Articles

Bronchial cast hiding a lung cancer

A 70-year-old man was admitted for severe hypoxia, haemoptysis and cough. Chest-X-ray and CT-scan indicated a right-lower-lobe collapse. Bronchoscopy showed its occlusion by whitish dense mucus. Aspiration rev...

Authors: Marcello Migliore, Nicola Ciancio, Riccardo Giuliano and Giuseppe Di Maria

Idiopathic pulmonary fibrosis: diagnostic pitfalls and therapeutic challenges

Idiopathic pulmonary fibrosis (IPF), the most common of the idiopathic interstitial pneumonias, is a devastating condition that carries a prognosis worse than that of many cancers. As such, it represents one o...

Authors: Paolo Spagnolo, Roberto Tonelli, Elisabetta Cocconcelli, Alessandro Stefani and Luca Richeldi

Nintedanib (BIBF 1120) for IPF: a tomorrow therapy?

Idiopathic pulmonary fibrosis is a rare, life threatening disease characterized by an anarchic fibrogenesis, limited survival and few therapeutic options. Its pathogenesis is complex and involves the interacti...

Authors: Sabina A Antoniu

Dieulafoy’s disease of the bronchus: a possible mistake

We present a case of a 57 year old woman who suffered from massive hemoptysis; she was sent to our Department for a suspect neoformant lesion. We assumed it might be a Dielafoy’s disease and proceeded with an ...

Authors: Emanuela E Barisione, Gabriele G Ferretti, Silvia S Ravera and Mario M Salio

Chronic obstructive pulmonary disease phenotype desaturator with hypoxic vascular remodelling and pulmonary hypertension obtained by cluster analysis

Significant heterogeneity of clinical presentation and disease progression exists within chronic obstructive pulmonary disease (COPD). This article discusses and refines the concept of desaturator phenotypes i...

Authors: Domenico Maurizio Toraldo, Mauro Minelli, Francesco De Nuccio and Giuseppe Nicolardi

Prominent features of platelet count, plateletcrit, mean platelet volume and platelet distribution width in pulmonary tuberculosis

We aimed to investigate the relation of platelet count (PLT) and plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) with other acute phase reactants and radiological extent in...

Authors: Füsun Şahin, Esra Yazar and Pınar Yıldız

Right sided arcus aorta as a cause of dyspnea and chronic cough

Right sided arcus aorta (RSAA) is a rare condition that is usually asymptomatic. Patients may present with exertional dyspnea and chronic cough. A recent article suggested that RSAA should be included in the d...

Authors: Sevket Ozkaya, Bilal Sengul, Semra Hamsici, Serhat Findik, Unal Sahin, Aziz Gumus and Halit Cinarka

Bilateral pulmonary sequestration in the elderly adult

Pulmonary sequestration (PS) is a rare malformation consisting of aberrant lung tissue which is not affiliated with the normal bronchial system and is fed by an aberrant artery that derives from systemic arter...

Authors: Ersin Sukru Erden, Hanifi Bayarogullari, Hatice Bilgic, Tulin Yetim and Eyup Buyukkaya

Endobronchial Tubercolosis: a peculiar feature of TB often underdiagnosed

Authors: Lucio Casali and Mariano E Crapa

Endobronchial tuberculosis: histopathological subsets and microbiological results

Endobronchial tuberculosis (EBTB) is defined as a tuberculous infection of the tracheobronchial tree with microbial and histopathological evidence, with or without parenchymal involvement. Bronchoscopic appear...

Authors: Sevket Ozkaya, Salih Bilgin, Serhat Findik, Hayriye Çete Kök, Canan Yuksel and Atilla Güven Atıcı

In situ thrombosis in pulmonary arterial aneurysms due to Behçet’s disease and efficacy of ımmunosuppressive therapy

BehçetDisease (BD) is a systemic vasculitis characterized by recurrent oral and genital ulcers and uveitis, arthritis, and involvement of the gastrointestinal tract, central nervous system and blood vessels. T...

Authors: Sevket Ozkaya, Unal Sahin, Aziz Gumus, Filiz Taşçı, Halit Çınarka and Asiye Yavuz

Factors associated with health-related quality of life in adults with asthma. A cross-sectional study

The measurement of health-related quality of life (HRQoL) is increasingly recognized as an important endpoint, as a reflection of the effects of the disease from a patient perspective. Our aim was to evaluate ...

Authors: Francisco-Javier Gonzalez-Barcala, Ramon de la Fuente-Cid, Mónica Tafalla, Javier Nuevo and Francisco Caamaño-Isorna

Flexible bronchoscopy may decrease respiratory muscle strength: premedicational midazolam in focus

Flexible bronchoscopy (FB) is a procedure accepted to be safe in general, with low complication rates reported. On the other hand, it is known that patients with pre-existing respiratory failure have developed hy...

Authors: Baykal Tulek, Fikret Kanat, Sule Tol and Mecit Suerdem

Management of kyphoscoliosis patients with respiratory failure in the intensive care unit and during long term follow up

We aimed to evaluate the ICU management and long-term outcomes of kyphoscoliosis patients with respiratory failure.

Authors: Nalan Adıgüzel, Zuhal Karakurt, Gökay Güngör, ÖzlemYazıcıoğlu Moçin, Merih Balcı, Cüneyt Saltürk, Feyza Kargın, Huriye Berk Takır, Ayşem Güven and Tülay Yarkın

Prognostic value of p53 and Ki67 expression in fiberoptic bronchial biopsies of patients with non small cell lung cancer

Overexpression of the tumor suppressor gene p53 and the marker for cellular proliferation Ki67 in open lung biopsies are indicated as predictor factors of survival of patients with lung cancer. However, the pr...

Authors: Nicola Ciancio, Maria Grazia Galasso, Raffaele Campisi, Laura Bivona, Marcello Migliore and Giuseppe U Di Maria

Anti-reflux procedure for difficult-to-treat asthmatic children, case report and literature review

Gastroesophageal reflux disease (GERD) is a commonly encountered condition in children, which at times causes respiratory distress, such as asthmatic symptoms, and results in serious morbidity and even mortali...

Authors: Zhi-Wei Hu, Zhong-Gao Wang, Ji-Min Wu and Song-Tao Tan

Multiplanar and two-dimensional imaging of central airway stenting with multidetector computed tomography

Multidetector computed tomography (MDCT) provides guidance for primary screening of the central airways. The aim of our study was assessing the contribution of multidetector computed tomography- two dimensiona...

Authors: Mehmet Akif Ozgul, Guler Ozgul, Erdogan Cetinkaya, Yasin Abul, Gamze Kirkil, Ekrem Cengiz Seyhan, Emine Kamiloglu and Sule Gul

Iatrogenic Cushing’s syndrome with inhaled steroid plus antidepressant drugs

Current guidelines recommend the use of inhaled corticosteroids (ICS) for suppression of airway inflammation in patients with asthma. Although it is well known that ICS cause dose-related adrenocortical suppre...

Authors: Ozlem Celik, Mutlu Niyazoglu, Hikmet Soylu and Pinar Kadioglu

Aspiration of tracheoesophageal prosthesis in a laryngectomized patient

The voice prosthesis inserted into a tracheoesophageal fistula has become the most widely used device for voice rehabilitation in patients with total laryngectomy.

Authors: Sergio C Conte, Elena De Nardi, Federico Conte and Stefano Nardini

Factors related to under-diagnosis and under-treatment of childhood asthma in metropolitan France

Under-diagnosis and under-treatment of childhood asthma were investigated in France using data collected during the 6 Cities Study, the French contribution to the International Study of Asthma and Allergies in...

Authors: Isabella Annesi-Maesano, Carla Sterlin, Denis Caillaud, Fréderic de Blay, François Lavaud, Denis Charpin and Chantal Raherisson

Reasons for inadequate asthma control in children: an important contribution from the “French 6 Cities Study”

Authors: Giuliana Ferrante and Stefania La Grutta

Intensive long-term pulmonary rehabilitation program after oesophagectomy, a reflection

Authors: Franco Pasqua

Rationale and clinical benefits of an intensive long-term pulmonary rehabilitation program after oesophagectomy: preliminary report

Patients who undergo oesophagectomy for oesophagealcancer (OC) usually have an overall poor prognosis and, still more preoccupying, an unsatisfactory quality of life (QoL). Considering that, as already noted, ...

Authors: Filippo Lococo, Alfredo Cesario, Silvia Sterzi, Giovanni Magrone, Valentina Dall’Armi, Francesca Mattei, Francesco Varone, Venanzio Porziella, Stefano Margaritora and Pierluigi Granone

Imaging of central airway stenting with multidetector computed tomography

Authors: Giovacchino Pedicelli

Can high-quality palliative care for respiratory patients be improved?

Authors: Nicolino Ambrosino

How do patients die in a rehabilitative unit dedicated to advanced respiratory diseases?

Evidences on how in-hospital COPD patients are cared in a Rehabilitative Respiratory Unit during the last time before death are lacking. This observational study was aimed at 1. analyzing the characteristics o...

Authors: Michele Vitacca and Laura Comini

Analysis of two cases with bronchopulmonary neurofibromatosis

Neurogenic tumor of lung is very rare. Only few cases have been reported in the literature. We present here two cases of bronchopulmonary neurofibromatosis in two adults. In both cases, attempts at imaging fai...

Authors: Ting Yuan, Bai-ling Luo, Qi-hua Gu and Ji Yao

Perspective on long term oxygen therapy

Authors: Peter Howard

Changes in blood hemoglobin and blood gases PaO₂ and PaCO₂ in severe COPD overa three-year telemonitored program of long-term oxygen treatment

Information on the effects of long-term oxygen treatment (LTOT) on blood hemoglobin (Hb) in severe COPD are limited. The aim was to assess blood Hb values in severe COPD, and investigate the time-course of bot...

Authors: Roberto W Dal Negro, Silvia Tognella, Luca Bonadiman and Paola Turco

Propylthiouracil-induced lupus-like or vasculitis syndrome

A 27 year old female with Graves’ disease presented with fever, exertional dyspnea and polyarthralgia. Erythema nodosum had occured three months earlier. The patient declared irregular use of propylthiouracil ...

Authors: Cuneyt Tetikkurt, Mehmet Yuruyen, Seza Tetikkurt, Nihal Bayar and Imran Ozdemir

Montelukast versus inhaled corticosteroids in the management of pediatric mild persistent asthma

International guidelines recommend the use of inhaled corticosteroids (ICSs) as the preferred therapy, with leukotriene receptor antagonists (LTRAs) as an alternative, for the management of persistent asthma i...

Authors: Alessandra Scaparrotta, Sabrina Di Pillo, Marina Attanasi, Daniele Rapino, Anna Cingolani, Nicola Pietro Consilvio, Marcello Verini and Francesco Chiarelli

Evaluation of pharmacotherapy of obstructive airway diseases in the Montenegrin outpatient care: comparison with two Scandinavian countries

This study is aimed at evaluating the pharmacotherapy of obstructive airway diseases (OAD) in the Montenegrin outpatient care (MOC) in 2010.

Authors: Natasha Duborija-Kovacevic and Milica Martinovic

The sarcoid granuloma: ‘epithelioid’ or ‘lymphocytic-epithelioid’ granuloma?

This study aims to analyze the structure and quantities of cellular elements in sarcoid granulomas.

Authors: Zdravko Kosjerina, Bojan Zaric, Dejan Vuckovic, Dusan Lalosevic, Goran Djenadic and Bruno Murer

Pulmonary function tests and rehabilitation in 2012: beyond sitting position

Authors: Federica Gamna and Roberto Torchio

Effects of breathing maneuver and sitting posture on muscle activity in inspiratory accessory muscles in patients with chronic obstructive pulmonary disease

To determine the influence of breathing maneuver and sitting posture on tidal volume (TV), respiratory rate (RR), and muscle activity of the inspiratory accessory muscles in patients with chronic obstructive p...

Authors: Ki-song Kim, Min-kwang Byun, Won-hwee Lee, Heon-seock Cynn, Oh-yun Kwon and Chung-hwi Yi

The overlap phenotype: the (missing) link between asthma and COPD

Authors: Barbara Piras and Marc Miravitlles

The need to further understand who gets hospitalized for a COPD exacerbation

Authors: Diego J Maselli and Antonio Anzueto

Factors associated with hospital admission in patients reaching the emergency department with COPD exacerbation

The aim of this study was to determine the frequency of COPD exacerbations in our Emergency Department, as well as the hospitalization-related factors.

Authors: Maria Teresa García-Sanz, Carlos Pol-Balado, Concepción Abellás, Juan Carlos Cánive-Gómez, Diana Antón-Sanmartin and Francisco J González-Barcala

Anatomy and neuro-pathophysiology of the cough reflex arc

Coughing is an important defensive reflex that occurs through the stimulation of a complex reflex arc. It accounts for a significant number of consultations both at the level of general practitioner and of res...

Authors: Mario Polverino, Francesca Polverino, Marco Fasolino, Filippo Andò, Antonio Alfieri and Francesco De Blasio

Pulmonary alveolar proteinosis: diagnostic and therapeutic challenges

Pulmonary Alveolar Proteinosis (PAP) is a rare syndrome characterized by pulmonary surfactant accumulation within the alveolar spaces. It occurs with a reported prevalence of 0.1 per 100,000 individuals and in...

Authors: Ilaria Campo, Zamir Kadija, Francesca Mariani, Elena Paracchini, Giuseppe Rodi, Francesco Mojoli, Antonio Braschi and Maurizio Luisetti

Extrapulmonary features of bronchiectasis: muscle function, exercise capacity, fatigue, and health status

There are limited number of studies investigating extrapulmonary manifestations of bronchiectasis. The purpose of this study was to compare peripheral muscle function, exercise capacity, fatigue, and health st...

Authors: Ozge Ozalp, Deniz Inal-Ince, Ebru Calik, Naciye Vardar-Yagli, Melda Saglam, Sema Savci, Hulya Arikan, Meral Bosnak-Guclu and Lutfi Coplu

Non-HIV Pneumocystis pneumonia: do conventional community-acquired pneumonia guidelines under estimate its severity?

Non-HIV Pneumocystis pneumonia (PCP) can occur in immunosuppressed patients having malignancy or on immunosuppressive agents. To classify severity, the A-DROP scale proposed by the Japanese Respiratory Society (J...

Authors: Nobuhiro Asai, Shinji Motojima, Yoshihiro Ohkuni, Ryo Matsunuma, Kei Nakasima, Takuya Iwasaki, Tamao Nakashita, Yoshihito Otsuka and Norihiro Kaneko

Rationale for the Turin Conference/Congress 2012

Authors: Claudio F Donner and Carlo Gulotta

Cervical necrotizing fasciitis associated with descending necrotizing mediastinitis

We report a case of potentially fatal cervical necrotizing fasciitis and descending necrotizing mediastinitis due to deep neck infection in a 66-year-old male patient with no history or evidence of immunocompr...

Authors: Ugur Gonlugur, Oguz Guclu, Ozan Karatag, Arzu Mirici and Sefa Derekoy

Frequency of pleural effusion in acute bronchiolitis and its effect on prognosis

To analyze the frequency of pleural effusion and the effect on prognosis in children with acute bronchiolitis.

Authors: Ayse E. Yilmaz, Aslı Koktener, Nurullah Celik, Halise Akca, Meki Bilici and Emin Mete

Chronic ingestion of alcohol modulates expression of ubiquitin editing enzyme A20 in lung macrophages

Alcohol abuse is involved in the pathogenesis of multiple organ disorders; the underlying mechanism is incompletely understood. The ubiquitin editing enzyme A20 is involved in regulating activities in the cell...

Authors: Quan-Yong Huang, Yu-Chuan Chen and Shui-Ping Liu

Effects of indoor air pollution on respiratory symptoms of non-smoking women in Niš, Serbia

The aim of this study was to determine the effects of indoor air pollution exposure on respiratory symptoms and illnesses in non-smoking women in Niš, Serbia.

Authors: Aleksandra Stanković, Maja Nikolić and Mirjana Arandjelović

The European Respiratory Roadmap

Authors: Marc Decramer

Does the asthma control test reflect inflammation?

Authors: Margherita Neri

Chronic pulmonary aspergilloses: do they exist?

Authors: Gianfranco Schiraldi and Lucia Minniti