DISEASE | ILD | OLD | PAH |
---|---|---|---|
RA | Older age; male sex, smoking history; ACPA positivity, LDH, longstanding or persistently active disease; rheumatoid nodules, articular erosions, genetic predisposition (HLA linked) | Smoking, older age | |
SSDs | Scl70, Th/To positivity, dSSc, smoking, older age, rapidly progressive disease. | ACA, LAC, and anti RNA polymerase I, II, III, AECA positivity, older age, RP, NVC positivity; telangiectasias, seric NT-pro-BNP and urate, RAD, RAA, TV, PE | |
IIMs | Cutaneous manifestations; telangiectasias, RP, ATSA positivity (rapidly progressive for non-Jo1 positivity); older age, acute/subacute onset, CADM, Hamann Rich presentation correlated with worse prognosis | Cutaneous manifestations, peripheral microangiopathy, positivity for SSA/Ro, severe ILD, polyarthralgia, longstanding disease | |
SjS | Hypergammaglobulinemia, lymphopenia, RF, SSA/Ro, SSB/La positivity | Sicca syndrome, smoking | RP, PE, hepatic injury, RF positivity |
SLE | APLA, cardiac or vascular dysfunction, ILD, SLS |