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  1. Research Article

    Antibiotic therapy, supportive treatment and management of immunomodulation-inflammation response in community acquired pneumonia: review of recommendations

    Community-acquired pneumonia is a common and serious disease, with high rates of morbidity and mortality. Management and treatment of community-acquired pneumonia are described in three main documents: the 200...

    Marco Mantero, Paolo Tarsia, Andrea Gramegna, Sonia Henchi, Nicolò Vanoni and Marta Di Pasquale

    Multidisciplinary Respiratory Medicine 2017 12:26

    Published on: 5 October 2017

  2. Case Report

    Second lung malignancy and Richter syndrome in chronic lymphocytic leukemia: case report and literature review

    Chronic lymphocytic leukemia (CLL) is the most frequent lymphoproliferative disease. Transformation into Richter disease and occurrence of second malignancies involving the lungs are rare complications. The ha...

    Ghassen Soussi, Selsabil Daboussi, Samira Mhamdi, Zied Moatemri, Hela Ghedira, Chiraz Aichaouia, Mohsen Khadhraoui, Faouzi El Mezni and Rezaik Cheikh

    Multidisciplinary Respiratory Medicine 2017 12:24

    Published on: 29 September 2017

  3. Original research article

    Effects of combination therapy indacaterol/glycopyrronium versus tiotropium on moderate to severe COPD: evaluation of impulse oscillometry and exacerbation rate

    Small airways are considered the major site of airflow limitation in COPD. Impulse oscillometry (IOS) is a forced oscillation technique, which provides passive measurement of lung mechanics. It can differentia...

    Antonio Molino, Francesca Simioli, Anna Agnese Stanziola, Mauro Mormile, Maria Martino and Maria D’Amato

    Multidisciplinary Respiratory Medicine 2017 12:25

    Published on: 27 September 2017

  4. Review

    Desmoplastic small round cell tumors of the pleura: a review of the clinical literature

    Desmoplastic small round cell tumor of the pleura is a rare malignancy, with only a few cases reported in the scientific literature. The aim of the present review is to discuss the demographic, pathological, c...

    Alessandro Giuseppe Fois, Pietro Pirina, Antonella Arcadu, Francesca Becciu, Sandra Manca, Viviana Marras, Sara Canu, Gaetano Castagna, Giorgio Carlo Ginesu, Angelo Zinellu and Panagiotis Paliogiannis

    Multidisciplinary Respiratory Medicine 2017 12:22

    Published on: 9 September 2017

  5. Original research article

    Could Eosinophilia predict clinical severity in nasal polyps?

    Although nasal polyps are one of the most frequent diseases, their etiopathogenesis remains unclear.Since eosinophils are the main inflammatory cells in the substantial proportion of nasal polyp tissues, they ...

    Figen Aslan, Eren Altun, Serpil Paksoy and Gulay Turan

    Multidisciplinary Respiratory Medicine 2017 12:21

    Published on: 21 August 2017

  6. Original research article

    Implementation of GOLD consensus report in real life: results from the Velletri-Lariano (VELA) cohort

    COPD is one of the leading causes of morbidity and mortality. Pharmacotherapy improves quality of life and reduces exacerbations although low adherence with prescribed treatments may represent a barrier to opt...

    G. De Filippi, M. Lallini, G. De Riggi, G. Marchetti, C. M. Dimartino, A. M. Russetti, E. Ferrari, R. Pistelli, M. S. Magnoni, M. Riparbelli, A. Rizzi and P. Angeletti

    Multidisciplinary Respiratory Medicine 2017 12:18

    Published on: 17 July 2017

  7. Original research article

    Mutational status predicts the risk of thromboembolic events in lung adenocarcinoma

    Precision medicine promises to improve prognosis of patients affected by untreatable diseases. Patients with lung cancer (especially lung adenocarcinoma) bear an increased risk of VTE. Mutations in the EGFR an...

    Elsa Davidsson, Nicola Murgia, Cristian Ortiz-Villalón, Emil Wiklundh, Magnus Sköld, Karl Gustav Kölbeck and Giovanni Ferrara

    Multidisciplinary Respiratory Medicine 2017 12:16

    Published on: 3 July 2017

  8. Original research article

    Instant velocity and consistency of emitted cloud change by the different levels of canister filling with Metered Dose Inhalers (MDIs), but not with Soft Mist Inhalers (SMIs): a bench study

    Inhalation is the preferred route for respiratory drug delivery, but several factors contribute to the variability of the respirable dose fraction. Instant velocity and the dynamic characteristics of the dropl...

    Roberto W. Dal Negro, Pietro Longo, Orestepaolo Villanis Ziani, Luca Bonadiman and Paola Turco

    Multidisciplinary Respiratory Medicine 2017 12:13

    Published on: 5 June 2017

  9. Review

    Recent advances in capsule-based dry powder inhaler technology

    Pulmonary drug delivery is currently the focus of accelerated research and development because of the potential to produce maximum therapeutic benefit to patients by directly targeting drug to the site of path...

    Federico Lavorini, Massimo Pistolesi and Omar S. Usmani

    Multidisciplinary Respiratory Medicine 2017 12:11

    Published on: 22 May 2017

    The Erratum to this article has been published in Multidisciplinary Respiratory Medicine 2017 12:19

  10. Original research article

    Using PaCO2 values to grade obesity-hypoventilation syndrome severity: a retrospective study

    To date, an important aspect that has still not been clarified is the assessment of OHS severity. The purpose of this retrospective study was to evaluate whether grading OHS severity according to PaCO2 values may...

    Mario Francesco Damiani, Vito Antonio Falcone, Pierluigi Carratù, Cristina Scoditti, Elioda Bega, Silvano Dragonieri, Alfredo Scoditti and Onofrio Resta

    Multidisciplinary Respiratory Medicine 2017 12:14

    Published on: 18 May 2017

  11. Review

    The evidence on tiotropium bromide in asthma: from the rationale to the bedside

    Severe and poorly controlled asthma still accounts for a great portion of the patients affected. Disease control and future risk management have been identified by international guidelines as the main goals in...

    Dejan Radovanovic, Pierachille Santus, Francesco Blasi and Marco Mantero

    Multidisciplinary Respiratory Medicine 2017 12:12

    Published on: 4 May 2017

    The Erratum to this article has been published in Multidisciplinary Respiratory Medicine 2017 12:17

  12. Review

    Tele-medicine in respiratory diseases

    Information and Communication Technologies applied to health care and advances in sensor and data transmission technology allowed tele-medicine based programs of care also for patients with respiratory diseases.

    Nicolino Ambrosino, Dewi Nurul Makhabah and Yusup Subagio Sutanto

    Multidisciplinary Respiratory Medicine 2017 12:9

    Published on: 20 April 2017

  13. Original research article

    Longitudinal assessment of bleomycin-induced lung fibrosis by Micro-CT correlates with histological evaluation in mice

    The intratracheal instillation of bleomycin in mice induces early damage to alveolar epithelial cells and development of inflammation followed by fibrotic tissue changes and represents the most widely used mod...

    Francesca Ruscitti, Francesca Ravanetti, Jeroen Essers, Yanto Ridwan, Sasha Belenkov, Wim Vos, Francisca Ferreira, Alex KleinJan, Paula van Heijningen, Cedric Van Holsbeke, Antonio Cacchioli, Gino Villetti and Franco Fabio Stellari

    Multidisciplinary Respiratory Medicine 2017 12:8

    Published on: 10 April 2017

  14. Review

    A reappraisal of the mucoactive activity and clinical efficacy of bromhexine

    Since its introduction to the market in 1963, bromhexine, an over-the-counter drug, has been investigated for its activity in animal models and in humans with diverse respiratory conditions. Bromhexine is a de...

    Alessandro Zanasi, Massimiliano Mazzolini and Ahmad Kantar

    Multidisciplinary Respiratory Medicine 2017 12:7

    Published on: 20 March 2017

  15. Original research article

    Characteristics of an optimized patient information material for elderly patients with obstructive pulmonary diseases based on patients’ and experts’ assessment

    Life-long regular use of drugs is necessary in chronic diseases like asthma and COPD. There are several methods to improve adherence including patient information and education; however, their effectiveness on...

    Gábor Tomisa, Alpár Horváth, Brigitta Dombai and Lilla Tamási

    Multidisciplinary Respiratory Medicine 2017 12:6

    Published on: 14 March 2017

  16. Letter to the Editor

    Ventilator associated pneumonia or ventilator induced pneumonia

    Ventilator associated pneumonia currently in vogue seems to have some pitfalls as far as the nomenclature is concerned and thus it imparts an erroneous impression to the reader. As the driving force is in fact...

    Zahid Hussain Khan, Piero Ceriana and Claudio F. Donner

    Multidisciplinary Respiratory Medicine 2017 12:5

    Published on: 28 February 2017

  17. Letter to the Editor

    Once daily aerosolised tobramycin in adult patients with cystic fibrosis in the management of Pseudomonas aeruginosa chronic infection

    It is estimated that about 60–70% of Cystic Fibrosis patients develop Pseudomonas aeruginosa chronic infection, with progressive loss of lung function, as well as increased antibiotic resistance and mortality.

    Marco Mantero, Andrea Gramegna, Giovanna Pizzamiglio, Alice D’Adda, Paolo Tarsia and Francesco Blasi

    Multidisciplinary Respiratory Medicine 2017 12:2

    Published on: 7 February 2017

  18. Original research article

    Pulmonary arterial hypertension associated with interferon therapy: a population-based study

    Isolated cases of pulmonary arterial hypertension (PAH) with interferon α or β therapy have been reported, but no population-based estimates of the incidence of the disease after interferon exposure are availa...

    Ravikanth Papani, Alexander G. Duarte, Yu-li Lin, Yong-Fang Kuo and Gulshan Sharma

    Multidisciplinary Respiratory Medicine 2017 12:1

    Published on: 17 January 2017

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