Diagnostic utility of serum and pleural levels of adenosine deaminase 1–2, and interferon-γ in the diagnosis of pleural tuberculosis

Table 3 Pleural and serum adenosine deaminase and interferon-γ levels evaluated for the diagnostic accuracy of pleural tuberculosis

	Cut-off (U/L)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	AUC ± Sh	p Value
Pleural ADA-1	>16.8	69.77	68	65.2	72.3	0.750 ± 0.051	0.0001
Pleural ADA-2	>20.37	95.35	86	85.4	95.6	0.936 ± 0.027	0.0001
Pleural total ADA	>40.68	88.37	88	86.4	89.8	0.925 ± 0.029	0.0001
Pleural IFN-γ	>110	74.42	68	66.7	75.6	0.759 ± 0.051	0.0001
Serum ADA-1	≤5.34	34.78	89.66	72.7	63.4	0.515 ± 0.081	0.8536
Serum ADA-2	>13.64	69.57	75.86	69.6	75.9	0.759 ± 0.069	0.0002
Serum total ADA	>23.07	86.96	55.17	60.6	84.2	0.694 ± 0.074	0.0095
Serum IFN-γ	>70	56.52	68.97	59.1	66.7	0.567 ± 0.081	0.4096

ADA, Adenosine deaminase; AUC, Area under the curve; IFN-γ, Interferon gamma; NPV, Negative predictive value; PPV, Positive predictive value.

ISSN: 2049-6958