Criteria for enhancing mucus transport: a systematic scoping review

Pieterse, Alison; Hanekom, Susan D.

doi:10.1186/s40248-018-0127-6

Multidisciplinary Respiratory Medicine

Table 1 Papers included in the review

From: Criteria for enhancing mucus transport: a systematic scoping review

Author	Year	Phase			Physiological factor or intervention
Author	Year	Preclinical	Phase 0	PC + 0	Physiological factor or intervention
Agarwal M, King M and Shukla JB	1994	×			Epithelial differences
Bennett WD; Foster WM; Chapman WF	1990		×		Forced expiratory technique and cough
Button B; Picher M; Boucher RC	2007	×			ATP
Diesel DA; Lebel JL; Tucker A	1991	×			Temperature and humidity
Eckerbom B; Lindholm CE; Mannting F	1991	×			Temperature and humidity
Freitag L; Kim CS; Long WM; Venegas J; Wanner A	1989	×			Generation of oscillation
Freitag, L., Long, W.M., Kim, C.S.	1989	×			Generation of oscillation
Gatto LA; Houck BM	1989	×			Epithelial differences
Gross, D., Zidulka, A., O’Brien, C., Wight, R., Fraser, R., Rosenthal, L., King, M.	1985	×			Generation of oscillation
Kilgour E; Rankin N; Ryan S; Pack R	2004	×			Temperature and humidity
Kim, C.S., Greene, M.A., Sankaran, S.	1986	×			Ventilation patterns/Air flow
Kim, C.S., Iglesias, A.J.	1987	×			Ventilation patterns/Air flow
King M	1987	×			Mucus properties
King M, Phillips DM, Gross D, Vartian V, Change HK and Zidulka A	1983	×			Generation of oscillation
King, M., Phillips, D.M., Zidulka, A., Chang, H.K.	1984	×			Generation of oscillation
King M, Zahm JM, Pierrot D, Vaquez-Girod S and Puchelle E	1989	×			Mucus properties
King M; Zidulka A; Phillips DM; Wight D; Gross D; Chang HK	1990	×			Generation of oscillation
Li Bassi G; Saucedo L; Marti JD; Rigol M; Esperatti M; Luque N; Ferrer M; Gabarrus A; Fernandez L; Kolobow T	2012	×			Ventilation patterns/Air flow
Li Bassi G; Zanella A; Cressoni M; Stylianou M; Kolobow T	2007	×			Positioning
Lippmann M, Albert RE, Yeates DB, Berger JM, Foster WM, Bohning DE	1975	×			Temperature and humidity
Martí, Joan Daniel; Li Bassi, Gianluigi; Rigol, Montserrat; Saucedo, Lina; Ranzani, Otavio Tavares; Esperatti, Mariano; Luque, Nestor; Ferrer, Miquel; Vilaro, Jordi; Kolobow, Theodor; et al.	2013	×			Generation of oscillation
Mortensen J; Jensen C; Groth S; Lange P	1991		×		Forced expiratory technique and cough
Piccin VS; Calciolari C; Yoshizaki K; Gomes S; Albertini-Yagi C; Dolhnikoff M; Macchione M; Caldini EG; Saldiva PH; Negri EM	2011	×			Ventilation patterns/Air flow
Puchelle E; Zahm JM; Jacquot J; Pierrot D	1989	×			Temperature and humidity
Radford, R., Barutt, J., Billingsley, J.G.	1982			×	Generation of oscillation
Ragavan AJ; Evrensel CA; Krumpe P	2010	×			Generation of oscillation
Rubin EM; Scantlen GE; Chapman GA; Eldridge M; Menendez R; Wanner A	1989	×			Generation of oscillation
Sears PR, Yin W-N, Ostrowski LE	2015	×			Temperature and humidity
Tatkov, S., Pack, R.J.	2011	×			Generation of oscillation
Trawöger R; Kolobow T; Patroniti N; Forcier K	2002	×			Ventilation patterns/Air flow
Volpe MS; Adams AB; Amato MBP; Marini JJ	2008	×			Ventilation patterns/Air flow
Wagner, E.M, Foster, W.M.	1996	×			Bronchial perfusion
Wong, J.W., Keens, T.G., Wannamaker, E.M., (...), Levison, H., Aspin, N.	1977		×		Positioning
Yang TQ; Majima Y; Guo Y; Harada T; Shimizu T; Takeuchi K	2002	×			Epithelial differences
Zahm JM; Pierrot D; Vaquez-Girod S; Duvivier C; King M; Puchelle E	1989	×			Mucus properties

Preclinical study:
Research using animals to find out if a drug, procedure, or treatment is likely to be useful. Preclinical studies take place before any testing in humans is done (https://www.cancer.gov/publications/dictionaries/cancer-terms?cdrid=44517 accessed 18/09/17)
A study to test a drug, a procedure, or another medical treatment in animals. The aim of a preclinical study is to collect data in support of the safety of the new treatment. Preclinical studies are required before clinical trials in humans can be started (http://www.medicinenet.com/script/main/art.asp?articlekey=5019 accessed 18/09/17)
Laboratory test of a new drug or a new invasive medical device on animal subjects; conducted to gather evidence justifying a clinical trial (http://www.thefreedictionary.com/preclinical+trial accessed 18/09/17)
Phase 0 clinical trial:
Even though phase 0 studies are done in humans, this type of study isn’t like the other phases of clinical trials. The purpose of this phase is to help speed up and streamline the drug approval process. Phase 0 studies are exploratory studies that often use only a few small doses of a new drug in a few patients. Phase 0 studies help researchers find out whether the drugs do what they’re expected to do. This process may help avoid the delay and expense of finding out years later in phase II or even phase III clinical trials that the drug doesn’t act as expected to based on lab studies (https://www.cancer.org/treatment/treatments-and-side-effects/clinical-trials/what-you-need-to-know/phases-of-clinical-trials.html - accessed 20/09/17)

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