New Thematic Series: Obstructive Sleep Apnoea Syndrome
Obstructive sleep apnea syndrome (OSAS) is an an underdiagnosed chronic disease characterized by recurrent episodes of apneas and hypopneas during sleep, associated with repetitive episodes of intermittent hypoxemia, intrathoracic pressure changes, arousals, and excessive daytime sleepiness. OSAS is considered as risk factor for cancer. Patients with untreated OSAS are at significantly increased risk of cardiovascular, metabolic, neurocognitive disease and motor vehicle accidents (MVAs). The European Commission recommended mandatory testing for OSAS, before a driver's license is granted or renewed.
This collection provides the newest research, comprehensive background information and up-to-date information on obstructive sleep apnea syndrome.
Call for papers: If you wish to submit your manuscript on obstructive sleep apnea syndrome (OSAS), please follow the instructions and submit your manuscript in Editorial Manager. Please select the thematic series upon submission.
Featured review: Recent advances in capsule-based dry powder inhaler technology
Pulmonary drug delivery is currently the focus of accelerated research and development because of the potential to produce maximum therapeutic benefit to patients by directly targeting drug to the site of pathology in the lungs. Among the available delivery options, the dry powder inhaler (DPI) is the preferred device for the treatment of an increasingly diverse range of diseases. This article reviews recent advances in capsule-based DPI technology and the introduction of the ‘disposable’ DPI device.
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Featured article: Longitudinal assessment of bleomycin-induced lung fibrosis by Micro-CT correlates with histological evaluation in mice
The intratracheal instillation of bleomycin in mice induces early damage to alveolar epithelial cells and development of inflammation followed by fibrotic tissue changes. Histopathology is the gold standard for assessing lung fibrosis in rodents, however it precludes repeated and longitudinal measurements of disease progression. This study investigates the use of the Micro-CT technique to allow the evaluation of disease onset and progression at different time-points in the mouse bleomycin model of lung fibrosis.
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