- Original research article
- Open Access
Patient reported experiences of CT guided lung biopsy: a prospective cohort study
© Winn et al.; licensee BioMed Central Ltd. 2014
- Received: 25 August 2014
- Accepted: 29 September 2014
- Published: 31 October 2014
CT guided lung biopsy is a commonly performed procedure to obtain tissue for a histological diagnosis in cases of suspected lung cancer.
This is a prospective cohort study to obtain information directly from patients about their experiences of the biopsy procedure, thus obtaining a more accurate picture of complications compared with previously performed retrospective reviews. Patients participated in a post-procedure telephone interview and information was gathered about any procedural complications and personal experiences. We also compared the patient reported complications with those obtained from a retrospective review of hospital databases, analogous to previously performed retrospective studies.
In our patient group, reported procedural complication rates were 10% pneumothorax rate (4% requiring a chest drain) and 10% haemoptysis. Post-procedural pain and shortness of breath showed positive correlation, with one patient experiencing prolonged pain. No statistical difference was found between the patient reported complication rates and those obtained from retrospective review of the hospital database.
Our study demonstrates CT guided lung biopsy is a safe procedure and is generally well tolerated. Some patients may experience significant and lasting pain and therefore should be counselled about this pre-procedure.
- CT guided biopsy
- Lung carcinoma
CT guided lung biopsy is a common radiological procedure performed throughout the world. It is frequently used to obtain tissue to confirm a suspected diagnosis of lung cancer to enable the histological analysis necessary for treatment planning. The procedure may also be performed for non-malignant disease, such as to obtain a specimen for microbial analysis in suspected infection. However, the majority of biopsies are for malignant disease.
Within the County Durham and Darlington Foundation Trust approximately 120 CT guided lung biopsies are performed per year across the three hospital sites. Complications of CT guided lung biopsy have been well documented and include pneumothorax (4-60%), pneumothorax requiring chest drain (5-10%), haemoptysis (10%), pain, air embolism, atrial fibrillation, tumour seeding of the biopsy tract and, on rare occasions, death (0.5%)[1–13]. To our knowledge and after an extensive literature search, all studies and procedure audits performed to date have been retrospective analyses of hospital databases, PACS (Picture Archiving and Communication System) image databases and patient notes. There have been no prospective studies directly questioning patients regarding their experiences. We propose that the reported complication rates are under-representative and only include those patients who presented to the specific hospital in the study. Patients who represented post lung biopsy to a different hospital, who consulted or sought advice from primary care services or who had symptoms after the biopsy but did not seek medical treatment would be missed from the current literature. Any less severe complications (such as minor haemoptysis) not requiring physician input would also be missed. We believe that by consulting the patients directly a more accurate assessment of the true complication rates of CT guided lung biopsy will be possible.
What is the patient reported complication rate following CT guided lung-biopsy?
Are patients adequately informed regarding the procedure and aftercare?
This was a prospective cross sectional survey of 49 patients (40% recruitment rate) who underwent CT guided lung biopsy within County Durham and Darlington Foundation Trust. Ethical approval was granted by the County Durham and Tees Valley Ethics Committee and funding was provided by County Durham and Darlington Foundation Trust.
Adult patients with capacity were eligible for inclusion in the study if they had previously undergone a CT examination of the chest demonstrating an abnormality within the chest that was suspected to be malignant or indeterminate. Patients were excluded from the study if they were under 18 years of age, lacked capacity or were not contactable by telephone. Patients were invited to participate in the study during a clinic appointment with the referring physician and an information leaflet was supplied. Further information about the study was given by the research nurse prior to the procedure and written and informed consent was taken to participate in the study. The patients were re-assured that they could withdraw their consent at any time without detriment to their future care. Consent for the procedure was taken by the physician performing the biopsy, separately from the consent for involvement in the study.
The CT guided biopsy was performed to a standard technique by one of two Consultant Radiologists (JS, PO): the patient was placed within the CT scanner and a suitable position for biopsy was ascertained. Local anaesthetic was infiltrated into the sub-cutaneous tissues and an 18G core biopsy needle was placed within the lesion. Usually, one to three samples were taken, depending on radiologist preference and the subjective opinion of whether an adequate sample had been obtained. No pathology service was available to analyse the sample at the time of the biopsy to check for adequacy. Routine post-procedure care included observation within the hospital for four hours. Additionally, a post-procedure chest radiograph was obtained to determine whether the patient had sustained a pneumothorax. Patients who were well post biopsy were discharged home after four hours. If the patient was unwell, then local hospital admission was arranged.
Within two weeks following the procedure, the patients were telephoned by the study nurse and a structured telephone interview was undertaken. It was made clear to the patients at the time of the biopsy that the purpose of the telephone interview was to discuss the biopsy procedure and not the biopsy results. The patients were informed that the biopsy results would be obtained from the referring physician during their next clinic appointment and that the study nurse did not have any information about the biopsy results.
Questions asked during telephone interview
Pain (duration and score out of ten)
Was the biopsy what they expected?
Immediate shortness of breath (score out of ten)
What information were they given before the biopsy and by whom?
Haemoptysis – estimate of volume (for example tea spoon-full, egg cup-full)
Did they feel that more information is needed before arriving at the hospital for the biopsy?
Additional procedures following biopsy (for example chest drain insertion)?
How could the service be improved?
Length of stay post procedure?
Did they need to consult primary care services – GP/NHS direct?
Were they admitted to any other hospital since the procedure?
On average, the interview lasted 20 minutes. All patients who agreed to participate in the study were contacted post-biopsy and no patients withdrew their consent. The qualitative information was initially recorded on paper and then collated into a database.
Statistical tests were performed using StatsDirect (http://www.statsdirect.com). The number of patients recruited into our study gives 80% power to detect a 20% difference between the two groups. The Fisher exact test was used to compare the patient reported rates of haemoptysis and pneumothorax against the rates from retrospective review of the hospital records, with no difference between the two groups evident in the results.
Spearman rank correlation test shows a strong positive correlation between the immediate pain scores and shortness of breath scores (p = 0.0022). Positive correlation is also demonstrated between the immediate and one week pain scores (p = 0.0607).
In total, 49 patients were recruited to the study over 15 months. There were 28 male and 21 female patients, with ages ranging from 34 to 87.
Patient reported results
Forty six (94%) patients were discharged on the same day of the biopsy following uneventful 4 hour post-procedure observation. One patient required an overnight stay, one patient stayed for two days and one patient required hospitalisation for more than two days. The patients were all admitted to Darlington Memorial Hospital, within County Durham and Darlington Foundation Trust.
There were no additional complications occurring between hospital discharge and the post-procedure interview at two weeks.
All forty six patients (94%) answered “yes” to the question “was the biopsy what they were expecting?” whereas 3 patients answered “no”. No patients felt that they required more information and none volunteered any additional comments.
Retrospective review of hospital records
Review of the hospital records showed that 5 out of 49 (10%) patients sustained a pneumothorax. Two patients required a chest drain, in concordance with the patient reported rate. Out of this group, one patient sustained a large pneumothorax, requiring a chest drain and hospitalisation for greater than two days. A further patient had a 40% pneumothorax requiring a chest drain and an overnight stay in hospital. The three other patients sustained small apical pneumothoraces, none requiring a chest drain. One of these patients with a small apical pneumothorax required a two day in-patient admission.
Five patients were recorded as having post-procedural haemoptysis (10%) and 44 as none. No patients required any active treatment of the haemoptysis (such as embolisation) and all settled with conservative management.
20% of our patients answered “yes” to the question “was the procedure painful?” Therefore, 80%, or the majority, tolerated it without discomfort. Similarly, 29% of our patients were short of breath during or immediately after the procedure and, therefore, 71% tolerated it without significant dyspnoea. Our results show positive correlation between immediate pain and shortness of breath, indicating that those patients who were in painwere also short of breath. This result may be expected intuitively. If the procedures were poorly tolerated, a patient may experience more pain and dyspnoea.
Of interest, in our opinion, although only 10 patients answered “yes” to the direct question about procedural pain, 25 patients scored their immediate level of pain as greater than 0 (i.e. some pain) with the majority scoring 1-2/10 for pain. This suggests that there was a group of people who experienced discomfort/low pain scores immediately following the procedure but chose not to describe the procedure overall as painful. Therefore, just under half of the patients found the procedure painful to some extent, but chose not to admit it on direct questioning. A methodological strength of our study is that it was prospective and the researchers were not part of the team providing immediate clinical care. This may have led to more honesty from the patients about the complications, particularly the peri and post procedural pain.
A positive correlation is also shown between immediate pain scores and scores at one week. This could be explained on the basis of an individual’s pain threshold. Those patients who scored their pain level as > 5 immediately, also gave relatively high scores at one week. All but one patient scored their pain level as less at one week, compared with the immediate post procedure pain scores. It is relevant that the single patient who scored his pain greater at one week compared with immediately post procedure sustained a small pneumothorax, managed conservatively.
Pain is subjective and a small number of patients found the procedure painful and experienced sustained pain for up to one week following the procedure.
Three patients said the procedure was not what they were expecting, but did not offer further comments. No patients said they required more information and none needed to consult other medical services. No patients were admitted outside our trust and thus our data reflect the true complication rates for our institution, with no late complications. No patients offered any suggestions for improvement in the service. We can surmise from the data that overall, the day-case procedure using local anaesthetic is well tolerated by our patients.
New techniques in CT guided lung biopsy
Newer techniques in image guided biopsy offer the potential to further improve the patient experience. Cone beam CT is a relatively new technique whereby a three dimensional CT image is generated with a rotating fluoroscopic C-arm. This has the advantage of allowing an open environment, rather than an enclosed bore CT scanner. It also allows greater flexibility in the imaging planes used, as it is not limited to the range of movement of the CT gantry, with options for computer aided navigation for needle placement. Recent studies have shown similar complication rates with cone beam CT guided lung biopsy compared with conventional CT guided procedures[3, 4, 14, 15], demonstrating equivalence in complication rates. Further modifications in CT guided biopsy technique have been shown to affect the biopsy complication rate, for example CT fluoroscopy mode versus 3 slice biopsy mode and spiral acquisition versus biopsy mode. The spiral acquisition mode generally entails a longer procedure time (and increased patient dose), thus contributing to the increased complication rate during the procedure. Our institution uses the 3 slice biopsy mode, minimising the procedure time and thereby reducing the risk of complications through the prolonged procedure time. The majority of the published studies to date are also from centres using the 3 slice biopsy mode, thus our practice is in concordance with other institutions[6, 8–11, 17–21].
Complication rates from the literature
The percentage of post-procedure pneumothorax in our patient cohort (10%) is below the average value cited in the literature in similar sized studies (15%). Likewise, our percentage of pneumothorax requiring chest drain (4%) is below the values quoted in multiple studies (5-10%)[3, 8, 9, 11, 12, 17, 18, 22–25]. Our complication rates are also in accordance with a recent large retrospective populational study including > 22,000 CT guided lung biopsies, which demonstrated a pneumothorax rate of 15%, requiring a chest drain in 6.6% of all cases. A study by Carlson et al. shows lower complication rates in CT guided lung biopsies performed in 2003–2005 compared with 1996–1998, implying a learning curve for the operator and possibly improvements in equipment. The two Consultant Radiologists performing the lung biopsies at our institution both have at least ten year experience in performing the biopsies, with no problems encountered during any potential learning curve. The study was performed over 15 months without any equipment updates; therefore this is unlikely to be a confounding factor in our study.
Whilst our study did not take into account specific factors regarding the biopsy procedure (for example, lesion size, depth, needle gauge), we assume that our patient group is comparable to the other patient groups (non-selective inclusion) and, therefore, our results are both representative and comparable. We can be reassured that our results compare favourably with the national averages. We believe we are now able to reliably inform our patients about the risks of the procedure performed at our institutions.
Our results show that there is no difference between the patient reported complication rates for pneumothorax and haemoptysis, refuting our initial hypothesis. Thus, in our patient cohort within County Durham and Darlington Foundation Trust, the hospital recorded complication rates are an accurate assessment of the true complication rates.
Subgroup of patients who sustained a pneumothorax
Size of pneumothorax
Immediate pain score/10
One week pain score/10
Shortness of breath score/10
One limitation of our study is the small patient cohort, which limits the power of the study. In addition, all patients are residents of County Durham and our data may not necessarily be representative of a different patient group, for example one within an urban area with a different demographic profile.
Our study confirms that the described procedure is safe to perform as a day-case and tolerated well by most patients. The majority of our patients felt adequately informed about the procedure. However, an area for development is to counsel about the potential for some patients to experience more prolonged post-procedural pain, with a strategy for managing this pain.
Our complication rates are commensurate with the reported rates in the literature and there is no significant difference between the patient reported rates and those obtained from retrospective review in our patient cohort. We now know the true complication rates for our institutions and can advise our patients accordingly.
Louise Capenhurst (data collection), Andrea Kay (data management), and to the following people who enabled the execution of the project: Dr. Orr (PO), Dr. Marsh, Dr. Kaabneh, Dr. Munro, Dr. Cook, Dr. Foden, Dr. Fayez and Dr. Abbassi.
This research was kindly funded by a Springboard Grant from County Durham and Darlington NHS Foundation Trust.
- Wiener RS, Schwartz LM, Woloshin S, Welch HG: Population-based risk for complications after transthoracic needle lung biopsy of a pulmonary nodule : an analysis of discharge records. Ann Intern Med. 2011, 155: 137-144. 10.7326/0003-4819-155-3-201108020-00003.PubMed CentralView ArticlePubMedGoogle Scholar
- Liu A, Southern I, Nicol E: Atrial fibrillation and pneumothorax after transthoracic needle lung biopsy. BMJ Case Reports. 2012, 2012: doi:10.1136/bcr.10.2011.4897Google Scholar
- Lee WJ, Chong S, Seo JS, Shim HJ: Transthoracic fine-needle aspiration biopsy of the lungs using a C-arm cone-beam CT system: diagnostic accuracy and post-procedural complications. Br J Radiol. 2012, 85: e217-e222. 10.1259/bjr/64727750.PubMed CentralView ArticlePubMedGoogle Scholar
- Choi JW, Park CM, Goo JM, Park YK, Sung W, Lee HJ, Lee SM, Ko JY, Shim MS: C-arm cone-beam CT-guided percutaneous transthoracic needle biopsy of small (≤20 mm) lung nodules: diagnostic accuracy and complications in 161 patients. AJR Am J Roentgenol. 2012, 199: W322-W330. 10.2214/AJR.11.7576.View ArticlePubMedGoogle Scholar
- Lim CS, Tan LE, Wang JY, Lee CH, Chang HC, Lan CC, Yang MC, Chang-Yao Tsao T, Wu YK: Risk factors of pneumothorax after CT-guided coaxial cutting needle lung biopsy through aerated versus nonaerated lung. J Vasc Interv Radiol. 2014, 25: 1209-1217. 10.1016/j.jvir.2014.03.031.View ArticlePubMedGoogle Scholar
- Boskovic T, Stanic J, Pena-Karan S, Zarogoulidis P, Drevelegas K, Katsikogiannis N, Machairiotis N, Mpakas A, Tsakiridis K, Kesisis G, Tsiouda T, Kougioumtzi I, Arikas S, Zarogoulidis K: Pneumothorax after transthoracic needle biopsy of lung lesions under CT guidance. J Thorac Dis. 2014, 6 (Suppl 1): S99-S107.PubMed CentralPubMedGoogle Scholar
- Anderson JM, Murchison J, Patel D: CT-guided lung biopsy: factors influencing diagnostic yield and complication rate. Clin Radiol. 2003, 58: 791-797. 10.1016/S0009-9260(03)00221-6.View ArticlePubMedGoogle Scholar
- Johnstone AL, Win A, Darby M, Bhartia B, Karthik S: Risks and rewards of CT-guided thoracic biopsy. Complications audit and patient experience survey. ClinRadiol. 2014, 69: S12-Google Scholar
- Richardson CM, Pointon KS, Manhire AR, Macfarlane JT: Percutaneous lung biopsies: a survey of UK practice based on 5444 biopsies. Br J Radiol. 2002, 75: 731-735. 10.1259/bjr.75.897.750731.View ArticlePubMedGoogle Scholar
- Manhire A, Charig M, Clelland C, Gleeson F, Miller R, Moss H, Pointon K, Richardson C, Sawicka E, BTS: Guidelines for radiologically guided lung biopsy. Thorax. 2003, 58: 920-936. 10.1136/thorax.58.11.920.PubMed CentralView ArticlePubMedGoogle Scholar
- Wu CC, Maher MM, Shepard J-AO: Complications of CT-guided percutaneous needle biopsy of the chest: prevention and management. AJR Am J Roentgenol. 2011, 196: W678-W682. 10.2214/AJR.10.4659.View ArticlePubMedGoogle Scholar
- Nakatani M, Tanigawa N, Kariya S, Komemushi A, Yagi R, Sawada S: Analysis of factors influencing accuracy and complications in CT-guided lung biopsy. Minim Invasive Ther Allied Technol. 2012, 21: 415-422. 10.3109/13645706.2012.662155.View ArticlePubMedGoogle Scholar
- Tsai IC, Tsai WL, Chen MC, Chang GC, Tzeng WS, Chan SW, Chen CC: CT-guided core biopsy of lung lesions: a primer. AJR Am J Roentgenol. 2009, 193: 1228-1235. 10.2214/AJR.08.2113.View ArticlePubMedGoogle Scholar
- Braak SJ, Herder GJM, van Heesewijk JPM, van Strijen MJL: Pulmonary masses: initial results of cone-beam CT guidance with needle planning software for percutaneous lung biopsy. Cardiovasc Intervent Radiol. 2012, 35: 1414-1421. 10.1007/s00270-011-0302-z.View ArticlePubMedGoogle Scholar
- Choo JY, Park CM, Lee NK, Lee SM, Lee H-J, Goo JM: Percutaneous transthoracic needle biopsy of small (≤ 1 cm) lung nodules under C-arm cone-beam CT virtual navigation guidance. Eur Radiol. 2013, 23: 712-719. 10.1007/s00330-012-2644-6.View ArticlePubMedGoogle Scholar
- Prosch H, Stadler A, Schilling M, Bürklin S, Eisenhuber E, Schober E, Mostbeck G: CT fluoroscopy-guided vs. multislice CT biopsy mode-guided lung biopsies: accuracy, complications and radiation dose. Eur J Radiol. 2012, 81: 1029-1033. 10.1016/j.ejrad.2011.01.064.View ArticlePubMedGoogle Scholar
- Carlson SK, Clayton AC: Evolution of transthoracic fine needle aspiration and core needle biopsy practice : a comparison of two time periods, 1996-1998 and 2003-2005. Diagn Cytopathol. 2011, 40: 876-881.PubMedGoogle Scholar
- LU CH, Hsiao CH, Chang YC, Lee JM, Shih JY, Wu LA, Yu CJ, Liu HM, Shih TT, Yang PC: Percutaneous computed tomography-guided coaxial core biopsy for small pulmonary lesions with ground-glass attenuation. J Thorac Oncol. 2012, 7: 143-150. 10.1097/JTO.0b013e318233d7dd.View ArticlePubMedGoogle Scholar
- Ogbole GI, Adeoye PO, Okolo CA, Iseko K: CT - guided percutaneous transthoracic lung biopsy : first experience in Ibadan, Nigeria. Niger J Clin Pract. 2013, 16: 544-547. 10.4103/1119-3077.116911.View ArticlePubMedGoogle Scholar
- Poulou LS, Tsagouli P, Ziakas PD, Politi D, Trigidou R, Thanos L: Computed tomography-guided needle aspiration and biopsy of pulmonary lesions: a single-center experience in 1000 patients. Acta Radiol. 2013, 54: 640-645. 10.1177/0284185113481595.View ArticlePubMedGoogle Scholar
- Yoshimatsu R, Yamagami T, Tanaka O, Miura H, Tanaka T, Suzuki T, Nishimura T: Comparison of fully automated and semi-automated biopsy needles for lung biopsy under CT fluoroscopic guidance. Br J Radiol. 2012, 85: 208-213. 10.1259/bjr/15132704.PubMed CentralView ArticlePubMedGoogle Scholar
- Lal H, Neyaz Z, Nath A, Borah S: CT-guided percutaneous biopsy of intrathoracic lesions. Korean J Radiol. 2012, 13: 210-226. 10.3348/kjr.2012.13.2.210.PubMed CentralView ArticlePubMedGoogle Scholar
- Khan MF, Straub R, Moghaddam SR, Maataoui A, Gurung J, Wagner TOF, Ackermann H, Thalhammer A, Vogl TJ, Jacobi V: Variables affecting the risk of pneumothorax and intrapulmonal hemorrhage in CT-guided transthoracic biopsy. Eur Radiol. 2008, 18: 1356-1363. 10.1007/s00330-008-0893-1.View ArticlePubMedGoogle Scholar
- Geraghty PR, Kee ST, McFarlane G, Razavi MK, Sze DY, Dake MD: CT - guided transthoracic Vascular and interventional radiology needle aspiration biopsy of pulmonary nodules: needle size and pneumothorax rate 1. Radiology. 2003, 229: 475-481. 10.1148/radiol.2291020499.View ArticlePubMedGoogle Scholar
- Li Y, Du Y, Yang HF, Yu JH, Xu XX: CT-guided percutaneous core needle biopsy for small (≤20 mm) pulmonary lesions. Clin Radiol. 2013, 68: e43-e48. 10.1016/j.crad.2012.09.008.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.