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  1. Withholding or withdrawing a life-sustaining treatment tends to be very challenging for health care providers, patients, and their family members alike. When a patient’s life seems to be nearing its end, it is...

    Authors: Jos VM Welie and Henk AMJ ten Have

    Citation: Multidisciplinary Respiratory Medicine 2014 9:14

    Content type: State of the art

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  2. To evaluate and compare the diagnostic efficiency of serum (s) and pleural (p) levels of adenosine deaminase (ADA)-1, ADA-2, total ADA, and interferon-gamma (IFN-γ) for the differential diagnosis of pleural tu...

    Authors: Sibel Yurt, Canan Küçükergin, Burcu Arpinar Yigitbas, Şule Seçkin, Hüseyin Cem Tigin and Ayşe Filiz Koşar

    Citation: Multidisciplinary Respiratory Medicine 2014 9:12

    Content type: Original research article

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  3. The mean platelet volume (MPV) reflects the size of platelets. It has been shown to be inversely correlated with level of the inflammation in some chronic inflammatory diseases. This prospective study aims to ...

    Authors: Gulsah Gunluoglu, Esra Ertan Yazar, Nurdan Simsek Veske, Ekrem Cengiz Seyhan and Sedat Altin

    Citation: Multidisciplinary Respiratory Medicine 2014 9:11

    Content type: Original research article

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  4. Chlamydia psittaci (Cp) is a respiratory pathogen capable of inducing acute pulmonary zoonotic disease (psittacosis) or persistent infection. To elucidate the pathogenesis of this infection, a translational large...

    Authors: Carola Ostermann, Susanna Linde, Christiane Siegling-Vlitakis and Petra Reinhold

    Citation: Multidisciplinary Respiratory Medicine 2014 9:10

    Content type: Original research article

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    The Erratum to this article has been published in Multidisciplinary Respiratory Medicine 2014 9:42

  5. Pharmacologic therapies have an important role in the success of interventions for smoking cessation. This study aims to determine the efficacy of several pharmacologic treatments in patients who applied to a ...

    Authors: Elif Yilmazel Ucar, Omer Araz, Nafiye Yilmaz, Metin Akgun, Mehmet Meral, Hasan Kaynar and Leyla Saglam

    Citation: Multidisciplinary Respiratory Medicine 2014 9:9

    Content type: Original research article

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  6. The safety of beta-blockers as a heart rate-limiting drug (HRLD) in patients with acute respiratory failure (ARF) due to chronic obstructive lung disease (COPD) has not been properly assessed in the intensive ...

    Authors: Feyza Kargin, Huriye Berk Takir, Cuneyt Salturk, Nezihe Ciftaslan Goksenoglu, Can Yucel Karabay, Ozlem Yazicioglu Mocin, Nalan Adiguzel, Gokay Gungor, Merih Kalamanoglu Balci, Murat Yalcinsoy, Ramazan Kargin and Zuhal Karakurt

    Citation: Multidisciplinary Respiratory Medicine 2014 9:8

    Content type: Original research article

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  7. Chronic obstructive pulmonary disease (COPD) is a major cause of acute hospital admissions. The main object of our study was to evaluate the effects of telemedicine video-consultation (TVC) on the frequency of...

    Authors: Safaa Saleh, Jan Petter Larsen, Johannes Bergsåker-Aspøy and Heidi Grundt

    Citation: Multidisciplinary Respiratory Medicine 2014 9:6

    Content type: Original research article

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  8. The editors of Multidisciplinary Respiratory Medicine would like to thank all of our reviewers who have contributed to the journal in Volume 8 (2013).

    Authors: Fernando De Benedetto, Claudio F Donner and Claudio M Sanguinetti

    Citation: Multidisciplinary Respiratory Medicine 2014 9:4

    Content type: Reviewer acknowledgement

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  9. Some peptides, which regulate the metabolic balance, are thought to play important roles in nutritional disorders and systemic inflammation in COPD. Treatment of rats with obestatin decreased body-weight gain....

    Authors: Yi Lei, Yasha Liang, Yifan Chen, Xiaojing Liu, Xiaoyang Liao and Fengming Luo

    Citation: Multidisciplinary Respiratory Medicine 2014 9:5

    Content type: Original research article

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  10. Extravascular lung water (EVLW) is a sensitive prognostic indicator of pulmonary edema. Thus, EVLW may be an advantageous method of fluid management. This study aims to evaluate the outcomes of using EVLW and ...

    Authors: Wei Hu, Chang-Wen Lin, Bing-Wei Liu, Wei-Hang Hu and Ying Zhu

    Citation: Multidisciplinary Respiratory Medicine 2014 9:3

    Content type: Original research article

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  11. The distribution of allergens may vary with different geographic areas, suggesting the importance of local epidemiological data to support evidence-based prevention and management of allergic diseases. We inve...

    Authors: Bao-qing Sun, Pei-yan Zheng, Xiao-wen Zhang, Hui-min Huang, De-hui Chen and Guang-qiao Zeng

    Citation: Multidisciplinary Respiratory Medicine 2014 9:2

    Content type: Original research article

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  12. Aspergillus infection was mostly reported with high mortality rates and a bad prognosis in immunocompromised patients, but data were lacking on the clinical characteristics of aspergillus infection in liver cirrh...

    Authors: Jiajia Chen, Qing Yang, Jianrong Huang and Lanjuan Li

    Citation: Multidisciplinary Respiratory Medicine 2014 9:1

    Content type: Original research article

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  13. The diagnosis of pulmonary embolism (PE) is frequently considered in patients presenting to the emergency department or when hospitalized. Although early treatment is highly effective, PE is underdiagnosed and...

    Authors: Federico Lavorini, Vitantonio Di Bello, Maria Luisa De Rimini, Giovanni Lucignani, Letizia Marconi, Gualtiero Palareti, Raffaele Pesavento, Domenico Prisco, Massimo Santini, Nicola Sverzellati, Antonio Palla and Massimo Pistolesi

    Citation: Multidisciplinary Respiratory Medicine 2013 8:75

    Content type: Review

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  14. Different medical therapies are employed in acute lung injury (ALI) but there is still a debate about the efficacy of these drugs. Among these therapies steroids are clinically applied and bosentan is experime...

    Authors: Omer Araz, Elif Demirci, Elif Yilmazel Ucar, Muhammet Calik, Didem Pulur, Adem Karaman, Muhammed Yayla, Eren Altun, Zekai Halici and Metin Akgun

    Citation: Multidisciplinary Respiratory Medicine 2013 8:74

    Content type: Original research article

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  15. It can be difficult to perform CT guided biopsy of small pulmonary nodules especially if the position is behind a costa or close to the diaphragm and respiratory movements may hamper the procedure. During apne...

    Authors: Benedict Kjaergaard, Peter R Zepernick, Annette Bergmann, Henrik K Jensen, Milka Mladenovic and Bodil S Rasmussen

    Citation: Multidisciplinary Respiratory Medicine 2013 8:73

    Content type: Case report

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  16. Pulmonary Hypertension (PH) associated to chronic respiratory diseases is currently classified in the 3rd group, as a mild to moderate form of pre-capillary PH that progressively complicates the prognosis of asso...

    Authors: Lucio Casali, Pierluigi Carratù and Matteo Sofia

    Citation: Multidisciplinary Respiratory Medicine 2013 8:72

    Content type: Review

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  17. Indoor air pollution (IAP) constitutes a major global public health problem requiring increasing efforts in research and policymaking that may have special significance for elderly that are likely to spend mos...

    Authors: Isabella Annesi-Maesano, Dan Norback, Jan Zielinski, Alfred Bernard, Cristina Gratziou, Torben Sigsgaard, Piersante Sestini and Giovanni Viegi

    Citation: Multidisciplinary Respiratory Medicine 2013 8:71

    Content type: Short report

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  18. Despite the gradual improvement in treatment procedures and cure rates of acromegaly, a steady increase in the mortality rate due to respiratory disease has been documented in recent decades. In this study, ou...

    Authors: Gustavo Bittencourt Camilo, Fernando Silva Guimarães, Débora Pedroza Guedes Silva, Roberto Mogami, Leandro Kasuki, Mônica Roberto Gadelha, Pedro Lopes Melo and Agnaldo José Lopes

    Citation: Multidisciplinary Respiratory Medicine 2013 8:70

    Content type: Original research article

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  19. Non-small cell lung cancer (NSCLC) accounts for approximately 80% of new diagnoses of pulmonary carcinoma. This study investigated the correlation between 18 F-fluorodeoxyglucose uptake in computerized tomogra...

    Authors: Mehmet Akif Özgül, Gamze Kirkil, Ekrem Cengiz Seyhan, Erdoğan Çetinkaya, Güler Özgül and Mahmut Yüksel

    Citation: Multidisciplinary Respiratory Medicine 2013 8:69

    Content type: Original research article

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  20. Guidelines advise annual influenza vaccination in chronic asthma. The aim of this study was to determine uptake of the influenza vaccine in a group of patients (n = 146) with moderate to severe chronic asthma ...

    Authors: Rachelle Asciak, Martin Balzan and Jesmar Buttigieg

    Citation: Multidisciplinary Respiratory Medicine 2013 8:68

    Content type: Original research article

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  21. Oxytocin (Sintocynon) is considered an uncommon cause of severe allergic reactions during delivery. We have recently shown that allergic sensitization to latex might constitute an important predisposing risk f...

    Authors: Gennaro Liccardi, Maria Beatrice Bilò, Ciro Mauro, Antonello Salzillo, Amedeo Piccolo, Maria D’Amato, Annabella Liccardi and Gennaro D’Amato

    Citation: Multidisciplinary Respiratory Medicine 2013 8:67

    Content type: Commentary

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  22. The prevalence of sexual dysfunction in patients with COPD is high and its significance has not been sufficiently stressed. The aim of this study is to investigate the incidence of erectile dysfunction (ED) an...

    Authors: Hasan Kahraman, Bilal Sen, Nurhan Koksal, Metin Kilinç and Sefa Resim

    Citation: Multidisciplinary Respiratory Medicine 2013 8:66

    Content type: Original research article

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  23. Lung cancer is the leading cause of death among cancers in the world. The annual death toll due to this disease exceeds the combined deaths caused by colon, breast, prostate, and pancreatic cancers. As a resul...

    Authors: Feridoun Karimi-Busheri, Aghdass Rasouli-Nia, Victoria Zadorozhny and Habib Fakhrai

    Citation: Multidisciplinary Respiratory Medicine 2013 8:65

    Content type: Original research article

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  24. Frequent exacerbations of chronic obstructive pulmonary disease (COPD) have negative effects on quality of life and survival. Thus, factors related to exacerbations should be determined. We aimed to evaluate t...

    Authors: Sevinc Sarinc Ulasli, Serife Savas Bozbas, Zeynep Erayman Ozen, Berna Akinci Ozyurek and Gaye Ulubay

    Citation: Multidisciplinary Respiratory Medicine 2013 8:64

    Content type: Original research article

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  25. The purpose of the study was to determine the relationship between high sensitivity C-reactive protein (hs-CRP) levels and prognostic factors in chronic obstructive pulmonary disease.

    Authors: Reshu Agarwal, Mohammad Shoaib Zaheer, Zubair Ahmad and Jamal Akhtar

    Citation: Multidisciplinary Respiratory Medicine 2013 8:63

    Content type: Original research article

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  26. Appetite-modulating hormones ghrelin and leptin might be relevant to asthma with their pro-inflammatory effects, and calprotectin has been recognized as a promising marker of inflammation. The purpose of this ...

    Authors: Nazan Cobanoglu, Nilufer Galip, Ceyhun Dalkan and Nerin Nadir Bahceciler

    Citation: Multidisciplinary Respiratory Medicine 2013 8:62

    Content type: Original research article

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  27. The aim of this study is to investigate the prevalence of metabolic syndrome (MetS), carotid intima media thickness (IMT), and serum C-reactive protein (CRP) levels in patients with chronic obstructive pulmona...

    Authors: Aylin Ozgen Alpaydin, Isin Konyar Arslan, Selim Serter, Aysin Sakar Coskun, Pinar Celik, Fatma Taneli and Arzu Yorgancioglu

    Citation: Multidisciplinary Respiratory Medicine 2013 8:61

    Content type: Original research article

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  28. Literature is still arguing about a possible relationship between airway hyperresponsiveness (AHR) and body mass index (BMI). This study aimed at evaluating the influence of BMI on AHR and pulmonary function i...

    Authors: Bruno Sposato, Marco Scalese, Maria Giovanna Migliorini, Maria Piera Riccardi, Massimo Tosti Balducci, Luigi Petruzzelli and Raffaele Scala

    Citation: Multidisciplinary Respiratory Medicine 2013 8:60

    Content type: Original research article

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  29. Invasive pulmonary aspergillosis (IPA) is an infection often occurring in neutropenic patients and has high mortality rates. In recent years, it has been reported that the incidence of IPA has also increased i...

    Authors: Nuri Tutar, Gokhan Metan, Ayşe Nedret Koç, Insu Yilmaz, Ilkay Bozkurt, Zuhal Ozer Simsek, Hakan Buyukoglan, Asiye Kanbay, Fatma Sema Oymak, Inci Gulmez and Ramazan Demir

    Citation: Multidisciplinary Respiratory Medicine 2013 8:59

    Content type: Original research article

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  30. Cardiovascular disease (CVD) is a common comorbidity in patients with chronic airway obstruction, and is associated with systemic inflammation and airway obstruction. The aim of this study was to evaluate the ...

    Authors: Michela Bellocchia, Monica Masoero, Antonio Ciuffreda, Silvia Croce, Arianna Vaudano, Roberto Torchio, Monica Boita and Caterina Bucca

    Citation: Multidisciplinary Respiratory Medicine 2013 8:58

    Content type: Original research article

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  31. Valid sarcoidosis incidence assessment is contingent on access to medical care, thoroughness of reportage, assiduity of radiographic interpretation, employment and health care screening policies, misclassifica...

    Authors: Jerome M Reich

    Citation: Multidisciplinary Respiratory Medicine 2013 8:57

    Content type: Commentary

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  32. Incidental thyroid nodules (ITNs) are defined as newly encountered nodules identified on imaging performed for an unrelated purpose. In practice, ITNs are often detected on chest computed tomography (CT). We i...

    Authors: Jong Hoo Lee, Sun Young Jeong and Yee Hyung Kim

    Citation: Multidisciplinary Respiratory Medicine 2013 8:56

    Content type: Original research article

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  33. Chest ultrasonography can be a useful diagnostic tool for respiratory physicians. It can be used to complete and widen the general objective examination also in emergency situations, at the patient’s bedside. ...

    Authors: Andrea Smargiassi, Riccardo Inchingolo, Gino Soldati, Roberto Copetti, Giampietro Marchetti, Alessandro Zanforlin, Rosangela Giannuzzi, Americo Testa, Stefano Nardini and Salvatore Valente

    Citation: Multidisciplinary Respiratory Medicine 2013 8:55

    Content type: Review

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  34. Chest ultrasonography can be a useful diagnostic tool for respiratory physicians. It can be used to complete and widen the general objective examination also in emergency situations, at the patient’s bedside. ...

    Authors: Alessandro Zanforlin, Rosangela Giannuzzi, Stefano Nardini, Americo Testa, Gino Soldati, Roberto Copetti, Giampietro Marchetti, Salvatore Valente, Riccardo Inchingolo and Andrea Smargiassi

    Citation: Multidisciplinary Respiratory Medicine 2013 8:54

    Content type: Review

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  35. Idiopathic pulmonary fibrosis (IPF), a chronic fibrosing lung disease of a progressive nature and unknown etiology, has the largest epidemiological impact and the worst prognosis among the idiopathic interstit...

    Authors: Gaetano Cicchitto and Claudio M Sanguinetti

    Citation: Multidisciplinary Respiratory Medicine 2013 8:53

    Content type: Review

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  36. Mount Etna, located in the eastern part of Sicily (Italy), is the highest and most active volcano in Europe. During the sustained eruption that occurred in October-November 2002 huge amounts of volcanic ash fe...

    Authors: Daniele Lombardo, Nicola Ciancio, Raffaele Campisi, Annalisa Di Maria, Laura Bivona, Venerino Poletti, Antonio Mistretta, Annibale Biggeri and Giuseppe Di Maria

    Citation: Multidisciplinary Respiratory Medicine 2013 8:51

    Content type: Original research article

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  37. Asthma is considered an heterogeneous disease, requiring multiple biomarkers for diagnosis and management. Fractional exhaled nitric oxide in exhaled breath (FeNO) was the first useful non-invasive marker of a...

    Authors: Giuliana Ferrante, Velia Malizia, Roberta Antona, Giovanni Corsello and Stefania La Grutta

    Citation: Multidisciplinary Respiratory Medicine 2013 8:50

    Content type: Review

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  38. The role of biomarkers for prognostication and diagnosis of pulmonary embolism (PE) is increasing. It has been reported that pregnancy-associated plasma protein-A (PAPP-A) can be used as a proatherosclerotic m...

    Authors: Serdar Berk, Omer Tamer Dogan, Eylem Itir Aydemir, Asli Bingol, Sefa Levent Ozsahin and Ibrahim Akkurt

    Citation: Multidisciplinary Respiratory Medicine 2013 8:49

    Content type: Original research article

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  39. Achieving asthma control is a major challenge in children, otherwise symptoms perception remain poor especially at this age. The aim of this study is to evaluate the relationship between Asthma Control Test (ACTT...

    Authors: Daniele Rapino, Marina Attanasi, Nicola P Consilvio, Alessandra Scaparrotta, Anna Cingolani, Marzia Cerasa, Angelika Mohn, Sabrina Di Pillo and Francesco Chiarelli

    Citation: Multidisciplinary Respiratory Medicine 2013 8:48

    Content type: Original research article

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  40. A high rate of response to treatment with epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) has been observed in certain patients (women, of East Asian ethnicity, with non-smoking history a...

    Authors: Yasuhiro Sakai, Takashi Yamasaki, Yoshito Kusakabe, Daisuke Kasai, Yoshikazu Kotani, Yoshihiro Nishimura and Tomoo Itoh

    Citation: Multidisciplinary Respiratory Medicine 2013 8:47

    Content type: Case report

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  41. The aim of this study was to analyze and describe the epidemiological characteristics and trends of lung cancer in North Sardinia, Italy, in the period 1992–2010.

    Authors: Panagiotis Paliogiannis, Federico Attene, Antonio Cossu, Mario Budroni, Rosaria Cesaraccio, Francesco Tanda, Mario Trignano and Giuseppe Palmieri

    Citation: Multidisciplinary Respiratory Medicine 2013 8:45

    Content type: Original research article

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  42. Expiratory CT scan is usually obtained as supplement to normal inspiratory CT scan to recognize air-trapping, which is expression of small airways obstruction. In some patients the air-trapping may be the only...

    Authors: Michele Gaeta, Fabio Minutoli, Giuseppe Girbino, Alessandra Murabito, Caterina Benedetto, Rosario Contiguglia, Paolo Ruggeri and Salvatore Privitera

    Citation: Multidisciplinary Respiratory Medicine 2013 8:44

    Content type: Review

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  43. Chronic obstructive pulmonary disease (COPD) is an important public health issue in many countries which is estimated to become the fifth cause of disability and the third cause of mortality in the world withi...

    Authors: Júlio César Mendes de Oliveira, Isabella de Carvalho Aguiar, Ana Carolina Negrinho de Oliveira Beloto, Israel Reis Santos, Fernando Sergio Studart Leitão Filho, Luciana M Malosa Sampaio, Claudio F Donner and Luís Vicente Franco de Oliveira

    Citation: Multidisciplinary Respiratory Medicine 2013 8:43

    Content type: Original article

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  44. Herpes simplex virus (HSV) has been shown to cause respiratory tract infections mostly in severely immunocompromised patients. Endobronchial tumor-like lesions have been described very rarely as HSV pulmonary ...

    Authors: Stamatis Katsenos, Dimitrios Sampaziotis and Stavros Archondakis

    Citation: Multidisciplinary Respiratory Medicine 2013 8:42

    Content type: Case report

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  45. The presence of anxiety and depressive symptoms in COPD patients has beenacknowledged for many years. The preponderance of recent studies supportsthe utility of pulmonary rehabilitation programs to reduce the ...

    Authors: Athanasios Tselebis, Dionisios Bratis, Argiro Pachi, Georgios Moussas, Ioannis Ilias, Maria Harikiopoulou, Elpida Theodorakopoulou, Silvia Dumitru, Epaminondas Kosmas, Alexandros Vgontzas, Nikolaos Siafakas and Nikolaos Tzanakis

    Citation: Multidisciplinary Respiratory Medicine 2013 8:41

    Content type: Original research article

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  46. The protein-calorie malnutrition, resulting in muscle mass loss, frequently occurs in severe COPD patients with chronic respiratory failure (CRF), causing dyspnea, reduced exercise tolerance and impaired quali...

    Authors: Stefano Marinari, Maria Rosaria Manigrasso and Fernando De Benedetto

    Citation: Multidisciplinary Respiratory Medicine 2013 8:40

    Content type: Original research article

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