Table 2 Characteristics of clinical studies comparing levodropropizine to controls in adults
From: Levodropropizine for treating cough in adult and children: a meta-analysis of published studies
Study | Design | Participants | Intervention vs. comparator | Condition | Outcomes |
|---|---|---|---|---|---|
Allegra 1988 | RCT ,double-blind Oral administration t.i.d. for 3 days | Adults N = 40 Age: >13 yrs | Levodropropizine vs. placebo | Bronchitis cough | Higher reduction in cough severity with levodropropizine |
Catena 1997 | RCT , double-blind, double-dummy, two parallel groups Oral administration t.i.d. for 5 days | Adults N = 209 Age: 18–75 yrs | Levodropropizine vs. dextromethorphan | Moderate non-productive cough | Significant reduction in cough frequency with both treatments; Levodropropizine significantly more effective in reducing nocturnal awakenings |
Luporini 1998 | RCT, double-blind, two parallel gropus Oral administration t.i.d. for 7 days | Adults N = 140 > 18 yrs | Levodropropizine vs. dihydrocodeine | Lung cancer cough | Significant reduction in cough severity and nocturnal awakenings with both treatments |