sweileh, Adham S. AbuTaha, Ansam F. Sawalha, Suleiman Al-Khalil, Samah W. Al-Jabi and Sa’ed H. Zyoud
    Citation: Multidisciplinary Respiratory Medicine 2017 11:45
    Content type: Original research article Published on:

  17. Asthma is a common disease of the airways with a significant burden for the society and for patients’ quality of life. The Social Impact of Respiratory Integrated Outcomes (SIRIO) study estimated a mean cost o...

    Authors: Roberto W. Dal Negro, Chiara Distante, Luca Bonadiman, Paola Turco and Sergio Iannazzo
    Citation: Multidisciplinary Respiratory Medicine 2016 11:44
    Content type: Original research article Published on:

  18. We hypothesized that the use of oxygen supplementation during aerobic exercise induces less DNA damage than exercise alone.

    Authors: Andréa Lúcia Gonçalves da Silva, Thaís Evelyn Karnopp, Augusto Ferreira Weber, Cassia da Luz Goulart, Paloma de Borba Scheneiders, Dannuey Machado Cardoso, Lisiane Lisboa Carvalho, Joel Henrique Ellwanger, Lia Gonçalves Possuelo and Andréia Rosane de Moura Valim
    Citation: Multidisciplinary Respiratory Medicine 2016 11:43
    Content type: Original research article Published on:

  19. Health-care professionals have a responsibility to be attentive to patients’ adherence behavior but it could be difficult to identify poor adherence in the context of clinical practice. Assessment of personali...

    Authors: Malin Axelsson, Linda Ekerljung, Bo Lundbäck and Jan Lötvall
    Citation: Multidisciplinary Respiratory Medicine 2016 11:42
    Content type: Original research article Published on:

  20. Hemothorax after lung transplantation may result in increased post-operative morbidity and mortality. Risk factors for developing hemothorax and the outcomes of patients who develop hemothorax have not been we...

    Authors: Aria Hong, Christopher S. King, A. Whitney Walter Brown, Shahzad Ahmad, Oksana A. Shlobin, Sandeep Khandhar, Linda Bogar, Anthony Rongione and Steven D. Nathan
    Citation: Multidisciplinary Respiratory Medicine 2016 11:40
    Content type: Original research article Published on:

  21. This report is based on an independent study carried out by medical professionals of the Fondazione IRCCS Istituto Nazionale dei Tumori (National Cancer Institute) in Milan, Italy, and  aimed to assess the inc...

    Authors: Carla Valenti, Paolo Pozzi, Alessandra Busia, Roberto Mazza, Paolo Bossi, Cinzia De Marco, Ario Alberto Ruprecht, Alessandro Borgini and Roberto Boffi
    Citation: Multidisciplinary Respiratory Medicine 2016 11:41
    Content type: Original research article Published on:

  22. Coagulation abnormalities are involved in the pathogenesis of acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF). The administration of recombinant human soluble thrombomodulin (rhTM), which has bot...

    Authors: Sho Hayakawa, Yasuo Matsuzawa, Tamako Irie, Hagino Rikitake, Noriaki Okada and Yasuo Suzuki
    Citation: Multidisciplinary Respiratory Medicine 2016 11:38
    Content type: Original research article Published on:

  23. In the absence of randomisation, observational studies must take extra care to create treatment groups that are comparable in terms of key characteristics. Various matching methods exist which can create sound...

    Authors: David B. Price, Job F. M. van Boven, Lisa M. Law, Alessandra Cifra and R. Brett McQueen
    Citation: Multidisciplinary Respiratory Medicine 2016 11:39
    Content type: Letter to the Editor Published on:

  24. Despite major advances in the treatment of asthma and the development of several asthma guidelines, people still die of asthma currently. According to WHO estimates, approximately 250,000 people die prematurel...

    Authors: Gennaro D’Amato, Carolina Vitale, Antonio Molino, Anna Stanziola, Alessandro Sanduzzi, Alessandro Vatrella, Mauro Mormile, Maurizia Lanza, Giovanna Calabrese, Leonardo Antonicelli and Maria D’Amato
    Citation: Multidisciplinary Respiratory Medicine 2016 11:37
    Content type: Review Published on:

  25. The aim of this study is to evaluate the presence of neurocognitive dysfunctions, depression and anxiety and the effect of positive airway pressure (PAP) therapy on these alterations in Obesity Hypoventilation...

    Authors: Serap Argun Baris, Dilek Tuncel, Cigdem Ozerdem, Huseyin Kutlu, Tugba Onyilmaz, Ilknur Basyigit, Hasim Boyaci and Fusun Yildiz
    Citation: Multidisciplinary Respiratory Medicine 2016 11:35
    Content type: Original research article Published on:

  26. Visceral adipose tissue (VAT) was shown to be increased in patients with chronic obstructive pulmonary disease (COPD) compared to control subjects with comparable body mass index (BMI). Our aim was to determin...

    Authors: Francesca De Blasio, Erica P. A. Rutten, Emiel F. M. Wouters, Luca Scalfi, Francesco De Blasio, Marco A. Akkermans, Martijn A. Spruit and Frits M. E. Franssen
    Citation: Multidisciplinary Respiratory Medicine 2016 11:33
    Content type: Original research article Published on:

  27. Cough is one of the most common discomforts affecting general population, which can disrupt subjects’ quality of life due to its physical, social, and psychological effects. Aim of the study was to investigate...

    Authors: Roberto W. Dal Negro, Massimiliano Mazzolini, Paola Turco and Alessandro Zanasi
    Citation: Multidisciplinary Respiratory Medicine 2016 11:34
    Content type: Original research article Published on:

  29. Inhalation devices represent per sé critical factors because they can affect the therapeutic outcomes independently of the drug used. The role of patients’ usability and preference (PUP) for Dry Powder Inhalers (...

    Authors: Roberto W. Dal Negro and Massimiliano Povero
    Citation: Multidisciplinary Respiratory Medicine 2016 11:31
    Content type: Original research article Published on:

  30. An increasing number of inhalation devices are presently available in the market. They are differently characterized in terms of their handling and usability, both factors which may affect the outcomes of resp...

    Authors: Roberto W. Dal Negro and Massimiliano Povero
    Citation: Multidisciplinary Respiratory Medicine 2016 11:32
    Content type: Original research article Published on:

  32. Obesity is currently one of the major epidemics of this millennium and affects individuals throughout the world. It causes multiple systemic complications, some of which result in severe impairment of organs a...

    Authors: Thiago Thomaz Mafort, Rogério Rufino, Cláudia Henrique Costa and Agnaldo José Lopes
    Citation: Multidisciplinary Respiratory Medicine 2016 11:28
    Content type: Review Published on:

  33. The present study reports the results of a survey jointly carried out by three Italian respiratory scientific associations (AIMAR, AIPO, SIMeR) together with an important Federation of elderly patients (FederA...

    Authors: Nicola Ciancio, Claudio M. Sanguinetti, Franco Falcone, Claudio Taranto, Roberto Fasani, Fernando De Benedetto, Onofrio Resta, Fausto De Michele, Roberto Messina, Andrea Rossi, Stefano Nardini and Giuseppe Di Maria
    Citation: Multidisciplinary Respiratory Medicine 2016 11:26
    Content type: Original research article Published on:

  34. The air inhaled by people is abundantly populated with microorganisms which also are called bioaerosols. Bioaerosols is a colloidal suspension, formed by liquid droplets and particles of solid matter in the ai...

    Authors: Zemichael Gizaw, Mulat Gebrehiwot and Chalachew Yenew
    Citation: Multidisciplinary Respiratory Medicine 2016 11:24
    Content type: Original research article Published on:

  35. Sarcoidosis is a systemic granulomatous disease of unknown origin, characterized by the formation of granulomas without central necrosis. Each organ and tissue can be affected by the disease, but in most cases...

    Authors: Livio G. Moccia, Sabrina Castaldo, Emanuela Sirignano, Maddalena Napolitano, Enrica Barra and Alessandro Sanduzzi
    Citation: Multidisciplinary Respiratory Medicine 2016 11:27
    Content type: Case report Published on:

  36. Early identification and control of pathogenic bacteria are important in the treatment of pneumonia. Currently, two rapid antigen detection kits for pneumococcal pneumonia are available: one uses urine samples...

    Authors: Shoji Suzuki, Naoki Nishimura, Torahiko Jinta, Yasuhiko Yamano, Genta Ishikawa, Yutaka Tomishima, Noboru Uchiyama and Naohiko Chohnabayashi
    Citation: Multidisciplinary Respiratory Medicine 2016 11:25
    Content type: Original research article Published on:

  37. Acute cough is one of the most frequent symptoms prompting a visit to a health care provider, usually following a viral upper respiratory tract infection (URTI). The disproportionate use of antibiotics in chil...

    Authors: Alessandro Zanasi, Luigi Lanata, Federico Saibene, Giovanni Fontana, Peter V. Dicpinigaitis, Valentina Venier and Francesco De Blasio
    Citation: Multidisciplinary Respiratory Medicine 2016 11:29
    Content type: Original research article Published on:

  38. Dry powder inhalers (DPIs) are the most commonly used devices in asthma treatment in the Nordic countries. As new DPIs become available, patients are likely to be exposed to more than one type of device, with ...

    Authors: Birger Norderud Lærum, Gunilla Telg and Georgios Stratelis
    Citation: Multidisciplinary Respiratory Medicine 2016 11:21
    Content type: Original research article Published on:

  39. Asthma is a disease with high cost for the National Health Service. Two of the most recent LABA/ICS combinations for persistent bronchial asthma are Beclomethasone dipropionate/Formoterol (B/F) delivered via t...

    Authors: Roberto W. Dal Negro, Chiara Distante, Luca Bonadiman, Paola Turco and Sergio Iannazzo
    Citation: Multidisciplinary Respiratory Medicine 2016 11:20
    Content type: Original research article Published on:

  40. Hypoventilation produces or worsens respiratory acidosis in patients with hypercapnia due to acute exacerbations of chronic obstructive pulmonary disease (AECOPD). In these patients acid–base and hydroelectrol...

    Authors: Alfonso Schiavo, Maurizio Renis, Mario Polverino, Arcangelo Iannuzzi and Francesca Polverino
    Citation: Multidisciplinary Respiratory Medicine 2016 11:23
    Content type: Original research article Published on:

  41. The present study was initiated to investigate the effectiveness, safety and tolerability of complex homeopathic CalSuli-4-02 tablets on prevention of recurrent acute upper respiratory tract infections (URTIs)...

    Authors: Miek C. Jong, Stephen L. Buskin, Lydia Ilyenko, Irina Kholodova, Julia Burkart, Stephan Weber, Thomas Keller and Petra Klement
    Citation: Multidisciplinary Respiratory Medicine 2016 11:19
    Content type: Original research article Published on:

  42. There is limited information on prevalence of pulmonary tuberculosis (PTB) in patients with type-1-diabetes. We assessed the prevalence of PTB in patients with type-1-diabetes attending the outpatient-clinic i...

    Authors: Abilash Nair, Randeep Guleria, Devasenathipathy Kandasamy, Raju Sharma, Nikhil Tandon, Urvashi B. Singh and Ravinder Goswami
    Citation: Multidisciplinary Respiratory Medicine 2016 11:22
    Content type: Original research article Published on:

  43. The inflammatory diseases of the nose, rhino-pharynx and paranasal sinuses (allergic and non allergic rhinitis, NARES; rhinosinusitis with/without nasal polyposis, adenoidal hypertrophy with/without middle ear...

    Authors: Desiderio Passali, Maria Carla Spinosi, Anna Crisanti and Luisa Maria Bellussi
    Citation: Multidisciplinary Respiratory Medicine 2016 11:18
    Content type: Review Published on:

  44. Self-expandable metallic stents (SEMS) can be used to treat malignant obstructions and fistulas of the central airways. SEMS can be placed using different methods. Recently, a rigid bronchoscope has been used ...

    Authors: Cengiz Özdemir, Sinem Nedime Sökücü, Levent Karasulu, Seda Tural Önür and Levent Dalar
    Citation: Multidisciplinary Respiratory Medicine 2016 11:15
    Content type: Original research article Published on:

  45. Tracheobronchopathia Osteochondroplastica (TBPO) is an uncommon and benign condition characterized by osseous or metaplastic cartilaginous 1–3 mm nodules in the submucosa of the tracheo-bronchial tree. Posteri...

    Authors: Alessandro G. Fois, Antonella Arcadu, Luigi Santoru, Rocco Trisolini, Vincenzo Marras, Giorgio C. Ginesu, Sara Canu, Lorenzo Cordero, Gabriella Diana and Pietro Pirina
    Citation: Multidisciplinary Respiratory Medicine 2016 11:16
    Content type: Case report Published on:

  46. Chronic Obstructive Pulmonary Disease (COPD) is characterized by an excessive activation of the adaptive immune system and, in particular, uncontrolled expansion of the B-cell pool. One of the key promoters of...

    Authors: Francesca Polverino, Maria Laucho-Contreras, Joselyn Rojas Quintero, Miguel Divo, Victor Pinto-Plata, Lynette Sholl, Juan P. de-Torres, Bartolome R. Celli and Caroline A. Owen
    Citation: Multidisciplinary Respiratory Medicine 2016 11:17
    Content type: Original research article Published on:

  50. Chronic respiratory diseases represent a public health challenge in both industrialized and developing countries. Chronic respiratory symptoms are more prevalent in cement factories of developing countries, wh...

    Authors: Zemichael Gizaw, Bamlaku Yifred and Takele Tadesse
    Citation: Multidisciplinary Respiratory Medicine 2016 11:13
    Content type: Original research article Published on:

Multidisciplinary Respiratory Medicine

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