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Table 3 Pleural and serum adenosine deaminase and interferon-γ levels evaluated for the diagnostic accuracy of pleural tuberculosis

From: Diagnostic utility of serum and pleural levels of adenosine deaminase 1–2, and interferon-γ in the diagnosis of pleural tuberculosis

  Cut-off (U/L) Sensitivity (%) Specificity (%) PPV (%) NPV (%) AUC ± Sh p Value
Pleural ADA-1 >16.8 69.77 68 65.2 72.3 0.750 ± 0.051 0.0001
Pleural ADA-2 >20.37 95.35 86 85.4 95.6 0.936 ± 0.027 0.0001
Pleural total ADA >40.68 88.37 88 86.4 89.8 0.925 ± 0.029 0.0001
Pleural IFN-γ >110 74.42 68 66.7 75.6 0.759 ± 0.051 0.0001
Serum ADA-1 ≤5.34 34.78 89.66 72.7 63.4 0.515 ± 0.081 0.8536
Serum ADA-2 >13.64 69.57 75.86 69.6 75.9 0.759 ± 0.069 0.0002
Serum total ADA >23.07 86.96 55.17 60.6 84.2 0.694 ± 0.074 0.0095
Serum IFN-γ >70 56.52 68.97 59.1 66.7 0.567 ± 0.081 0.4096
  1. ADA, Adenosine deaminase; AUC, Area under the curve; IFN-γ, Interferon gamma; NPV, Negative predictive value; PPV, Positive predictive value.