Table 1 Characteristics at baseline of 4,217 patients who underwent a methacholine challenge test
From: BMI can influence adult males’ and females’ airway hyperresponsiveness differently
Underweight | Normal weight | Overweight | Obese | Total | p | |
|---|---|---|---|---|---|---|
N. patients (M/F) | 87 (20/67)* | 2255 (1087/1168)*° | 1300 (757/543)*° # | 575 (205/370)*° # | 4217 (2069/2148) | 0.0001 |
Age | 29±11* | 34±13*° | 42±15*° # | 47±15*° # | 38±15 | 0.0001 |
1 Current mokers (%) | 24 (31.2%) | 490 (24.9%) | 205 (17.6%) | 72 (14.3%) | 791 (21.3%) | |
1 Ex smokers (%) | 1 (1.3%) | 101 (5.1%) | 127 (10.9%) | 65 (12.9%) | 294 (7.9%) | 0.0001 |
1 Non-Smokers | 52 (67.5%) | 1376 (70.0%) | 831 (71.5%) | 367 (72.8%) | 2626 (70.8%) | |
Patients with normal reactivity | 34 (39.1%) | 903 (40.0%) | 530 (40.8%) | 230 (40.0%) | 1697 (40.2%) | 0.969 |
Patients with PD 20 <3200 μg | 53 (60.9%) | 1352 (60.0%) | 770 (59.2%) | 345 (60.0%) | 2520 (59.8%) | |
FEV 1 % of predicted | 96.96 [87.43-103.43]*° # | 100 [92.34-107.83]* | 100 [91.79- 108.60]° | 100 [90.26- 107.87]# | 100 [91.88-107.97] | 0.007 |
FVC % of predicted | 92.06 [86.74-98.54]*° # | 98.84 [91.15-107.33]* | 100.0 [92.16-108.36]° | 99.77 [90.49-107.85]# | 99.11 [91.21-107.60] | 0.0001 |
FEV 1 /FVC | 90.04 [84.94-95.03]*° # | 86.79 [81.80-91.56]* | 84.69 [80.09-88.53]° | 84.10 [80.76-88.20]# | 85.77 [81.10-90.05] | 0.0001 |
BMI | 17.61±1.75* | 22.17±1.71*° | 27.10±1.39*° # | 33.53±3.90*° # | 25.14±4.58 | 0.0001 |