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Table 2 Factors associated with the likelihood of developing pulmonary hypertension

From: Pulmonary arterial hypertension associated with interferon therapy: a population-based study

Patient characteristics

Hazard ratio (95% CI)

Indication for interferon

 Multiple sclerosis

Reference

 Hepatitis C

1.43 (0.69, 2.96)

Age

 20–29

Reference

 30–39

0.26 (0.02, 4.23)

 40–49

1.46 (0.19, 11.19)

 50–59

2.41 (0.32, 18.29)

 60–65

4.05 (0.49, 33.36)

Gender

 Male

Reference

 Female

1.02 (0.62, 1.68)

Comorbidity, Yes vs No

 Hypertension

1.43 (0.84, 2.43)

 Other liver diseasea

3.21 (1.93, 5.34)

 Diabetes

2.27 (1.25, 4.11)

 Chronic pulmonary disease

1.92 (0.82, 4.50)

 Sleep apnea

1.31 (0.31, 5.56)

 Connective tissue disorder

4.32 (1.71, 10.96)

 Obesity

0.73 (0.10, 5.51)

 HIV/AIDS

2.63 (0.63, 10.89)

 Valvular disease

3.76 (1.16, 12.21)

 Congestive heart failure

1.10 (0.15, 8.17)

  1. Note: Congenital heart disease and atrial fibrillation and flutter were not included in the model because there were no events among patients with such comorbidities. This model was adjusted for the year of the initial interferon treatment. aDoes not include hepatitis C