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Table 2 Patient-reported outcomes

From: Observational vignette study to examine patient and healthcare provider perceived impact of asthma-related exacerbations in the US

Patient-reported outcomes Patients (N = 302)
EQ-5D-5 L domains
Proportion of patients reporting problems/impact, n (%)
 Pain/discomfort 162 (53.6)
 Anxiety/depression 142 (47.0)
 Usual activities 115 (38.1)
 Mobility, ability to walk about 108 (35.8)
 Self-care (i.e. washing or dressing) 28 (9.3)
EQ-5D VAS, mean (SD)a 74.2 (16.0)
Sleep impact (proportion reporting impact), n (%) 149 (49.3)
ACT
Total ACT scoreb, mean (SD) 20.3 (4.3)
ACT levels of asthma control, n (%)
 Poorly controlled (score < 16) 48 (15.9)
 Somewhat controlled (score 16–19) 62 (20.5)
 Well controlled (score > 19) 192 (63.6)
WPAI
Currently employed, n (%) 171 (56.6)
WPAI summary scoresc, mean (SD)
 Proportion of respondents missing at least 1 h from work during the past 7 days due to asthmad, n (%) 16 (9.4)
 Percent work time missed due to asthma during the past 7 days (absenteeism)e 3.1 (12.7)
 Percent impairment while working due to asthma during the past 7 days (presenteeism)f 11.8 (20.4)
 Percent overall work impairment (absenteeism and presenteeism during the past 7 days)g 13.1 (22.4)
 Percent impairment, regular daily activities during the past 7 days h 19.3 (24.7)
Patient exacerbationsi, yes, n (%)
 Proportion of respondents who ever experienced an exacerbation, flare-up, or attack 230 (76.2)
 A mild exacerbation, flare-up, or attack in the past 12 months 174 (57.6)
 Amoderate exacerbation, flare-up, or attack in the past 12 months 89 (29.5)
 A severe exacerbation, flare-up, or attack in the past 12 months 39 (12.9)
Patient belief statements, yes, n (%)
 I believe it is helpful to categorize asthma attacks or flare-ups by severity (mild, moderate, severe) 292 (96.7)
 I believe all patients with asthma are at risk of developing an attack or flare-up 274 (90.7)
 I believe asthma attacks or flare-ups can have a varying impact on my life, depending on the severity of the exacerbation 275 (91.1)
 I believe asthma attacks or flare-ups have an impact on my life 236 (78.1)
 I believe my asthma attacks or flare-ups have an impact on other people in my life 212 (70.2)
 I worry about having asthma attacks or flare-ups. 150 (49.7)
  1. aRanges from 0 (worst health imaginable) to 100 (best health imaginable). bRanges from 5 to 25; higher values indicate better asthma control. cCalculated from patients who indicated they were currently employed, with the exception of “Percent Impairment in Regular Daily Activities in the Past 7 Days”, which was calculated for all respondents. dN = 171. eNumber of hours missed because of asthma divided by the sum of that number plus the number of hours actually worked. If either value was missing or if both were zero, percent absenteeism was set to missing; N = 151. fPresenteeism is only reported for those respondents who entered > 0 h actually worked in the past 7 days; N = 150. gN = 150. hN = 302. iExacerbation definitions by severity are provided in Additional file 2
  2. ACT Asthma Control Test, EQ-5D-5 L 5-level quality of life survey instrument developed by EuroQol Group, EQ-VAS EQ Visual Analogue Scale, SD standard deviation, WPAI Work Productivity and Activity Impairment