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  1. Content type: Original Research Article

    The effectiveness of a homeopathic syrup on cough has been demonstrated in an adult population in a previous double-blind randomized study. The present prospective observational study investigated children aff...

    Authors: Alessandro Zanasi, Salvatore Cazzato, Massimiliano Mazzolini, Carla Maria Sofia Ierna, Marianna Mastroroberto, Elena Nardi and Antonio Maria Morselli-Labate

    Citation: Multidisciplinary Respiratory Medicine 2015 10:25

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  2. Content type: Original research article

    Several comorbidities frequently affect COPD progression. Aim of the study was to assess the prevalence of main comorbidities by gender and disease severity in a cohort of COPD patients referring for the first ti...

    Authors: R. W. Dal Negro, L. Bonadiman and P. Turco

    Citation: Multidisciplinary Respiratory Medicine 2015 10:24

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  3. Content type: Original research article

    The Body Mass Index (BMI) is a widely used parameter to study obesity; however it does not assess the distribution of body adiposity. Ultrasonography is a reliable method of measuring subcutaneous (SAT), visce...

    Authors: Zied Rasslan, Roberto Stirbulov, Roberto Saad Junior, Sergio Tercio Curia, Carlos Alberto da Conceição Lima, Eduardo Araújo Perez, Ezequiel Fernandes Oliveira, Claudio Ferdinando Donner and Luis Vicente Franco Oliveira

    Citation: Multidisciplinary Respiratory Medicine 2015 10:23

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  4. Content type: Original research article

    Involvement of the small airways may be related to increased severity and increased demand for health care services and incurring in high costs, private or for the healthcare system. The hyperinflation consequ...

    Authors: J.F. Castelluccio, R. Stirbulov, E.A. Perez, J.C.M. Oliveira, C.F. Donner, L.V.F. Oliveira and Z. Rasslan

    Citation: Multidisciplinary Respiratory Medicine 2015 10:22

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  5. Content type: Original research article

    Recent studies investigating the health effects of air pollution have proven an existing impact around and below international air quality guidelines and standards. These studies were based on accessible data ...

    Authors: Myriam Mrad Nakhlé, Wehbeh Farah, Nelly Ziade, Maher Abboud, Marie-Louise Coussa-Koniski and Isabella Annesi-Maesano

    Citation: Multidisciplinary Respiratory Medicine 2015 10:21

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  6. Content type: Original research article

    Asthma is a serious chronic inflammatory disease affecting 300 million people worldwide. This aim of this study to investigate the anti-inflammatory and anti-asthmatic effects of Laminaria japonica extract in the...

    Authors: Rongjun Lin, Xiaomei Liu, Yan Meng, Mei Xu and Jianping Guo

    Citation: Multidisciplinary Respiratory Medicine 2015 10:20

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  7. Content type: Original Research Article

    Cough is one of the most common symptoms for which patients seek medical attention from primary care physicians and lung specialists. About 40% of the population at any one time report cough.

    Authors: Alessandro Zanasi, Luigi Lanata, Giovanni Fontana, Federico Saibene, Peter Dicpinigaitis and Francesco De Blasio

    Citation: Multidisciplinary Respiratory Medicine 2015 10:19

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  8. Content type: Review

    Kartagener Syndrome (KS) is a rare autosomal recessive genetic disorder, resulting in a group of clinical manifestations, including bronchiectasis, chronic pansinusitis and situs inversus.

    Authors: Nicola Ciancio, Maria Margherita de Santi, Raffaele Campisi, Laura Amato, Giuseppina Di Martino and Giuseppe Di Maria

    Citation: Multidisciplinary Respiratory Medicine 2015 10:18

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  9. Content type: Original research article

    Chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory condition which can lead to comorbidities of variable severity, cognitive dysfunction included. The role of supplemental oxygen in prev...

    Authors: Roberto W Dal Negro, Luca Bonadiman, Fernanda P Bricolo, Silvia Tognella and Paola Turco

    Citation: Multidisciplinary Respiratory Medicine 2015 10:17

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  10. Content type: Original research article

    Horses commonly suffer from chronic respiratory disease and are also used in large animal models of spontaneous or induced airway inflammation. The anti-inflammatory properties of curcumin are largely describe...

    Authors: Charlotte Sandersen, Dorothee Bienzle, Simona Cerri, Thierry Franck, Sandrine Derochette, Philippe Neven, Ange Mouytis-Mickalad and Didier Serteyn

    Citation: Multidisciplinary Respiratory Medicine 2015 10:16

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  11. Content type: Case report

    We herein report a case of invasive candidiasis presenting rare findings on chest computed tomography (CT). The chest CT scan showed multiple small cavitary lesions and nodules with surrounding ground-glass op...

    Authors: Yuichiro Yasuda, Kazunori Tobino, Mina Asaji, Yoshikazu Yamaji and Kosuke Tsuruno

    Citation: Multidisciplinary Respiratory Medicine 2015 10:11

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  12. Content type: Case report

    Bronchial thermoplasty (BT) is a new therapeutic option for severe refractory asthma not controlled despite high dose inhaled corticosteroids plus long-acting bronchodilators and omalizumab in selected cases. ...

    Authors: Nicola Facciolongo, Francesco Menzella, Mirco Lusuardi, Roberto Piro, Carla Galeone, Claudia Castagnetti, Alberto Cavazza, Cristiano Carbonelli, Luigi Zucchi and Pier Paolo Salsi

    Citation: Multidisciplinary Respiratory Medicine 2015 10:9

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  13. Content type: Original research article

    Data for the U.S adult population from the National Health and Nutrition Examination Survey (NHANES) were used to evaluate risk factors for a restrictive pattern on spirometry and estimate the change in its pr...

    Authors: Laura Kurth and Eva Hnizdo

    Citation: Multidisciplinary Respiratory Medicine 2015 10:7

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  14. Content type: State of the art

    Withholding and withdrawing a treatment already established are two forms of limitation of the therapeutic effort (LTE). The question of undergoing or not undergoing lifesaving medical treatments is not restri...

    Authors: Patrizia Borsellino

    Citation: Multidisciplinary Respiratory Medicine 2015 10:5

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  15. Content type: Reviewer acknowledgement

    The editors of Multidisciplinary Respiratory Medicine would like to thank all of our reviewers who have contributed to the journal in Volume 9 (2014).

    Authors: Fernando De Benedetto, Claudio F Donner and Claudio M Sanguinetti

    Citation: Multidisciplinary Respiratory Medicine 2015 10:2

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  16. Content type: Original research article

    Chronic Obstructive Pulmonary Disease (COPD) is characterized by respiratory and extrarespiratory components referring both to systemic complications of COPD, like skeletal muscle myopathy, weight loss and oth...

    Authors: Giorgio Fumagalli, Fabrizio Fabiani, Silvia Forte, Massimiliano Napolitano, Giovanni Balzano, Matteo Bonini, Giuseppe De Simone, Salvatore Fuschillo, Antonella Pentassuglia, Franco Pasqua, Pietro Alimonti, Stefano Carlone and Claudio M Sanguinetti

    Citation: Multidisciplinary Respiratory Medicine 2015 10:4

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  17. Content type: Original research article

    The adequate control of asthma includes the absence of nocturnal symptoms, minimal use of medication, normal or nearly normal lung function and no limitations to physical activity. The choice of a more sedenta...

    Authors: Elisangela Ramos, Luis Vicente Franco de Oliveira, Audrey Borghi Silva, Ivan Peres Costa, João Carlos Ferrari Corrêa, Dirceu Costa, Vera Lucia Alves, Claudio F Donner, Roberto Stirbulov, Ross Arena and Luciana Malosa Sampaio

    Citation: Multidisciplinary Respiratory Medicine 2015 10:3

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  18. Content type: Review

    Patients with severe asthma or COPD have often a suboptimal symptom control due to inadequate treatment. A better understanding of pathogenetic mechanisms, phenotypes, endotypes and the new technologies availa...

    Authors: Francesco Menzella, Mirco Lusuardi, Carla Galeone and Luigi Zucchi

    Citation: Multidisciplinary Respiratory Medicine 2015 10:1

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  19. Content type: Original research article

    Chronic Obstructive Pulmonary Disease (COPD) ranks third as cause of mortality and disability-adjusted life years (DALY) worldwide and also in Italy it imposes a huge health, social and economic load. Early sy...

    Authors: Claudio M Sanguinetti, Nicolino Ambrosino, Filippo Andò, Fernando De Benedetto, Claudio F Donner, Stefano Nardini, Mario Polverino, Roberto Torchio, Guido Vagheggini and Alberto Visconti

    Citation: Multidisciplinary Respiratory Medicine 2014 9:65

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  20. Content type: Review

    Chronic obstructive pulmonary disease (COPD) is a widespread respiratory disorder, usually characterized by progressive and poorly reversible airflow limitation. Inhaled long-acting bronchodilators, namely LAB...

    Authors: Girolamo Pelaia, Rosario Maselli and Luca Gallelli

    Citation: Multidisciplinary Respiratory Medicine 2014 9:64

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  21. Content type: Review

    This article deals with the prevalence and the possible reasons of COPD underestimation in the population and gives suggestions on how to overcome the obstacles and make the correct diagnosis in order to provi...

    Authors: Stefano Carlone, Bruno Balbi, Michela Bezzi, Marco Brunori, Stefano Calabro, Maria Pia Foschino Barbaro, Claudio Micheletto, Salvatore Privitera, Roberto Torchio, Pietro Schino and Andrea Vianello

    Citation: Multidisciplinary Respiratory Medicine 2014 9:63

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  22. Content type: Case report

    Chemical pleurodesis is widely recommended in the treatment of pulmonary air leak of different etiologies as well as malignant pleural effusions and chylothorax. Conventional chemical pleurodesis using erythro...

    Authors: Suk Ju Cho, Su Wan Kim and Jee Won Chang

    Citation: Multidisciplinary Respiratory Medicine 2014 9:61

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  23. Content type: Review

    Adherence to medical therapies is a growing issue, so much so that the World Health Organization defined it as “a new pharmacological problem”. The main factors affecting compliance are: frequency of administr...

    Authors: Alessandro Sanduzzi, Piero Balbo, Piero Candoli, Giousuè A Catapano, Paola Contini, Alessio Mattei, Giovanni Puglisi, Luigi Santoiemma and Anna A Stanziola

    Citation: Multidisciplinary Respiratory Medicine 2014 9:60

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  24. Content type: Original research article

    Acute pneumonia is a serious problem in the elderly and various risk factors have already been reported, but the involvement of QTc interval prolongation remains uncertain. The aim of this study was to elucida...

    Authors: Yasuyuki Taooka, Gen Takezawa, Miki Ohe, Akihisa Sutani and Takeshi Isobe

    Citation: Multidisciplinary Respiratory Medicine 2014 9:59

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  25. Content type: Original research article

    (Buccalin ®) is a Bacterial Lysates (BL) that belongs to a family of immune-stimulators, developed more than 30 years ago and it still has a role in the prophylaxis of Recurrent Respiratory Tract Infections (R...

    Authors: Stefano Carlone, Michele Minenna, Paride Morlino, Luigi Mosca, Franco Pasqua, Riccardo Pela, Pietro Schino, Alberto Tubaldi, Emmanuele Tupputi and Fernando De Benedetto

    Citation: Multidisciplinary Respiratory Medicine 2014 9:58

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  26. Content type: Original research article

    Clinical trials applying iota-carrageenan nasal spray have previously shown to reduce duration of virus-confirmed common cold. The present study pooled data of two similar clinical trials to provide further ev...

    Authors: Martin Koenighofer, Thomas Lion, Angelika Bodenteich, Eva Prieschl-Grassauer, Andreas Grassauer, Hermann Unger, Christian A Mueller and Tamás Fazekas

    Citation: Multidisciplinary Respiratory Medicine 2014 9:57

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  27. Content type: Review

    This review examines some of the issues encountered in the use of sedation in patients receiving respiratory support from non-invasive ventilation (NIV). This is an area of critical and intensive care medicine...

    Authors: Dan Longrois, Giorgio Conti, Jean Mantz, Andreas Faltlhauser, Riku Aantaa and Peter Tonner

    Citation: Multidisciplinary Respiratory Medicine 2014 9:56

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  28. Content type: Case report

    Veno-arterial extracorporeal membrane oxygenation (ECMO) through the femoral vein and artery may cause differential hypoxia, i.e., lower PaO2 in the upper body than in the lower body, because of normal cardiac ou...

    Authors: Joon Hyouk Choi, Su Wan Kim, Young Uck Kim, Song-Yi Kim, Ki-Seok Kim, Seung-Jae Joo and Jung Seok Lee

    Citation: Multidisciplinary Respiratory Medicine 2014 9:55

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  29. Content type: Original research article

    Tracheal occlusion (TO) stimulates lung growth in fetuses affected with congenital diaphragmatic hernia (CDH) although the processes involved in lung maturation still remain unknown. The objective of this stud...

    Authors: Gloria Pelizzo, Maurizio Ballico, Maria Chiara Mimmi, José Louis Peirò, Mario Marotta, Costanzo Federico, Erika Andreatta, Ghassan Nakib, Maurilio Sampaolesi, Elisa Zambaiti and Valeria Calcaterra

    Citation: Multidisciplinary Respiratory Medicine 2014 9:54

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  30. Content type: Original research article

    The management of patients with complex forms of bronchial asthma and COPD is not usually addressed in the major international guidelines and management documents which exclusively address pure forms. AIMAR th...

    Authors: Claudio F Donner and Alberto Visconti

    Citation: Multidisciplinary Respiratory Medicine 2014 9:52

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  31. Content type: Original research article

    Data on exercise pulmonary hemodynamics in healthy people and patients with pulmonary hypertension (PH) are rare. We analyzed exercise right heart catheterization (RHC) data in a symptomatic collective referre...

    Authors: Stephan Keusch, Anina Bucher, Séverine Müller-Mottet, Elisabeth Hasler, Marco Maggiorini, Rudolf Speich and Silvia Ulrich

    Citation: Multidisciplinary Respiratory Medicine 2014 9:51

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  32. Content type: Review

    The most recent guidelines define COPD in a multidimensional way, nevertheless the diagnosis is still linked to the limitation of airflow, usually measured by the reduction in the FEV1/FVC ratio below 70%. Howeve...

    Authors: Stefano Nardini, Gianna Camiciottoli, Salvatore Locicero, Rosario Maselli, Franco Pasqua, Giovanni Passalacqua, Riccardo Pela, Alberto Pesci, Alfredo Sebastiani and Alessandro Vatrella

    Citation: Multidisciplinary Respiratory Medicine 2014 9:50

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  33. Content type: Original research article

    The protein neutrophil gelatinase-associated lipocalin (NGAL) is a mediator synthesized and released by neutrophils. Its physiological function is as yet unclear. Levels in blood increase in several inflammato...

    Authors: Aziz Gümüs, Sevket Ozkaya, Songul Ozyurt, Halit Cınarka, Aynur Kirbas, Unal Sahin and Ferah Ece

    Citation: Multidisciplinary Respiratory Medicine 2014 9:49

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  34. Content type: Original research article

    The pathophysiological changes of COPD tend to worsen with progression, triggering limiting symptoms and implying the decrease in the activities of daily living and quality of life. The COPD Assessment Test (C...

    Authors: Cíntia Becker, Janaína Schäfer, Lisiane L Carvalho, Isabel P Vitiello and Andréa LG da Silva

    Citation: Multidisciplinary Respiratory Medicine 2014 9:47

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  35. Content type: Review

    Respiratory diseases in Italy already now represent an emergency (they are the 3rd ranking cause of death in the world, and the 2nd if Lung cancer is included). In countries similar to our own, they result as the...

    Authors: Stefano Nardini, Isabella Annesi-Maesano, Mario Del Donno, Maurizio Delucchi, Germano Bettoncelli, Vincenzo Lamberti, Carlo Patera, Mario Polverino, Antonio Russo, Carlo Santoriello and Patrizio Soverina

    Citation: Multidisciplinary Respiratory Medicine 2014 9:46

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  36. Content type: Review

    Delivery of sedation in anticipation of weaning of adult patients from prolonged mechanical ventilation is an arena of critical care medicine where opinion-based practice is currently hard to avoid because rob...

    Authors: Giorgio Conti, Jean Mantz, Dan Longrois and Peter Tonner

    Citation: Multidisciplinary Respiratory Medicine 2014 9:45

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  37. Content type: Original research article

    The aim of this study was to evaluate the level of reactive oxygen metabolites (ROMs) after chemotherapy in patients with non-small cell lung cancer (NSCLC) and its association with response to treatment.

    Authors: Toru Wakabayashi, Tatsuo Kawashima and Yasuo Matsuzawa

    Citation: Multidisciplinary Respiratory Medicine 2014 9:44

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  38. Content type: Original research article

    The increasing prevalence of obesity in both developed and developing countries is one of the most serious public health problems and has led to a global epidemic. Obesity is one of the greatest risk factors o...

    Authors: Isabella C Aguiar, Wilson R Freitas Jr, Israel R Santos, Nadua Apostolico, Sergio R Nacif, Jéssica Julioti Urbano, Nina Teixeira Fonsêca, Fabio Rodrigues Thuler, Elias Jirjoss Ilias, Paulo Kassab, Fernando SS LeitãoFilho, Rafael M Laurino Neto, Carlos A Malheiros, Giuseppe Insalaco, Claudio F Donner and Luis VF Oliveira

    Citation: Multidisciplinary Respiratory Medicine 2014 9:43

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  39. Content type: Technical note

    The main function of the mucociliary system is the removal of particles or substances that are potentially harmful to the respiratory tract. The tuning fork therapeutic for the purpose of bronchial hygiene has...

    Authors: José Roberto de Alcântara, Roberta Munhoz Manzano, Maicon Gabriel Gonçalves, Rodrigo Leonel dos Santos, Daniel Donaire Albino, Nadua Apostólico, Nina Teixeira Fonseca, Jéssica Julioti Urbano, Célio Guilherme Lombardi Daibem, Claudio F Donner, Camila Gimenes, Alexandre Ricardo Pepe Ambrozin and Luis Vicente Franco de Oliveira

    Citation: Multidisciplinary Respiratory Medicine 2014 9:41

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