Articles

A novel diagnostic algorithm for chronic and subacute cough

Cough remains the most common reason for patients to seek medical attention. We practised a novel diagnostic algorithm for chronic and subacute cough.

Authors: Peng Lu, Dan Zhou and Chengzhen Jin

Look at the lung: can chest ultrasonography be useful in pregnancy?

This study aimed to evaluate the clinical value of chest ultrasound (US) in the detection, diagnosis and follow-up of pathologic processes of both peripheral lung parenchyma and pleural space in pregnant women.

Authors: Riccardo Inchingolo, Andrea Smargiassi, Flaminio Mormile, Roberta Marra, Sara De Carolis, Antonio Lanzone, Salvatore Valente and Giuseppe M Corbo

Idiopathic pulmonary fibrosis and coronary artery disease

Idiopathic pulmonary fibrosis (IPF) is defined as a chronic fibrosing interstitial disease of unknown cause, limited to the lungs, and associated with the histopathologic and/or radiologic pattern of usual int...

Authors: Gaetano Cicchitto, Valentina Musella, Maria Acitorio, Nicola Capuano, Giuseppe Fiorenzano, Caroline A Owen, Mario Polverino and Francesca Polverino

Does zafirlukast reduce future risk of asthma exacerbations in adults? Systematic review and meta-analysis

The purpose of asthma management is to achieve a total asthma control that involves current control and future risk. It has proven efficacy in reducing asthma exacerbations, but the effect size of zafirlukast ...

Authors: Chao Feng Chen, Yan Lv, Hong Ping Zhang and Gang Wang

Expression of aquaporins in bronchial tissue and lung parenchyma of patients with chronic obstructive pulmonary disease

Aquaporins AQP1 and AQP5 are highly expressed in the lung. Recent studies have shown that the expression of these proteins may be mechanistically involved in the airway inflammation and in the pathogenesis of ...

Authors: Carmen Calero, Jose Luis López-Campos, Lourdes Gómez Izquierdo, Rocío Sánchez-Silva, Jose Luis López-Villalobos, Francisco J Sáenz-Coronilla, Elena Arellano-Orden, Ana Montes-Worboys and Miriam Echevarría

ISMAR-study presentation: in-hospital epidemiology and clinical management of respiratory and cardiac comorbidities in cardiac and respiratory disease units

Cardiovascular and respiratory diseases are leading causes of morbidity and their co-occurrence has important implications in mortality and other outcomes. Even the most recent guidelines do not reliably addre...

Authors: Roberto Tramarin, Mario Polverino, Maurizio Volterrani, Bruna Girardi, Claudio Chimini, Nicolino Ambrosino, Fernando De Benedetto and Cesare Proto

Integrating COPD care in Italy

Authors: Peter MA Calverley

The clinical and integrated management of COPD. An official document of AIMAR (Interdisciplinary Association for Research in Lung Disease), AIPO (Italian Association of Hospital Pulmonologists), SIMER (Italian Society of Respiratory Medicine), SIMG (Italian Society of General Medicine)

COPD is a chronic pathological condition of the respiratory system characterized by persistent and partially reversible airflow obstruction, to which variably contribute remodeling of bronchi (chronic bronchit...

Authors: Germano Bettoncelli, Francesco Blasi, Vito Brusasco, Stefano Centanni, Antonio Corrado, Fernando De Benedetto, Fausto De Michele, Giuseppe U Di Maria, Claudio F Donner, Franco Falcone, Carlo Mereu, Stefano Nardini, Franco Pasqua, Mario Polverino, Andrea Rossi and Claudio M Sanguinetti

Ultrasonography in lung pathologies: new perspectives

Nowadays, ultrasound techniques have not gained importance in the diagnosis and monitoring of lung pathologies yet because of the high mismatch in acoustic impedance between air and intercostal tissues. Howeve...

Authors: Libertario Demi, Marcello Demi, Andrea Smargiassi, Riccardo Inchingolo, Francesco Faita and Gino Soldati

Ambulatory pulse oximetry monitoring in Japanese COPD outpatients not receiving oxygen therapy

It remains unknown whether desaturation profiles during daily living are associated with prognosis in patients with chronic obstructive pulmonary disease (COPD). Point measurements of resting oxygen saturation...

Authors: Seigo Minami, Suguru Yamamoto, Yoshitaka Ogata, Takeshi Nakatani, Yoshiko Takeuchi, Masanari Hamaguchi, Taro Koba and Kiyoshi Komuta

Treating severe allergic asthma with anti-IgE monoclonal antibody (omalizumab): a review

Increased asthma severity is not only associated with enhanced recurrent hospitalization and mortality but also with higher social costs.

Authors: Gennaro D’Amato, Anna Stanziola, Alessandro Sanduzzi, Gennaro Liccardi, Antonello Salzillo, Carolina Vitale, Antonio Molino, Alessandro Vatrella and Maria D’Amato

Effect of β₂ -adrenergic receptor gene Arg16Gly polymorphisms on response to long-acting β₂-agonist in Chinese Han asthmatic patients

To evaluate the effect of variation of the Arg16Gly polymorphism of the β₂-adrenergic receptor gene on clinical response to salmeterol administered with fluticasone propionate in Chinese Han asthmatic patients.

Authors: Yuying Qiu, Deping Zhang, Yu Qin and Kai-Sheng Yin

Lung, not only heart

Authors: Annalisa Cogo

Ventilatory response to exercise of elite soccer players

The purpose of this study was to evaluate the role of ventilatory parameters in maximal exercise performance in elite soccer players.

Authors: Adriano Di Paco, Giosuè A Catapano, Guido Vagheggini, Stefano Mazzoleni, Matteo Levi Micheli and Nicolino Ambrosino

The lungs need to be deflated: effects of glycopyrronium on lung hyperinflation in COPD patients

Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation caused by bronchial alterations, small airways disease and parenchymal destruction. In patients with COPD the stru...

Authors: Claudio M Sanguinetti

Effects of vitamin D supplementation on alveolar macrophage gene expression: preliminary results of a randomized, controlled trial

Vitamin D deficiency has been implicated as a factor in a number of infectious and inflammatory lung diseases. In the lung, alveolar macrophages play a key role in inflammation and defense of infection, but th...

Authors: Alicia K Gerke, Alejandro A Pezzulo, Fan Tang, Joseph E Cavanaugh, Thomas B Bair, Emily Phillips, Linda S Powers and Martha M Monick

The association of human leukocyte antigen polymorphisms with disease severity and latency period in patients with silicosis

Denim sandblasting may cause silicosis as a result of free crystalline silica inhalation. Its pathogenesis remains unclear, but autoimmunity may play a role in the development of silicosis. The present study a...

Authors: Hasan Dogan, Metin Akgun, Omer Araz, Elif Yilmazel Ucar, Ozgur Yoruk, Eda Diyarbakir, Omer Atis, Fatih Akdemir, Hamit Acemoglu and Ibrahim Pirim

AIMAR survey on COPD phenotypes

COPD is characterized by considerable diversity in terms of clinical signs and symptoms, physiopathological mechanisms, response to treatment and disease progression. For this reason, the identification of dif...

Authors: Maria Sandra Magnoni, Andrea Rizzi, Alberto Visconti and Claudio F Donner

Sensitivity of the COPD assessment test (CAT questionnaire) investigated in a population of 681 consecutive patients referring to a lung clinic: the first Italian specific study

Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality at global level even if still underestimated. The insufficient use of specific tools for an objective definition and sta...

Authors: Roberto W Dal Negro, Luca Bonadiman and Paola Turco

The ethics of forgoing life-sustaining treatment: theoretical considerations and clinical decision making

Withholding or withdrawing a life-sustaining treatment tends to be very challenging for health care providers, patients, and their family members alike. When a patient’s life seems to be nearing its end, it is...

Authors: Jos VM Welie and Henk AMJ ten Have

The withholding/withdrawing distinction in the end-of-life debate

Authors: Virginia Sanchini, Cecilia Nardini and Giovanni Boniolo

Diagnostic utility of serum and pleural levels of adenosine deaminase 1–2, and interferon-γ in the diagnosis of pleural tuberculosis

To evaluate and compare the diagnostic efficiency of serum (s) and pleural (p) levels of adenosine deaminase (ADA)-1, ADA-2, total ADA, and interferon-gamma (IFN-γ) for the differential diagnosis of pleural tu...

Authors: Sibel Yurt, Canan Küçükergin, Burcu Arpinar Yigitbas, Şule Seçkin, Hüseyin Cem Tigin and Ayşe Filiz Koşar

Mean platelet volume as an inflammation marker in active pulmonary tuberculosis

The mean platelet volume (MPV) reflects the size of platelets. It has been shown to be inversely correlated with level of the inflammation in some chronic inflammatory diseases. This prospective study aims to ...

Authors: Gulsah Gunluoglu, Esra Ertan Yazar, Nurdan Simsek Veske, Ekrem Cengiz Seyhan and Sedat Altin

Evaluation of pulmonary dysfunctions and acid–base imbalances induced by Chlamydia psittaci in a bovine model of respiratory infection

Chlamydia psittaci (Cp) is a respiratory pathogen capable of inducing acute pulmonary zoonotic disease (psittacosis) or persistent infection. To elucidate the pathogenesis of this infection, a translational large...

Authors: Carola Ostermann, Susanna Linde, Christiane Siegling-Vlitakis and Petra Reinhold

Effectiveness of pharmacologic therapies on smoking cessation success: three years results of a smoking cessation clinic

Pharmacologic therapies have an important role in the success of interventions for smoking cessation. This study aims to determine the efficacy of several pharmacologic treatments in patients who applied to a ...

Authors: Elif Yilmazel Ucar, Omer Araz, Nafiye Yilmaz, Metin Akgun, Mehmet Meral, Hasan Kaynar and Leyla Saglam

The safety of beta-blocker use in chronic obstructive pulmonary disease patients with respiratory failure in the intensive care unit

The safety of beta-blockers as a heart rate-limiting drug (HRLD) in patients with acute respiratory failure (ARF) due to chronic obstructive lung disease (COPD) has not been properly assessed in the intensive ...

Authors: Feyza Kargin, Huriye Berk Takir, Cuneyt Salturk, Nezihe Ciftaslan Goksenoglu, Can Yucel Karabay, Ozlem Yazicioglu Mocin, Nalan Adiguzel, Gokay Gungor, Merih Kalamanoglu Balci, Murat Yalcinsoy, Ramazan Kargin and Zuhal Karakurt

A combination of predispositions and exposures as responsible for acute eosinophilic pneumonia

Acute eosinophilic pneumonia (AEP) is a rare febrile illness which is characterized by respiratory failure and often requires mechanical ventilation. The causes and sequence of events of this disease at a bioc...

Authors: Simona Amiconi and Bertrand Hirl

Re-admissions to hospital and patient satisfaction among patients with chronic obstructive pulmonary disease after telemedicine video consultation - a retrospective pilot study

Chronic obstructive pulmonary disease (COPD) is a major cause of acute hospital admissions. The main object of our study was to evaluate the effects of telemedicine video-consultation (TVC) on the frequency of...

Authors: Safaa Saleh, Jan Petter Larsen, Johannes Bergsåker-Aspøy and Heidi Grundt

Reviewer acknowledgement 2013

The editors of Multidisciplinary Respiratory Medicine would like to thank all of our reviewers who have contributed to the journal in Volume 8 (2013).

Authors: Fernando De Benedetto, Claudio F Donner and Claudio M Sanguinetti

Increased circulating obestatin in patients with chronic obstructive pulmonary disease

Some peptides, which regulate the metabolic balance, are thought to play important roles in nutritional disorders and systemic inflammation in COPD. Treatment of rats with obestatin decreased body-weight gain....

Authors: Yi Lei, Yasha Liang, Yifan Chen, Xiaojing Liu, Xiaoyang Liao and Fengming Luo

Extravascular lung water and pulmonary arterial wedge pressure for fluid management in patients with acute respiratory distress syndrome

Extravascular lung water (EVLW) is a sensitive prognostic indicator of pulmonary edema. Thus, EVLW may be an advantageous method of fluid management. This study aims to evaluate the outcomes of using EVLW and ...

Authors: Wei Hu, Chang-Wen Lin, Bing-Wei Liu, Wei-Hang Hu and Ying Zhu

Prevalence of allergen sensitization among patients with allergic diseases in Guangzhou, Southern China: a four-year observational study

The distribution of allergens may vary with different geographic areas, suggesting the importance of local epidemiological data to support evidence-based prevention and management of allergic diseases. We inve...

Authors: Bao-qing Sun, Pei-yan Zheng, Xiao-wen Zhang, Hui-min Huang, De-hui Chen and Guang-qiao Zeng

Clinical findings in 19 cases of invasive pulmonary aspergillosis with liver cirrhosis

Aspergillus infection was mostly reported with high mortality rates and a bad prognosis in immunocompromised patients, but data were lacking on the clinical characteristics of aspergillus infection in liver cirrh...

Authors: Jiajia Chen, Qing Yang, Jianrong Huang and Lanjuan Li

Diagnosis and treatment of pulmonary embolism: a multidisciplinary approach

The diagnosis of pulmonary embolism (PE) is frequently considered in patients presenting to the emergency department or when hospitalized. Although early treatment is highly effective, PE is underdiagnosed and...

Authors: Federico Lavorini, Vitantonio Di Bello, Maria Luisa De Rimini, Giovanni Lucignani, Letizia Marconi, Gualtiero Palareti, Raffaele Pesavento, Domenico Prisco, Massimo Santini, Nicola Sverzellati, Antonio Palla and Massimo Pistolesi

Comparison of reducing effect on lung injury of dexamethasone and bosentan in acute lung injury: an experimental study

Different medical therapies are employed in acute lung injury (ALI) but there is still a debate about the efficacy of these drugs. Among these therapies steroids are clinically applied and bosentan is experime...

Authors: Omer Araz, Elif Demirci, Elif Yilmazel Ucar, Muhammet Calik, Didem Pulur, Adem Karaman, Muhammed Yayla, Eren Altun, Zekai Halici and Metin Akgun

CT-guided needle lung biopsy is possible during apneic oxygenation: a case series

It can be difficult to perform CT guided biopsy of small pulmonary nodules especially if the position is behind a costa or close to the diaphragm and respiratory movements may hamper the procedure. During apne...

Authors: Benedict Kjaergaard, Peter R Zepernick, Annette Bergmann, Henrik K Jensen, Milka Mladenovic and Bodil S Rasmussen

Clinical variability of respiratory pulmonary hypertension: implications for diagnosis and management

Pulmonary Hypertension (PH) associated to chronic respiratory diseases is currently classified in the 3^rd group, as a mild to moderate form of pre-capillary PH that progressively complicates the prognosis of asso...

Authors: Lucio Casali, Pierluigi Carratù and Matteo Sofia

Geriatric study in Europe on health effects of air quality in nursing homes (GERIE study) profile: objectives, study protocol and descriptive data

Indoor air pollution (IAP) constitutes a major global public health problem requiring increasing efforts in research and policymaking that may have special significance for elderly that are likely to spend mos...

Authors: Isabella Annesi-Maesano, Dan Norback, Jan Zielinski, Alfred Bernard, Cristina Gratziou, Torben Sigsgaard, Piersante Sestini and Giovanni Viegi

Pulmonary function testing and chest tomography in patients with acromegaly

Despite the gradual improvement in treatment procedures and cure rates of acromegaly, a steady increase in the mortality rate due to respiratory disease has been documented in recent decades. In this study, ou...

Authors: Gustavo Bittencourt Camilo, Fernando Silva Guimarães, Débora Pedroza Guedes Silva, Roberto Mogami, Leandro Kasuki, Mônica Roberto Gadelha, Pedro Lopes Melo and Agnaldo José Lopes

The maximum standardized FDG uptake on PET-CT in patients with non-small cell lung cancer

Non-small cell lung cancer (NSCLC) accounts for approximately 80% of new diagnoses of pulmonary carcinoma. This study investigated the correlation between 18 F-fluorodeoxyglucose uptake in computerized tomogra...

Authors: Mehmet Akif Özgül, Gamze Kirkil, Ekrem Cengiz Seyhan, Erdoğan Çetinkaya, Güler Özgül and Mahmut Yüksel

Predictors of seasonal influenza vaccination in chronic asthma

Guidelines advise annual influenza vaccination in chronic asthma. The aim of this study was to determine uptake of the influenza vaccine in a group of patients (n = 146) with moderate to severe chronic asthma ...

Authors: Rachelle Asciak, Martin Balzan and Jesmar Buttigieg

Oxytocin: an unexpected risk for cardiologic and broncho-obstructive effects, and allergic reactions in susceptible delivering women

Oxytocin (Sintocynon) is considered an uncommon cause of severe allergic reactions during delivery. We have recently shown that allergic sensitization to latex might constitute an important predisposing risk f...

Authors: Gennaro Liccardi, Maria Beatrice Bilò, Ciro Mauro, Antonello Salzillo, Amedeo Piccolo, Maria D’Amato, Annabella Liccardi and Gennaro D’Amato

Erectile dysfunction and sex hormone changes in chronic obstructive pulmonary disease patients

The prevalence of sexual dysfunction in patients with COPD is high and its significance has not been sufficiently stressed. The aim of this study is to investigate the incidence of erectile dysfunction (ED) an...

Authors: Hasan Kahraman, Bilal Sen, Nurhan Koksal, Metin Kilinç and Sefa Resim

CD24⁺/CD38^- as new prognostic marker for non-small cell lung cancer

Lung cancer is the leading cause of death among cancers in the world. The annual death toll due to this disease exceeds the combined deaths caused by colon, breast, prostate, and pancreatic cancers. As a resul...

Authors: Feridoun Karimi-Busheri, Aghdass Rasouli-Nia, Victoria Zadorozhny and Habib Fakhrai

Effect of thyroid function on COPD exacerbation frequency: a preliminary study

Frequent exacerbations of chronic obstructive pulmonary disease (COPD) have negative effects on quality of life and survival. Thus, factors related to exacerbations should be determined. We aimed to evaluate t...

Authors: Sevinc Sarinc Ulasli, Serife Savas Bozbas, Zeynep Erayman Ozen, Berna Akinci Ozyurek and Gaye Ulubay

The relationship between C-reactive protein and prognostic factors in chronic obstructive pulmonary disease

The purpose of the study was to determine the relationship between high sensitivity C-reactive protein (hs-CRP) levels and prognostic factors in chronic obstructive pulmonary disease.

Authors: Reshu Agarwal, Mohammad Shoaib Zaheer, Zubair Ahmad and Jamal Akhtar

Leptin, ghrelin and calprotectin: inflammatory markers in childhood asthma?

Appetite-modulating hormones ghrelin and leptin might be relevant to asthma with their pro-inflammatory effects, and calprotectin has been recognized as a promising marker of inflammation. The purpose of this ...

Authors: Nazan Cobanoglu, Nilufer Galip, Ceyhun Dalkan and Nerin Nadir Bahceciler

Metabolic syndrome and carotid intima-media thickness in chronic obstructive pulmonary disease

The aim of this study is to investigate the prevalence of metabolic syndrome (MetS), carotid intima media thickness (IMT), and serum C-reactive protein (CRP) levels in patients with chronic obstructive pulmona...

Authors: Aylin Ozgen Alpaydin, Isin Konyar Arslan, Selim Serter, Aysin Sakar Coskun, Pinar Celik, Fatma Taneli and Arzu Yorgancioglu

Obesity can influence children’s and adolescents’ airway hyperresponsiveness differently

Literature is still arguing about a possible relationship between airway hyperresponsiveness (AHR) and body mass index (BMI). This study aimed at evaluating the influence of BMI on AHR and pulmonary function i...

Authors: Bruno Sposato, Marco Scalese, Maria Giovanna Migliorini, Maria Piera Riccardi, Massimo Tosti Balducci, Luigi Petruzzelli and Raffaele Scala

Invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease

Invasive pulmonary aspergillosis (IPA) is an infection often occurring in neutropenic patients and has high mortality rates. In recent years, it has been reported that the incidence of IPA has also increased i...

Authors: Nuri Tutar, Gokhan Metan, Ayşe Nedret Koç, Insu Yilmaz, Ilkay Bozkurt, Zuhal Ozer Simsek, Hakan Buyukoglan, Asiye Kanbay, Fatma Sema Oymak, Inci Gulmez and Ramazan Demir