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  1. Content type: Original research article

    Non communicable chronic diseases (including respiratory ones) are the leading cause of death and disability. To cope with them we need to redesign the health system, improving primary prevention, screening, a...

    Authors: Stefano Nardini, Gaetano Cicchitto, Fernando De Benedetto, Claudio F Donner, Mario Polverino, Claudio M Sanguinetti and Alberto Visconti

    Citation: Multidisciplinary Respiratory Medicine 2014 9:40

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  2. Content type: State of the art

    A general rationale is presented for withholding and withdrawing medical treatment in end-of-life situations, and an argument is offered for the moral irrelevance of the distinction, both in the context of pha...

    Authors: Massimo Reichlin

    Citation: Multidisciplinary Respiratory Medicine 2014 9:39

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  3. Content type: Original research article

    Chronic respiratory diseases, like bronchial asthma and chronic obstructive pulmonary disease (COPD), are a worldwide health problem. Quantitative and qualitative assessment of asthma and COPD-related research...

    Authors: Waleed M Sweileh, Samah W Al-Jabi, Sa’ed H Zyoud and Ansam F Sawalha

    Citation: Multidisciplinary Respiratory Medicine 2014 9:38

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  4. Content type: Original research article

    Resistance training of peripheral muscles has been recommended in order to increase muscle strength in patients with Chronic Obstructive Pulmonary Disease (COPD). However, whether peripheral muscle strength is...

    Authors: Anne-Kathrin Rausch-Osthoff, Malcolm Kohler, Noriane A Sievi, Christian F Clarenbach and Arnoldus JR van Gestel

    Citation: Multidisciplinary Respiratory Medicine 2014 9:37

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  5. Content type: Review

    Safe removal of tracheal cannula is a major goal in the rehabilitation of tracheostomised patients to achieve progressive independence from mechanical support and reduce the risk of respiratory complications. ...

    Authors: Giancarlo Garuti, Cristina Reverberi, Angelo Briganti, Monica Massobrio, Francesco Lombardi and Mirco Lusuardi

    Citation: Multidisciplinary Respiratory Medicine 2014 9:36

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  6. Content type: Original research article

    Symptoms of COPD are frequently disregarded by patients and also by general practitioners (GPs) in early stages of the disease, that consequently is diagnosed when already at an advanced grade of severity. Und...

    Authors: Claudio M Sanguinetti, Fernando De Benedetto, Claudio F Donner, Stefano Nardini and Alberto Visconti

    Citation: Multidisciplinary Respiratory Medicine 2014 9:35

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  7. Content type: Original research article

    The aim of this study was to analyze the influence of active and passive smoking on cardiorespiratory responses in asymptomatic adults during a sub-maximal-exertion incremental test.

    Authors: Andresa Thier de Borba, Renan Trevisan Jost, Ricardo Gass, Fúlvio Borges Nedel, Dannuey Machado Cardoso, Hildegard Hedwig Pohl, Miriam Beatris Reckziegel, Valeriano Antonio Corbellini and Dulciane Nunes Paiva

    Citation: Multidisciplinary Respiratory Medicine 2014 9:34

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  8. Content type: Short report

    This study aimed to evaluate the clinical value of chest ultrasound (US) in the detection, diagnosis and follow-up of pathologic processes of both peripheral lung parenchyma and pleural space in pregnant women.

    Authors: Riccardo Inchingolo, Andrea Smargiassi, Flaminio Mormile, Roberta Marra, Sara De Carolis, Antonio Lanzone, Salvatore Valente and Giuseppe M Corbo

    Citation: Multidisciplinary Respiratory Medicine 2014 9:32

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  9. Content type: Case report

    Idiopathic pulmonary fibrosis (IPF) is defined as a chronic fibrosing interstitial disease of unknown cause, limited to the lungs, and associated with the histopathologic and/or radiologic pattern of usual int...

    Authors: Gaetano Cicchitto, Valentina Musella, Maria Acitorio, Nicola Capuano, Giuseppe Fiorenzano, Caroline A Owen, Mario Polverino and Francesca Polverino

    Citation: Multidisciplinary Respiratory Medicine 2014 9:31

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  10. Content type: Review

    The purpose of asthma management is to achieve a total asthma control that involves current control and future risk. It has proven efficacy in reducing asthma exacerbations, but the effect size of zafirlukast ...

    Authors: Chao Feng Chen, Yan Lv, Hong Ping Zhang and Gang Wang

    Citation: Multidisciplinary Respiratory Medicine 2014 9:30

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  11. Content type: Original research article

    Aquaporins AQP1 and AQP5 are highly expressed in the lung. Recent studies have shown that the expression of these proteins may be mechanistically involved in the airway inflammation and in the pathogenesis of ...

    Authors: Carmen Calero, Jose Luis López-Campos, Lourdes Gómez Izquierdo, Rocío Sánchez-Silva, Jose Luis López-Villalobos, Francisco J Sáenz-Coronilla, Elena Arellano-Orden, Ana Montes-Worboys and Miriam Echevarría

    Citation: Multidisciplinary Respiratory Medicine 2014 9:29

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  12. Content type: Short report

    Cardiovascular and respiratory diseases are leading causes of morbidity and their co-occurrence has important implications in mortality and other outcomes. Even the most recent guidelines do not reliably addre...

    Authors: Roberto Tramarin, Mario Polverino, Maurizio Volterrani, Bruna Girardi, Claudio Chimini, Nicolino Ambrosino, Fernando De Benedetto and Cesare Proto

    Citation: Multidisciplinary Respiratory Medicine 2014 9:28

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  13. Content type: Position paper

    COPD is a chronic pathological condition of the respiratory system characterized by persistent and partially reversible airflow obstruction, to which variably contribute remodeling of bronchi (chronic bronchit...

    Authors: Germano Bettoncelli, Francesco Blasi, Vito Brusasco, Stefano Centanni, Antonio Corrado, Fernando De Benedetto, Fausto De Michele, Giuseppe U Di Maria, Claudio F Donner, Franco Falcone, Carlo Mereu, Stefano Nardini, Franco Pasqua, Mario Polverino, Andrea Rossi and Claudio M Sanguinetti

    Citation: Multidisciplinary Respiratory Medicine 2014 9:25

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  14. Content type: Short report

    Nowadays, ultrasound techniques have not gained importance in the diagnosis and monitoring of lung pathologies yet because of the high mismatch in acoustic impedance between air and intercostal tissues. Howeve...

    Authors: Libertario Demi, Marcello Demi, Andrea Smargiassi, Riccardo Inchingolo, Francesco Faita and Gino Soldati

    Citation: Multidisciplinary Respiratory Medicine 2014 9:27

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  15. Content type: Original research article

    It remains unknown whether desaturation profiles during daily living are associated with prognosis in patients with chronic obstructive pulmonary disease (COPD). Point measurements of resting oxygen saturation...

    Authors: Seigo Minami, Suguru Yamamoto, Yoshitaka Ogata, Takeshi Nakatani, Yoshiko Takeuchi, Masanari Hamaguchi, Taro Koba and Kiyoshi Komuta

    Citation: Multidisciplinary Respiratory Medicine 2014 9:24

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  16. Content type: Review

    Increased asthma severity is not only associated with enhanced recurrent hospitalization and mortality but also with higher social costs.

    Authors: Gennaro D’Amato, Anna Stanziola, Alessandro Sanduzzi, Gennaro Liccardi, Antonello Salzillo, Carolina Vitale, Antonio Molino, Alessandro Vatrella and Maria D’Amato

    Citation: Multidisciplinary Respiratory Medicine 2014 9:23

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  17. Content type: Short report

    To evaluate the effect of variation of the Arg16Gly polymorphism of the β2-adrenergic receptor gene on clinical response to salmeterol administered with fluticasone propionate in Chinese Han asthmatic patients.

    Authors: Yuying Qiu, Deping Zhang, Yu Qin and Kai-Sheng Yin

    Citation: Multidisciplinary Respiratory Medicine 2014 9:22

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  18. Content type: Original research article

    The purpose of this study was to evaluate the role of ventilatory parameters in maximal exercise performance in elite soccer players.

    Authors: Adriano Di Paco, Giosuè A Catapano, Guido Vagheggini, Stefano Mazzoleni, Matteo Levi Micheli and Nicolino Ambrosino

    Citation: Multidisciplinary Respiratory Medicine 2014 9:20

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  19. Content type: Original research article

    Vitamin D deficiency has been implicated as a factor in a number of infectious and inflammatory lung diseases. In the lung, alveolar macrophages play a key role in inflammation and defense of infection, but th...

    Authors: Alicia K Gerke, Alejandro A Pezzulo, Fan Tang, Joseph E Cavanaugh, Thomas B Bair, Emily Phillips, Linda S Powers and Martha M Monick

    Citation: Multidisciplinary Respiratory Medicine 2014 9:18

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  20. Content type: Original research article

    Denim sandblasting may cause silicosis as a result of free crystalline silica inhalation. Its pathogenesis remains unclear, but autoimmunity may play a role in the development of silicosis. The present study a...

    Authors: Hasan Dogan, Metin Akgun, Omer Araz, Elif Yilmazel Ucar, Ozgur Yoruk, Eda Diyarbakir, Omer Atis, Fatih Akdemir, Hamit Acemoglu and Ibrahim Pirim

    Citation: Multidisciplinary Respiratory Medicine 2014 9:17

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  21. Content type: Original research article

    COPD is characterized by considerable diversity in terms of clinical signs and symptoms, physiopathological mechanisms, response to treatment and disease progression. For this reason, the identification of dif...

    Authors: Maria Sandra Magnoni, Andrea Rizzi, Alberto Visconti and Claudio F Donner

    Citation: Multidisciplinary Respiratory Medicine 2014 9:16

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  22. Content type: Original research article

    Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality at global level even if still underestimated. The insufficient use of specific tools for an objective definition and sta...

    Authors: Roberto W Dal Negro, Luca Bonadiman and Paola Turco

    Citation: Multidisciplinary Respiratory Medicine 2014 9:15

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  23. Content type: State of the art

    Withholding or withdrawing a life-sustaining treatment tends to be very challenging for health care providers, patients, and their family members alike. When a patient’s life seems to be nearing its end, it is...

    Authors: Jos VM Welie and Henk AMJ ten Have

    Citation: Multidisciplinary Respiratory Medicine 2014 9:14

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  24. Content type: Original research article

    To evaluate and compare the diagnostic efficiency of serum (s) and pleural (p) levels of adenosine deaminase (ADA)-1, ADA-2, total ADA, and interferon-gamma (IFN-γ) for the differential diagnosis of pleural tu...

    Authors: Sibel Yurt, Canan Küçükergin, Burcu Arpinar Yigitbas, Şule Seçkin, Hüseyin Cem Tigin and Ayşe Filiz Koşar

    Citation: Multidisciplinary Respiratory Medicine 2014 9:12

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  25. Content type: Original research article

    The mean platelet volume (MPV) reflects the size of platelets. It has been shown to be inversely correlated with level of the inflammation in some chronic inflammatory diseases. This prospective study aims to ...

    Authors: Gulsah Gunluoglu, Esra Ertan Yazar, Nurdan Simsek Veske, Ekrem Cengiz Seyhan and Sedat Altin

    Citation: Multidisciplinary Respiratory Medicine 2014 9:11

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  26. Content type: Original research article

    Chlamydia psittaci (Cp) is a respiratory pathogen capable of inducing acute pulmonary zoonotic disease (psittacosis) or persistent infection. To elucidate the pathogenesis of this infection, a translational large...

    Authors: Carola Ostermann, Susanna Linde, Christiane Siegling-Vlitakis and Petra Reinhold

    Citation: Multidisciplinary Respiratory Medicine 2014 9:10

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    The Erratum to this article has been published in Multidisciplinary Respiratory Medicine 2014 9:42

  27. Content type: Original research article

    Pharmacologic therapies have an important role in the success of interventions for smoking cessation. This study aims to determine the efficacy of several pharmacologic treatments in patients who applied to a ...

    Authors: Elif Yilmazel Ucar, Omer Araz, Nafiye Yilmaz, Metin Akgun, Mehmet Meral, Hasan Kaynar and Leyla Saglam

    Citation: Multidisciplinary Respiratory Medicine 2014 9:9

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  28. Content type: Original research article

    The safety of beta-blockers as a heart rate-limiting drug (HRLD) in patients with acute respiratory failure (ARF) due to chronic obstructive lung disease (COPD) has not been properly assessed in the intensive ...

    Authors: Feyza Kargin, Huriye Berk Takir, Cuneyt Salturk, Nezihe Ciftaslan Goksenoglu, Can Yucel Karabay, Ozlem Yazicioglu Mocin, Nalan Adiguzel, Gokay Gungor, Merih Kalamanoglu Balci, Murat Yalcinsoy, Ramazan Kargin and Zuhal Karakurt

    Citation: Multidisciplinary Respiratory Medicine 2014 9:8

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  29. Content type: Original research article

    Chronic obstructive pulmonary disease (COPD) is a major cause of acute hospital admissions. The main object of our study was to evaluate the effects of telemedicine video-consultation (TVC) on the frequency of...

    Authors: Safaa Saleh, Jan Petter Larsen, Johannes Bergsåker-Aspøy and Heidi Grundt

    Citation: Multidisciplinary Respiratory Medicine 2014 9:6

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  30. Content type: Reviewer acknowledgement

    The editors of Multidisciplinary Respiratory Medicine would like to thank all of our reviewers who have contributed to the journal in Volume 8 (2013).

    Authors: Fernando De Benedetto, Claudio F Donner and Claudio M Sanguinetti

    Citation: Multidisciplinary Respiratory Medicine 2014 9:4

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  31. Content type: Original research article

    Some peptides, which regulate the metabolic balance, are thought to play important roles in nutritional disorders and systemic inflammation in COPD. Treatment of rats with obestatin decreased body-weight gain....

    Authors: Yi Lei, Yasha Liang, Yifan Chen, Xiaojing Liu, Xiaoyang Liao and Fengming Luo

    Citation: Multidisciplinary Respiratory Medicine 2014 9:5

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  32. Content type: Original research article

    Extravascular lung water (EVLW) is a sensitive prognostic indicator of pulmonary edema. Thus, EVLW may be an advantageous method of fluid management. This study aims to evaluate the outcomes of using EVLW and ...

    Authors: Wei Hu, Chang-Wen Lin, Bing-Wei Liu, Wei-Hang Hu and Ying Zhu

    Citation: Multidisciplinary Respiratory Medicine 2014 9:3

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  33. Content type: Original research article

    The distribution of allergens may vary with different geographic areas, suggesting the importance of local epidemiological data to support evidence-based prevention and management of allergic diseases. We inve...

    Authors: Bao-qing Sun, Pei-yan Zheng, Xiao-wen Zhang, Hui-min Huang, De-hui Chen and Guang-qiao Zeng

    Citation: Multidisciplinary Respiratory Medicine 2014 9:2

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  34. Content type: Original research article

    Aspergillus infection was mostly reported with high mortality rates and a bad prognosis in immunocompromised patients, but data were lacking on the clinical characteristics of aspergillus infection in liver cirrh...

    Authors: Jiajia Chen, Qing Yang, Jianrong Huang and Lanjuan Li

    Citation: Multidisciplinary Respiratory Medicine 2014 9:1

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  35. Content type: Review

    The diagnosis of pulmonary embolism (PE) is frequently considered in patients presenting to the emergency department or when hospitalized. Although early treatment is highly effective, PE is underdiagnosed and...

    Authors: Federico Lavorini, Vitantonio Di Bello, Maria Luisa De Rimini, Giovanni Lucignani, Letizia Marconi, Gualtiero Palareti, Raffaele Pesavento, Domenico Prisco, Massimo Santini, Nicola Sverzellati, Antonio Palla and Massimo Pistolesi

    Citation: Multidisciplinary Respiratory Medicine 2013 8:75

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  36. Content type: Original research article

    Different medical therapies are employed in acute lung injury (ALI) but there is still a debate about the efficacy of these drugs. Among these therapies steroids are clinically applied and bosentan is experime...

    Authors: Omer Araz, Elif Demirci, Elif Yilmazel Ucar, Muhammet Calik, Didem Pulur, Adem Karaman, Muhammed Yayla, Eren Altun, Zekai Halici and Metin Akgun

    Citation: Multidisciplinary Respiratory Medicine 2013 8:74

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  37. Content type: Case report

    It can be difficult to perform CT guided biopsy of small pulmonary nodules especially if the position is behind a costa or close to the diaphragm and respiratory movements may hamper the procedure. During apne...

    Authors: Benedict Kjaergaard, Peter R Zepernick, Annette Bergmann, Henrik K Jensen, Milka Mladenovic and Bodil S Rasmussen

    Citation: Multidisciplinary Respiratory Medicine 2013 8:73

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  38. Content type: Review

    Pulmonary Hypertension (PH) associated to chronic respiratory diseases is currently classified in the 3rd group, as a mild to moderate form of pre-capillary PH that progressively complicates the prognosis of asso...

    Authors: Lucio Casali, Pierluigi Carratù and Matteo Sofia

    Citation: Multidisciplinary Respiratory Medicine 2013 8:72

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  39. Content type: Short report

    Indoor air pollution (IAP) constitutes a major global public health problem requiring increasing efforts in research and policymaking that may have special significance for elderly that are likely to spend mos...

    Authors: Isabella Annesi-Maesano, Dan Norback, Jan Zielinski, Alfred Bernard, Cristina Gratziou, Torben Sigsgaard, Piersante Sestini and Giovanni Viegi

    Citation: Multidisciplinary Respiratory Medicine 2013 8:71

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  40. Content type: Original research article

    Despite the gradual improvement in treatment procedures and cure rates of acromegaly, a steady increase in the mortality rate due to respiratory disease has been documented in recent decades. In this study, ou...

    Authors: Gustavo Bittencourt Camilo, Fernando Silva Guimarães, Débora Pedroza Guedes Silva, Roberto Mogami, Leandro Kasuki, Mônica Roberto Gadelha, Pedro Lopes Melo and Agnaldo José Lopes

    Citation: Multidisciplinary Respiratory Medicine 2013 8:70

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  41. Content type: Original research article

    Non-small cell lung cancer (NSCLC) accounts for approximately 80% of new diagnoses of pulmonary carcinoma. This study investigated the correlation between 18 F-fluorodeoxyglucose uptake in computerized tomogra...

    Authors: Mehmet Akif Özgül, Gamze Kirkil, Ekrem Cengiz Seyhan, Erdoğan Çetinkaya, Güler Özgül and Mahmut Yüksel

    Citation: Multidisciplinary Respiratory Medicine 2013 8:69

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  42. Content type: Original research article

    Guidelines advise annual influenza vaccination in chronic asthma. The aim of this study was to determine uptake of the influenza vaccine in a group of patients (n = 146) with moderate to severe chronic asthma ...

    Authors: Rachelle Asciak, Martin Balzan and Jesmar Buttigieg

    Citation: Multidisciplinary Respiratory Medicine 2013 8:68

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  43. Content type: Commentary

    Oxytocin (Sintocynon) is considered an uncommon cause of severe allergic reactions during delivery. We have recently shown that allergic sensitization to latex might constitute an important predisposing risk f...

    Authors: Gennaro Liccardi, Maria Beatrice Bilò, Ciro Mauro, Antonello Salzillo, Amedeo Piccolo, Maria D’Amato, Annabella Liccardi and Gennaro D’Amato

    Citation: Multidisciplinary Respiratory Medicine 2013 8:67

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  44. Content type: Original research article

    The prevalence of sexual dysfunction in patients with COPD is high and its significance has not been sufficiently stressed. The aim of this study is to investigate the incidence of erectile dysfunction (ED) an...

    Authors: Hasan Kahraman, Bilal Sen, Nurhan Koksal, Metin Kilinç and Sefa Resim

    Citation: Multidisciplinary Respiratory Medicine 2013 8:66

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