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  1. Oxidants have long been recognized to have an important role in the pathogenesis of COPD, and in this cigarette smoke has a strong responsibility, because it generates a conspicuous amount of oxidant radicals ...

    Authors: Claudio M. Sanguinetti

    Citation: Multidisciplinary Respiratory Medicine 2016 11:8

    Content type: Review

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  2. Asthma and chronic obstructive pulmonary disease (COPD) are disorders of the lungs characterized by airflow obstruction, inflammation and tissue remodeling. Management of patients with these diseases is comple...

    Authors: Silvia Sommariva, Aureliano P. Finch and Claudio Jommi

    Citation: Multidisciplinary Respiratory Medicine 2016 11:4

    Content type: Original research article

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  3. Indoor smoking in public places and workplaces is forbidden in Italy since 2003, but some health concerns are arising from outdoor secondhand smoke (SHS) exposure for non-smokers. One of the biggest Italian St...

    Authors: Cinzia De Marco, Ario Alberto Ruprecht, Paolo Pozzi, Elena Munarini, Anna Chiara Ogliari, Roberto Mazza and Roberto Boffi

    Citation: Multidisciplinary Respiratory Medicine 2016 11:2

    Content type: Original research article

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    The Erratum to this article has been published in Multidisciplinary Respiratory Medicine 2016 11:11

  4. Chronic obstructive pulmonary disease (COPD) impairs physical status and impacts on mental health. This prospective study was designed to assess associations between mental health and systemic biomarkers, and ...

    Authors: Christian Zilz, Stefan H. Blaas, Michael Pfeifer, Rudolf A. Jörres and Stephan Budweiser

    Citation: Multidisciplinary Respiratory Medicine 2016 11:3

    Content type: Original research article

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  5. The major changes to our world are those involving the atmosphere and the climate, including global warming induced by anthropogenic factors, with impact on the biosphere and human environment. Studies on the ...

    Authors: Gennaro D’Amato, Carolina Vitale, Annamaria De Martino, Giovanni Viegi, Maurizia Lanza, Antonio Molino, Alessandro Sanduzzi, Alessandro Vatrella, Isabella Annesi-Maesano and Maria D’Amato

    Citation: Multidisciplinary Respiratory Medicine 2015 10:39

    Content type: Review

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  6. Tuberculosis (TB), Lung Cancer (LC) and Chronic Obstructive Pulmonary Diseases (COPD) affect millions of individuals worldwide. Monitoring of DNA damage in pathological situations has been investigated because...

    Authors: Andréa Lúcia Gonçalves da Silva, Maribel Josimara Bresciani, Thaís Evelyn Karnopp, Augusto Ferreira Weber, Joel Henrique Ellwanger, João Antonio Pêgas Henriques, Andréia Rosane de Moura Valim and Lia Gonçalves Possuelo

    Citation: Multidisciplinary Respiratory Medicine 2015 10:38

    Content type: Original research article

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  7. The use of evaluation tools such as the manovacuometer and respirometer is frequent and disinfection is usually limited to the external surfaces, which is insufficient and raises concerns because of the potent...

    Authors: Jeanette Janaina Jaber Lucato, Thiago Marraccini Nogueira da Cunha, Sara Solange Oliveira Costa Rocha, Fernanda Maria Palmieri de Carvalho, Daniele Cristina Botega, Jamili Anbar Torquato, Ana Cristina Gimenes and Renato Fraga Righetti

    Citation: Multidisciplinary Respiratory Medicine 2015 11:1

    Content type: Original research article

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  8. Respiratory disease accounts for a large proportion of emergency admissions to hospital and diseaseassociated mortality. Genetic association studies demonstrate a link between iron metabolism and pulmonary dis...

    Authors: Heena Khiroya and Alice M. Turner

    Citation: Multidisciplinary Respiratory Medicine 2015 10:34

    Content type: Review

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  9. Exertional dyspnea is a hallmark symptom of fibrosing interstitial lung disease (fILD), and oxygen (O2) desaturation is common among patients with fILD. Supplemental O2 is prescribed to maintain normoxia and alle...

    Authors: Mengshu Cao, Frederick S. Wamboldt, Kevin K. Brown, Jonathon Hickman, Amy L. Olson, Joshua J. Solomon and Jeffrey J. Swigris

    Citation: Multidisciplinary Respiratory Medicine 2015 10:37

    Content type: Original Research Article

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  10. Weaning from tracheostomy has implications in management, quality of life, and costs of ventilated patients. Furthermore, endotracheal cannula removing needs further studies. Aim of this study was the validati...

    Authors: Franco Pasqua, Ilaria Nardi, Alessia Provenzano and Alessia Mari

    Citation: Multidisciplinary Respiratory Medicine 2015 10:35

    Content type: Original research article

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  11. Inflammatory airway disease (IAD) in horses, similar to asthma in humans, is a common cause of chronic poor respiratory health and exercise intolerance due to airway inflammation and exaggerated airway constri...

    Authors: Ashley Houtsma, Daniela Bedenice, Nicola Pusterla, Brenna Pugliese, Samantha Mapes, Andrew M Hoffman, Julia Paxson, Elizabeth Rozanski, Jean Mukherjee, Margaret Wigley and Melissa R. Mazan

    Citation: Multidisciplinary Respiratory Medicine 2015 10:33

    Content type: Original research article

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  12. There is limited evidence supporting the routine use of palivizumab in paediatric cystic fibrosis (CF) patients to reduce respiratory syncytial virus (RSV) infection and related hospitalisation. Despite this, ...

    Authors: Barry Linnane, Miranda G. Kiernan, Nuala H. O’Connell, Linda Kearse and Colum P. Dunne

    Citation: Multidisciplinary Respiratory Medicine 2015 10:32

    Content type: Letter to the Editor

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  13. This paper summarizes the Part 1 of the proceedings of the 8th International Conference on Management and Rehabilitation of Chronic Respiratory Failure, held in Pescara, Italy, on 7 and 8 May, 2015. It summarizes...

    Authors: Nicolino Ambrosino, Richard Casaburi, Alfredo Chetta, Enrico Clini, Claudio F. Donner, Michael Dreher, Roger Goldstein, Amal Jubran, Linda Nici, Caroline A. Owen, Carolyn Rochester, Martin J. Tobin, Guido Vagheggini, Michele Vitacca and Richard ZuWallack

    Citation: Multidisciplinary Respiratory Medicine 2015 10:31

    Content type: Meeting report

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  14. This paper summarizes the Part 2 of the proceedings of the 8th International Conference on Management and Rehabilitation of Chronic Respiratory Failure, held in Pescara, Italy, on 7 and 8 May, 2015. It summarizes...

    Authors: Nicolino Ambrosino, Richard Casaburi, Alfredo Chetta, Enrico Clini, Claudio F. Donner, Michael Dreher, Roger Goldstein, Amal Jubran, Linda Nici, Caroline A. Owen, Carolyn Rochester, Martin J. Tobin, Guido Vagheggini, Michele Vitacca and Richard ZuWallack

    Citation: Multidisciplinary Respiratory Medicine 2015 10:30

    Content type: Meeting report

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  15. This paper summarizes the Part 3 of the proceedings of the 8th International Conference on Management and Rehabilitation of Chronic Respiratory Failure, held in Pescara, Italy, on 7 and 8 May, 2015. It summarizes...

    Authors: Nicolino Ambrosino, Richard Casaburi, Alfredo Chetta, Enrico Clini, Claudio F. Donner, Michael Dreher, Roger Goldstein, Amal Jubran, Linda Nici, Caroline A. Owen, Carolyn Rochester, Martin J. Tobin, Guido Vagheggini, Michele Vitacca and Richard ZuWallack

    Citation: Multidisciplinary Respiratory Medicine 2015 10:29

    Content type: Meeting report

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  16. Venous thromboembolism (VTE) is a common complication of malignancies and epidemiological studies suggest that lung cancer belonged to the group of malignancies with the highest incidence rates of VTE. Risk fa...

    Authors: Carolina Vitale, Maria D’Amato, Paolo Calabrò, Anna Agnese Stanziola, Mauro Mormile and Antonio Molino

    Citation: Multidisciplinary Respiratory Medicine 2015 10:28

    Content type: Review

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  17. Polymorphisms in the vitamin D receptor (VDR) gene have been studied in immune-related disorders either as independent contributors or in combination with vitamin D concentration. Vitamin D and VDR have been i...

    Authors: Anna Papadopoulou, Panayiotis Kouis, Nikos Middleton, Ourania Kolokotroni, Themistokles Karpathios, Polyxeni Nicolaidou and Panayiotis K. Yiallouros

    Citation: Multidisciplinary Respiratory Medicine 2015 10:26

    Content type: Original research article

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  18. The effectiveness of a homeopathic syrup on cough has been demonstrated in an adult population in a previous double-blind randomized study. The present prospective observational study investigated children aff...

    Authors: Alessandro Zanasi, Salvatore Cazzato, Massimiliano Mazzolini, Carla Maria Sofia Ierna, Marianna Mastroroberto, Elena Nardi and Antonio Maria Morselli-Labate

    Citation: Multidisciplinary Respiratory Medicine 2015 10:25

    Content type: Original Research Article

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  19. Several comorbidities frequently affect COPD progression. Aim of the study was to assess the prevalence of main comorbidities by gender and disease severity in a cohort of COPD patients referring for the first ti...

    Authors: R. W. Dal Negro, L. Bonadiman and P. Turco

    Citation: Multidisciplinary Respiratory Medicine 2015 10:24

    Content type: Original research article

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  20. The Body Mass Index (BMI) is a widely used parameter to study obesity; however it does not assess the distribution of body adiposity. Ultrasonography is a reliable method of measuring subcutaneous (SAT), visce...

    Authors: Zied Rasslan, Roberto Stirbulov, Roberto Saad Junior, Sergio Tercio Curia, Carlos Alberto da Conceição Lima, Eduardo Araújo Perez, Ezequiel Fernandes Oliveira, Claudio Ferdinando Donner and Luis Vicente Franco Oliveira

    Citation: Multidisciplinary Respiratory Medicine 2015 10:23

    Content type: Original research article

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  21. Involvement of the small airways may be related to increased severity and increased demand for health care services and incurring in high costs, private or for the healthcare system. The hyperinflation consequ...

    Authors: J.F. Castelluccio, R. Stirbulov, E.A. Perez, J.C.M. Oliveira, C.F. Donner, L.V.F. Oliveira and Z. Rasslan

    Citation: Multidisciplinary Respiratory Medicine 2015 10:22

    Content type: Original research article

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  22. Recent studies investigating the health effects of air pollution have proven an existing impact around and below international air quality guidelines and standards. These studies were based on accessible data ...

    Authors: Myriam Mrad Nakhlé, Wehbeh Farah, Nelly Ziade, Maher Abboud, Marie-Louise Coussa-Koniski and Isabella Annesi-Maesano

    Citation: Multidisciplinary Respiratory Medicine 2015 10:21

    Content type: Original research article

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  23. Asthma is a serious chronic inflammatory disease affecting 300 million people worldwide. This aim of this study to investigate the anti-inflammatory and anti-asthmatic effects of Laminaria japonica extract in the...

    Authors: Rongjun Lin, Xiaomei Liu, Yan Meng, Mei Xu and Jianping Guo

    Citation: Multidisciplinary Respiratory Medicine 2015 10:20

    Content type: Original research article

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  24. Cough is one of the most common symptoms for which patients seek medical attention from primary care physicians and lung specialists. About 40% of the population at any one time report cough.

    Authors: Alessandro Zanasi, Luigi Lanata, Giovanni Fontana, Federico Saibene, Peter Dicpinigaitis and Francesco De Blasio

    Citation: Multidisciplinary Respiratory Medicine 2015 10:19

    Content type: Original Research Article

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  25. Kartagener Syndrome (KS) is a rare autosomal recessive genetic disorder, resulting in a group of clinical manifestations, including bronchiectasis, chronic pansinusitis and situs inversus.

    Authors: Nicola Ciancio, Maria Margherita de Santi, Raffaele Campisi, Laura Amato, Giuseppina Di Martino and Giuseppe Di Maria

    Citation: Multidisciplinary Respiratory Medicine 2015 10:18

    Content type: Review

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  26. Chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory condition which can lead to comorbidities of variable severity, cognitive dysfunction included. The role of supplemental oxygen in prev...

    Authors: Roberto W Dal Negro, Luca Bonadiman, Fernanda P Bricolo, Silvia Tognella and Paola Turco

    Citation: Multidisciplinary Respiratory Medicine 2015 10:17

    Content type: Original research article

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  27. Horses commonly suffer from chronic respiratory disease and are also used in large animal models of spontaneous or induced airway inflammation. The anti-inflammatory properties of curcumin are largely describe...

    Authors: Charlotte Sandersen, Dorothee Bienzle, Simona Cerri, Thierry Franck, Sandrine Derochette, Philippe Neven, Ange Mouytis-Mickalad and Didier Serteyn

    Citation: Multidisciplinary Respiratory Medicine 2015 10:16

    Content type: Original research article

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  28. We herein report a case of invasive candidiasis presenting rare findings on chest computed tomography (CT). The chest CT scan showed multiple small cavitary lesions and nodules with surrounding ground-glass op...

    Authors: Yuichiro Yasuda, Kazunori Tobino, Mina Asaji, Yoshikazu Yamaji and Kosuke Tsuruno

    Citation: Multidisciplinary Respiratory Medicine 2015 10:11

    Content type: Case report

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  29. Bronchial thermoplasty (BT) is a new therapeutic option for severe refractory asthma not controlled despite high dose inhaled corticosteroids plus long-acting bronchodilators and omalizumab in selected cases. ...

    Authors: Nicola Facciolongo, Francesco Menzella, Mirco Lusuardi, Roberto Piro, Carla Galeone, Claudia Castagnetti, Alberto Cavazza, Cristiano Carbonelli, Luigi Zucchi and Pier Paolo Salsi

    Citation: Multidisciplinary Respiratory Medicine 2015 10:9

    Content type: Case report

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  30. Data for the U.S adult population from the National Health and Nutrition Examination Survey (NHANES) were used to evaluate risk factors for a restrictive pattern on spirometry and estimate the change in its pr...

    Authors: Laura Kurth and Eva Hnizdo

    Citation: Multidisciplinary Respiratory Medicine 2015 10:7

    Content type: Original research article

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  31. Withholding and withdrawing a treatment already established are two forms of limitation of the therapeutic effort (LTE). The question of undergoing or not undergoing lifesaving medical treatments is not restri...

    Authors: Patrizia Borsellino

    Citation: Multidisciplinary Respiratory Medicine 2015 10:5

    Content type: State of the art

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  32. The editors of Multidisciplinary Respiratory Medicine would like to thank all of our reviewers who have contributed to the journal in Volume 9 (2014).

    Authors: Fernando De Benedetto, Claudio F Donner and Claudio M Sanguinetti

    Citation: Multidisciplinary Respiratory Medicine 2015 10:2

    Content type: Reviewer acknowledgement

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  33. Chronic Obstructive Pulmonary Disease (COPD) is characterized by respiratory and extrarespiratory components referring both to systemic complications of COPD, like skeletal muscle myopathy, weight loss and oth...

    Authors: Giorgio Fumagalli, Fabrizio Fabiani, Silvia Forte, Massimiliano Napolitano, Giovanni Balzano, Matteo Bonini, Giuseppe De Simone, Salvatore Fuschillo, Antonella Pentassuglia, Franco Pasqua, Pietro Alimonti, Stefano Carlone and Claudio M Sanguinetti

    Citation: Multidisciplinary Respiratory Medicine 2015 10:4

    Content type: Original research article

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  34. The adequate control of asthma includes the absence of nocturnal symptoms, minimal use of medication, normal or nearly normal lung function and no limitations to physical activity. The choice of a more sedenta...

    Authors: Elisangela Ramos, Luis Vicente Franco de Oliveira, Audrey Borghi Silva, Ivan Peres Costa, João Carlos Ferrari Corrêa, Dirceu Costa, Vera Lucia Alves, Claudio F Donner, Roberto Stirbulov, Ross Arena and Luciana Malosa Sampaio

    Citation: Multidisciplinary Respiratory Medicine 2015 10:3

    Content type: Original research article

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  35. Patients with severe asthma or COPD have often a suboptimal symptom control due to inadequate treatment. A better understanding of pathogenetic mechanisms, phenotypes, endotypes and the new technologies availa...

    Authors: Francesco Menzella, Mirco Lusuardi, Carla Galeone and Luigi Zucchi

    Citation: Multidisciplinary Respiratory Medicine 2015 10:1

    Content type: Review

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  36. Chronic Obstructive Pulmonary Disease (COPD) ranks third as cause of mortality and disability-adjusted life years (DALY) worldwide and also in Italy it imposes a huge health, social and economic load. Early sy...

    Authors: Claudio M Sanguinetti, Nicolino Ambrosino, Filippo Andò, Fernando De Benedetto, Claudio F Donner, Stefano Nardini, Mario Polverino, Roberto Torchio, Guido Vagheggini and Alberto Visconti

    Citation: Multidisciplinary Respiratory Medicine 2014 9:65

    Content type: Original research article

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  37. Chronic obstructive pulmonary disease (COPD) is a widespread respiratory disorder, usually characterized by progressive and poorly reversible airflow limitation. Inhaled long-acting bronchodilators, namely LAB...

    Authors: Girolamo Pelaia, Rosario Maselli and Luca Gallelli

    Citation: Multidisciplinary Respiratory Medicine 2014 9:64

    Content type: Review

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  38. This article deals with the prevalence and the possible reasons of COPD underestimation in the population and gives suggestions on how to overcome the obstacles and make the correct diagnosis in order to provi...

    Authors: Stefano Carlone, Bruno Balbi, Michela Bezzi, Marco Brunori, Stefano Calabro, Maria Pia Foschino Barbaro, Claudio Micheletto, Salvatore Privitera, Roberto Torchio, Pietro Schino and Andrea Vianello

    Citation: Multidisciplinary Respiratory Medicine 2014 9:63

    Content type: Review

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  39. Chemical pleurodesis is widely recommended in the treatment of pulmonary air leak of different etiologies as well as malignant pleural effusions and chylothorax. Conventional chemical pleurodesis using erythro...

    Authors: Suk Ju Cho, Su Wan Kim and Jee Won Chang

    Citation: Multidisciplinary Respiratory Medicine 2014 9:61

    Content type: Case report

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  40. Acute pneumonia is a serious problem in the elderly and various risk factors have already been reported, but the involvement of QTc interval prolongation remains uncertain. The aim of this study was to elucida...

    Authors: Yasuyuki Taooka, Gen Takezawa, Miki Ohe, Akihisa Sutani and Takeshi Isobe

    Citation: Multidisciplinary Respiratory Medicine 2014 9:59

    Content type: Original research article

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