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  1. Content type: Case report

    Bronchial thermoplasty (BT) is a new therapeutic option for severe refractory asthma not controlled despite high dose inhaled corticosteroids plus long-acting bronchodilators and omalizumab in selected cases. ...

    Authors: Nicola Facciolongo, Francesco Menzella, Mirco Lusuardi, Roberto Piro, Carla Galeone, Claudia Castagnetti, Alberto Cavazza, Cristiano Carbonelli, Luigi Zucchi and Pier Paolo Salsi

    Citation: Multidisciplinary Respiratory Medicine 2015 10:9

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  2. Content type: Original research article

    Data for the U.S adult population from the National Health and Nutrition Examination Survey (NHANES) were used to evaluate risk factors for a restrictive pattern on spirometry and estimate the change in its pr...

    Authors: Laura Kurth and Eva Hnizdo

    Citation: Multidisciplinary Respiratory Medicine 2015 10:7

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  3. Content type: State of the art

    Withholding and withdrawing a treatment already established are two forms of limitation of the therapeutic effort (LTE). The question of undergoing or not undergoing lifesaving medical treatments is not restri...

    Authors: Patrizia Borsellino

    Citation: Multidisciplinary Respiratory Medicine 2015 10:5

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  4. Content type: Reviewer acknowledgement

    The editors of Multidisciplinary Respiratory Medicine would like to thank all of our reviewers who have contributed to the journal in Volume 9 (2014).

    Authors: Fernando De Benedetto, Claudio F Donner and Claudio M Sanguinetti

    Citation: Multidisciplinary Respiratory Medicine 2015 10:2

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  5. Content type: Original research article

    Chronic Obstructive Pulmonary Disease (COPD) is characterized by respiratory and extrarespiratory components referring both to systemic complications of COPD, like skeletal muscle myopathy, weight loss and oth...

    Authors: Giorgio Fumagalli, Fabrizio Fabiani, Silvia Forte, Massimiliano Napolitano, Giovanni Balzano, Matteo Bonini, Giuseppe De Simone, Salvatore Fuschillo, Antonella Pentassuglia, Franco Pasqua, Pietro Alimonti, Stefano Carlone and Claudio M Sanguinetti

    Citation: Multidisciplinary Respiratory Medicine 2015 10:4

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  6. Content type: Original research article

    The adequate control of asthma includes the absence of nocturnal symptoms, minimal use of medication, normal or nearly normal lung function and no limitations to physical activity. The choice of a more sedenta...

    Authors: Elisangela Ramos, Luis Vicente Franco de Oliveira, Audrey Borghi Silva, Ivan Peres Costa, João Carlos Ferrari Corrêa, Dirceu Costa, Vera Lucia Alves, Claudio F Donner, Roberto Stirbulov, Ross Arena and Luciana Malosa Sampaio

    Citation: Multidisciplinary Respiratory Medicine 2015 10:3

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  7. Content type: Review

    Patients with severe asthma or COPD have often a suboptimal symptom control due to inadequate treatment. A better understanding of pathogenetic mechanisms, phenotypes, endotypes and the new technologies availa...

    Authors: Francesco Menzella, Mirco Lusuardi, Carla Galeone and Luigi Zucchi

    Citation: Multidisciplinary Respiratory Medicine 2015 10:1

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  8. Content type: Original research article

    Chronic Obstructive Pulmonary Disease (COPD) ranks third as cause of mortality and disability-adjusted life years (DALY) worldwide and also in Italy it imposes a huge health, social and economic load. Early sy...

    Authors: Claudio M Sanguinetti, Nicolino Ambrosino, Filippo Andò, Fernando De Benedetto, Claudio F Donner, Stefano Nardini, Mario Polverino, Roberto Torchio, Guido Vagheggini and Alberto Visconti

    Citation: Multidisciplinary Respiratory Medicine 2014 9:65

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  9. Content type: Review

    Chronic obstructive pulmonary disease (COPD) is a widespread respiratory disorder, usually characterized by progressive and poorly reversible airflow limitation. Inhaled long-acting bronchodilators, namely LAB...

    Authors: Girolamo Pelaia, Rosario Maselli and Luca Gallelli

    Citation: Multidisciplinary Respiratory Medicine 2014 9:64

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  10. Content type: Review

    This article deals with the prevalence and the possible reasons of COPD underestimation in the population and gives suggestions on how to overcome the obstacles and make the correct diagnosis in order to provi...

    Authors: Stefano Carlone, Bruno Balbi, Michela Bezzi, Marco Brunori, Stefano Calabro, Maria Pia Foschino Barbaro, Claudio Micheletto, Salvatore Privitera, Roberto Torchio, Pietro Schino and Andrea Vianello

    Citation: Multidisciplinary Respiratory Medicine 2014 9:63

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  11. Content type: Case report

    Chemical pleurodesis is widely recommended in the treatment of pulmonary air leak of different etiologies as well as malignant pleural effusions and chylothorax. Conventional chemical pleurodesis using erythro...

    Authors: Suk Ju Cho, Su Wan Kim and Jee Won Chang

    Citation: Multidisciplinary Respiratory Medicine 2014 9:61

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  12. Content type: Review

    Adherence to medical therapies is a growing issue, so much so that the World Health Organization defined it as “a new pharmacological problem”. The main factors affecting compliance are: frequency of administr...

    Authors: Alessandro Sanduzzi, Piero Balbo, Piero Candoli, Giousuè A Catapano, Paola Contini, Alessio Mattei, Giovanni Puglisi, Luigi Santoiemma and Anna A Stanziola

    Citation: Multidisciplinary Respiratory Medicine 2014 9:60

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  13. Content type: Original research article

    Acute pneumonia is a serious problem in the elderly and various risk factors have already been reported, but the involvement of QTc interval prolongation remains uncertain. The aim of this study was to elucida...

    Authors: Yasuyuki Taooka, Gen Takezawa, Miki Ohe, Akihisa Sutani and Takeshi Isobe

    Citation: Multidisciplinary Respiratory Medicine 2014 9:59

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  14. Content type: Original research article

    (Buccalin ®) is a Bacterial Lysates (BL) that belongs to a family of immune-stimulators, developed more than 30 years ago and it still has a role in the prophylaxis of Recurrent Respiratory Tract Infections (R...

    Authors: Stefano Carlone, Michele Minenna, Paride Morlino, Luigi Mosca, Franco Pasqua, Riccardo Pela, Pietro Schino, Alberto Tubaldi, Emmanuele Tupputi and Fernando De Benedetto

    Citation: Multidisciplinary Respiratory Medicine 2014 9:58

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  15. Content type: Original research article

    Clinical trials applying iota-carrageenan nasal spray have previously shown to reduce duration of virus-confirmed common cold. The present study pooled data of two similar clinical trials to provide further ev...

    Authors: Martin Koenighofer, Thomas Lion, Angelika Bodenteich, Eva Prieschl-Grassauer, Andreas Grassauer, Hermann Unger, Christian A Mueller and Tamás Fazekas

    Citation: Multidisciplinary Respiratory Medicine 2014 9:57

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  16. Content type: Review

    This review examines some of the issues encountered in the use of sedation in patients receiving respiratory support from non-invasive ventilation (NIV). This is an area of critical and intensive care medicine...

    Authors: Dan Longrois, Giorgio Conti, Jean Mantz, Andreas Faltlhauser, Riku Aantaa and Peter Tonner

    Citation: Multidisciplinary Respiratory Medicine 2014 9:56

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  17. Content type: Original research article

    Tracheal occlusion (TO) stimulates lung growth in fetuses affected with congenital diaphragmatic hernia (CDH) although the processes involved in lung maturation still remain unknown. The objective of this stud...

    Authors: Gloria Pelizzo, Maurizio Ballico, Maria Chiara Mimmi, José Louis Peirò, Mario Marotta, Costanzo Federico, Erika Andreatta, Ghassan Nakib, Maurilio Sampaolesi, Elisa Zambaiti and Valeria Calcaterra

    Citation: Multidisciplinary Respiratory Medicine 2014 9:54

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  18. Content type: Case report

    Veno-arterial extracorporeal membrane oxygenation (ECMO) through the femoral vein and artery may cause differential hypoxia, i.e., lower PaO2 in the upper body than in the lower body, because of normal cardiac ou...

    Authors: Joon Hyouk Choi, Su Wan Kim, Young Uck Kim, Song-Yi Kim, Ki-Seok Kim, Seung-Jae Joo and Jung Seok Lee

    Citation: Multidisciplinary Respiratory Medicine 2014 9:55

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  19. Content type: Original research article

    The management of patients with complex forms of bronchial asthma and COPD is not usually addressed in the major international guidelines and management documents which exclusively address pure forms. AIMAR th...

    Authors: Claudio F Donner and Alberto Visconti

    Citation: Multidisciplinary Respiratory Medicine 2014 9:52

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  20. Content type: Review

    The most recent guidelines define COPD in a multidimensional way, nevertheless the diagnosis is still linked to the limitation of airflow, usually measured by the reduction in the FEV1/FVC ratio below 70%. Howeve...

    Authors: Stefano Nardini, Gianna Camiciottoli, Salvatore Locicero, Rosario Maselli, Franco Pasqua, Giovanni Passalacqua, Riccardo Pela, Alberto Pesci, Alfredo Sebastiani and Alessandro Vatrella

    Citation: Multidisciplinary Respiratory Medicine 2014 9:50

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  21. Content type: Original research article

    Data on exercise pulmonary hemodynamics in healthy people and patients with pulmonary hypertension (PH) are rare. We analyzed exercise right heart catheterization (RHC) data in a symptomatic collective referre...

    Authors: Stephan Keusch, Anina Bucher, Séverine Müller-Mottet, Elisabeth Hasler, Marco Maggiorini, Rudolf Speich and Silvia Ulrich

    Citation: Multidisciplinary Respiratory Medicine 2014 9:51

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  22. Content type: Original research article

    The protein neutrophil gelatinase-associated lipocalin (NGAL) is a mediator synthesized and released by neutrophils. Its physiological function is as yet unclear. Levels in blood increase in several inflammato...

    Authors: Aziz Gümüs, Sevket Ozkaya, Songul Ozyurt, Halit Cınarka, Aynur Kirbas, Unal Sahin and Ferah Ece

    Citation: Multidisciplinary Respiratory Medicine 2014 9:49

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  23. Content type: Original research article

    The pathophysiological changes of COPD tend to worsen with progression, triggering limiting symptoms and implying the decrease in the activities of daily living and quality of life. The COPD Assessment Test (C...

    Authors: Cíntia Becker, Janaína Schäfer, Lisiane L Carvalho, Isabel P Vitiello and Andréa LG da Silva

    Citation: Multidisciplinary Respiratory Medicine 2014 9:47

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  24. Content type: Review

    Respiratory diseases in Italy already now represent an emergency (they are the 3rd ranking cause of death in the world, and the 2nd if Lung cancer is included). In countries similar to our own, they result as the...

    Authors: Stefano Nardini, Isabella Annesi-Maesano, Mario Del Donno, Maurizio Delucchi, Germano Bettoncelli, Vincenzo Lamberti, Carlo Patera, Mario Polverino, Antonio Russo, Carlo Santoriello and Patrizio Soverina

    Citation: Multidisciplinary Respiratory Medicine 2014 9:46

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  25. Content type: Review

    Delivery of sedation in anticipation of weaning of adult patients from prolonged mechanical ventilation is an arena of critical care medicine where opinion-based practice is currently hard to avoid because rob...

    Authors: Giorgio Conti, Jean Mantz, Dan Longrois and Peter Tonner

    Citation: Multidisciplinary Respiratory Medicine 2014 9:45

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  26. Content type: Original research article

    The aim of this study was to evaluate the level of reactive oxygen metabolites (ROMs) after chemotherapy in patients with non-small cell lung cancer (NSCLC) and its association with response to treatment.

    Authors: Toru Wakabayashi, Tatsuo Kawashima and Yasuo Matsuzawa

    Citation: Multidisciplinary Respiratory Medicine 2014 9:44

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  27. Content type: Original research article

    The increasing prevalence of obesity in both developed and developing countries is one of the most serious public health problems and has led to a global epidemic. Obesity is one of the greatest risk factors o...

    Authors: Isabella C Aguiar, Wilson R Freitas Jr, Israel R Santos, Nadua Apostolico, Sergio R Nacif, Jéssica Julioti Urbano, Nina Teixeira Fonsêca, Fabio Rodrigues Thuler, Elias Jirjoss Ilias, Paulo Kassab, Fernando SS LeitãoFilho, Rafael M Laurino Neto, Carlos A Malheiros, Giuseppe Insalaco, Claudio F Donner and Luis VF Oliveira

    Citation: Multidisciplinary Respiratory Medicine 2014 9:43

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  28. Content type: Technical note

    The main function of the mucociliary system is the removal of particles or substances that are potentially harmful to the respiratory tract. The tuning fork therapeutic for the purpose of bronchial hygiene has...

    Authors: José Roberto de Alcântara, Roberta Munhoz Manzano, Maicon Gabriel Gonçalves, Rodrigo Leonel dos Santos, Daniel Donaire Albino, Nadua Apostólico, Nina Teixeira Fonseca, Jéssica Julioti Urbano, Célio Guilherme Lombardi Daibem, Claudio F Donner, Camila Gimenes, Alexandre Ricardo Pepe Ambrozin and Luis Vicente Franco de Oliveira

    Citation: Multidisciplinary Respiratory Medicine 2014 9:41

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  29. Content type: Original research article

    Non communicable chronic diseases (including respiratory ones) are the leading cause of death and disability. To cope with them we need to redesign the health system, improving primary prevention, screening, a...

    Authors: Stefano Nardini, Gaetano Cicchitto, Fernando De Benedetto, Claudio F Donner, Mario Polverino, Claudio M Sanguinetti and Alberto Visconti

    Citation: Multidisciplinary Respiratory Medicine 2014 9:40

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  30. Content type: State of the art

    A general rationale is presented for withholding and withdrawing medical treatment in end-of-life situations, and an argument is offered for the moral irrelevance of the distinction, both in the context of pha...

    Authors: Massimo Reichlin

    Citation: Multidisciplinary Respiratory Medicine 2014 9:39

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  31. Content type: Original research article

    Chronic respiratory diseases, like bronchial asthma and chronic obstructive pulmonary disease (COPD), are a worldwide health problem. Quantitative and qualitative assessment of asthma and COPD-related research...

    Authors: Waleed M Sweileh, Samah W Al-Jabi, Sa’ed H Zyoud and Ansam F Sawalha

    Citation: Multidisciplinary Respiratory Medicine 2014 9:38

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  32. Content type: Original research article

    Resistance training of peripheral muscles has been recommended in order to increase muscle strength in patients with Chronic Obstructive Pulmonary Disease (COPD). However, whether peripheral muscle strength is...

    Authors: Anne-Kathrin Rausch-Osthoff, Malcolm Kohler, Noriane A Sievi, Christian F Clarenbach and Arnoldus JR van Gestel

    Citation: Multidisciplinary Respiratory Medicine 2014 9:37

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  33. Content type: Review

    Safe removal of tracheal cannula is a major goal in the rehabilitation of tracheostomised patients to achieve progressive independence from mechanical support and reduce the risk of respiratory complications. ...

    Authors: Giancarlo Garuti, Cristina Reverberi, Angelo Briganti, Monica Massobrio, Francesco Lombardi and Mirco Lusuardi

    Citation: Multidisciplinary Respiratory Medicine 2014 9:36

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  34. Content type: Original research article

    Symptoms of COPD are frequently disregarded by patients and also by general practitioners (GPs) in early stages of the disease, that consequently is diagnosed when already at an advanced grade of severity. Und...

    Authors: Claudio M Sanguinetti, Fernando De Benedetto, Claudio F Donner, Stefano Nardini and Alberto Visconti

    Citation: Multidisciplinary Respiratory Medicine 2014 9:35

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  35. Content type: Original research article

    The aim of this study was to analyze the influence of active and passive smoking on cardiorespiratory responses in asymptomatic adults during a sub-maximal-exertion incremental test.

    Authors: Andresa Thier de Borba, Renan Trevisan Jost, Ricardo Gass, Fúlvio Borges Nedel, Dannuey Machado Cardoso, Hildegard Hedwig Pohl, Miriam Beatris Reckziegel, Valeriano Antonio Corbellini and Dulciane Nunes Paiva

    Citation: Multidisciplinary Respiratory Medicine 2014 9:34

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  36. Content type: Short report

    This study aimed to evaluate the clinical value of chest ultrasound (US) in the detection, diagnosis and follow-up of pathologic processes of both peripheral lung parenchyma and pleural space in pregnant women.

    Authors: Riccardo Inchingolo, Andrea Smargiassi, Flaminio Mormile, Roberta Marra, Sara De Carolis, Antonio Lanzone, Salvatore Valente and Giuseppe M Corbo

    Citation: Multidisciplinary Respiratory Medicine 2014 9:32

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  37. Content type: Case report

    Idiopathic pulmonary fibrosis (IPF) is defined as a chronic fibrosing interstitial disease of unknown cause, limited to the lungs, and associated with the histopathologic and/or radiologic pattern of usual int...

    Authors: Gaetano Cicchitto, Valentina Musella, Maria Acitorio, Nicola Capuano, Giuseppe Fiorenzano, Caroline A Owen, Mario Polverino and Francesca Polverino

    Citation: Multidisciplinary Respiratory Medicine 2014 9:31

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  38. Content type: Review

    The purpose of asthma management is to achieve a total asthma control that involves current control and future risk. It has proven efficacy in reducing asthma exacerbations, but the effect size of zafirlukast ...

    Authors: Chao Feng Chen, Yan Lv, Hong Ping Zhang and Gang Wang

    Citation: Multidisciplinary Respiratory Medicine 2014 9:30

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  39. Content type: Original research article

    Aquaporins AQP1 and AQP5 are highly expressed in the lung. Recent studies have shown that the expression of these proteins may be mechanistically involved in the airway inflammation and in the pathogenesis of ...

    Authors: Carmen Calero, Jose Luis López-Campos, Lourdes Gómez Izquierdo, Rocío Sánchez-Silva, Jose Luis López-Villalobos, Francisco J Sáenz-Coronilla, Elena Arellano-Orden, Ana Montes-Worboys and Miriam Echevarría

    Citation: Multidisciplinary Respiratory Medicine 2014 9:29

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  40. Content type: Short report

    Cardiovascular and respiratory diseases are leading causes of morbidity and their co-occurrence has important implications in mortality and other outcomes. Even the most recent guidelines do not reliably addre...

    Authors: Roberto Tramarin, Mario Polverino, Maurizio Volterrani, Bruna Girardi, Claudio Chimini, Nicolino Ambrosino, Fernando De Benedetto and Cesare Proto

    Citation: Multidisciplinary Respiratory Medicine 2014 9:28

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  41. Content type: Position paper

    COPD is a chronic pathological condition of the respiratory system characterized by persistent and partially reversible airflow obstruction, to which variably contribute remodeling of bronchi (chronic bronchit...

    Authors: Germano Bettoncelli, Francesco Blasi, Vito Brusasco, Stefano Centanni, Antonio Corrado, Fernando De Benedetto, Fausto De Michele, Giuseppe U Di Maria, Claudio F Donner, Franco Falcone, Carlo Mereu, Stefano Nardini, Franco Pasqua, Mario Polverino, Andrea Rossi and Claudio M Sanguinetti

    Citation: Multidisciplinary Respiratory Medicine 2014 9:25

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