Table 1 Summary of preclinical studies on bromhexine

Merker 1966 [8]

Rats, bronchial secretory cells

4-20 mg/kg/24 h parenteral

Quantitative and qualitative effect on mucus production

Janatuinen 1969 [10]

Guinea pigs, bronchial goblet cells

5-10 mg/kg/24 h parenteral

Reduction in goblet cells, increased secretory material in airways

Gil 1971 [11]

Rats, type II alveolar cells

200 mg/kg/24 h enteral

Increased secretion of phospholipids in alveolar space

Harada 1977 [12]

Dogs, tracheal mucosa

4 mg intravenous

Increase in the output of secretion; goblet cells and submucosal mucus glands emptying

Von Wichert 1977 [14]

Rabbits, lung and liver tissues

10 mg/kg intravenous

Rapid stimulation of phospholipid synthesis

Martin 1993 [27]

Pigs, rheological characteristics of tracheal mucus

0,5 mg/kg

Increased concentration of oxytetracycline within the secreted mucus and reversed mucospastic activity of oxytetracycline in vivo