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Table 1 PHASE 3 Judging risk of bias

From: The history and epidemiology of Middle East respiratory syndrome corona virus

Domain

Concern

Rationale for concern

Concerns regarding specification of the study eligibility criteria

Non –confirmed cases

Decrease the risk of bias (false positive)

Concerns regarding methods used to identify and/or select studies.

None

None

Concerns regarding used to collect data and appraise the studies

Repeated article

Increase the false positive results

Concerns regarding the synthesis and findings

Different finding between the article

To direct the results toward the major finding and analyzed it

Describe whether conclusions were supported by the evidence:

 A. Did the interpretation of findings address all of the concerns identified in Domain 1 to 4?

Yes

 B. Was the relevance of identified studies to the review’s research question appropriately considered?

Probably yes

 C. Did the reviewers avoid emphasizing results on the basis of their statistical significance?

Yes

Risk of bias in the review

Risk: Low