From: Sedation in non-invasive ventilation: do we know what to do (and why)?
Study | No. of patients | Patient characteristics | Experimental NIV strategy | Sedation status |
---|---|---|---|---|
Hill et al. 2000 [4] | 21 | ARF | VPAP in ST-A mode | Sedation protocol reportedly used. Study published as abstract only |
Nava et al. 1998 [5] | 50 | Exacerbation of COPD; mechanical ventilation for at least 36–48 h | Non-invasive pressure support on conventional ventilator delivered with face mask | Sedation reportedly used during NIV but apparently not protocolized or defined |
Prasad et al. 2009 [6] | 30 | COPD; AHRF | Bilevel NIV (pressure mode) delivered by full face mask | Patients received neuromuscular blocking drugs and sedatives in immediately preceding phase of invasive ventilation. Use of sedation during NIV not clear |
Rabie Agmy et al. 2004 [7] | 37 | Exacerbation of COPD | Proportional-assist NIV in timed mode, delivered by face or nasal mask | Patients received neuromuscular blocking drugs and sedatives in immediately preceding phase of invasive ventilation. Use of sedation during NIV not clear |
Vaschetto et al. 2012 [8] | 20 | Hypoxaemic respiratory failure; invasive mechanical ventilation for at least 48Â h | Helmet NIV | Sedation reportedly used during NIV but apparently not protocolized or defined. Rates of continuous sedation during NIV reported to be similar in both groups (a priori study outcome) |