- Case report
- Open Access
Application of veno-arterial-venous extracorporeal membrane oxygenation in differential hypoxia
© Choi et al.; licensee BioMed Central Ltd. 2014
- Received: 21 August 2014
- Accepted: 17 October 2014
- Published: 4 November 2014
Veno-arterial extracorporeal membrane oxygenation (ECMO) through the femoral vein and artery may cause differential hypoxia, i.e., lower PaO2 in the upper body than in the lower body, because of normal cardiac output with severe impairment of pulmonary function. Hereby, we report the diagnosis and the treatment of differential hypoxia caused by veno-arterial ECMO. A 39-year-old man received cardiopulmonary resuscitation from a cardiac arrest due to acute myocardial infarction. Even after more than 30 min of resuscitation, spontaneous circulation had not resumed. Next, we performed veno-arterial ECMO through the femoral artery and vein, and the patient recovered consciousness on the second day of ECMO. On day 5 of ECMO, he lost consciousness again and presented a generalized tonic-clonic seizure, and an electroencephalogram showed delta waves suggesting diffuse cerebral cortical dysfunction. While an echocardiogram revealed improvements in myocardial function, a follow up chest radiograph showed increasing massive parenchymal infiltrations, and gas analysis of blood from the right radial artery revealed severe hypoxemia. These findings indicated a definite diagnosis of differential hypoxia, and therefore, we inserted a 17-Fr cannula into the left subclavian vein as a return cannula. The patient’s consciousness and pulmonary infiltrations were improved 2 days after veno-arterial-venous ECMO, and the electroencephalogram showed normal findings. To our knowledge, this is the first report of successful clinical management of differential hypoxia. We suggest that veno-arterial-venous ECMO could be the treatment of choice for differential hypoxia resulting from veno-arterial ECMO.
- Extracorporeal membrane oxygenation
- Pulmonary function
Femoral veno-arterial extracorporeal membrane oxygenation (VA ECMO) may cause differential hypoxia (lower PaO2 in the upper body than in the lower body, i.e., two-circulation syndrome) because of normal cardiac output with severe impairment of pulmonary function . The phenomenon of differential hypoxia has been introduced theoretically; however, to our knowledge, thus far no definitive clinical report has been published on the management of differential hypoxia.
Hereby, we report a case of differential hypoxia resulting from VA ECMO and its successful treatment using veno-arterial-venous (VAV) ECMO in a patient with respiratory failure resulting from cardiac arrest.
On the fifth day of ECMO, the patient lost consciousness again and displayed signs of generalized tonic-clonic seizure. Anticonvulsants were used immediately. The vital signs were stable, and a follow up echocardiogram revealed improvements in myocardial function and left ventricular ejection fraction (50%). A follow up chest radiograph revealed severe pulmonary edema, and arterial gas analysis of blood from the right radial artery revealed severe hypoxemia (PaO2 39 mmHg, O2 saturation 69.4%). At that time, the patient was in comatose mentality. EEG showed relatively fast beta frequency activity superimposed on delta slow waves, which implied that cerebral cortical function had further deteriorated (Figure 2B). The ventilator settings were changed as follows: pressure control mode, inspired oxygen fraction 1.0, positive end-expiratory pressure 10 cm H2O, inspiratory pressure 24 cm H2O, and respiratory rate 24 breaths/minutes. However, right radial hypoxemia did not recover.
These findings indicated a definite diagnosis of differential hypoxia, and we decided to perform VAV ECMO. A 17-Fr cannula was inserted into the left subclavian vein. Venous blood from the femoral vein was drained and oxygenated by ECMO and then perfused into the femoral artery and the left subclavian vein. The oxygenated blood entered the right atrium and bypassed the non-functioning lungs. Finally, the oxygenated blood reached the brain through the left ventricle and ascending aorta, and then right radial hypoxemia was recovered (PaO2 103 mmHg, O2 saturation 98.9%). The patient recovered consciousness and pulmonary infiltrations were improved 2 days after VAV ECMO (Figure 1D). The patient’s EEG at that time was normal (Figure 2C). ECMO and mechanical ventilator were removed 5 days after VAV ECMO. The patient was discharged 97 days after ECMO removal for rehabilitation, and followed up for 13 months without any cardiac or pulmonary problems.
ECMO is used in patients with severe cardiopulmonary failure who might otherwise die. Recent advances in catheters, bypass circuits, membrane oxygenators, and percutaneous cannulation techniques have made possible to start a closed-chest cardiopulmonary bypass outside of the operating room. Percutaneous cardiopulmonary support has produced varying degrees of success as a therapeutic option in various clinical settings, including cardiac arrest, respiratory failure, and special medical conditions [2–5].
While the benefits of ECMO are well known, awareness regarding the complications of ECMO is limited to infection, bleeding, and thrombosis [6, 7]. Bleeding and thrombosis that occur regularly during the course of ECMO can result in significant clinical complications. Surgical site bleeding, the most common source of bleeding, is reported in 6–32% of ECMO patients, with the highest incidence observed in patients who have had recent cardiac surgery . Intracranial hemorrhage, the most potentially devastating bleeding complication, occurs in 3–6% of patients. It is known that hypoxemia, acidosis, cardiovascular instability prior to initiation of ECMO, and coagulopathy increase the risk of intracranial hemorrhage .
Differential hypoxia is diagnosed on the basis of the finding of hypoxic arterial blood gas when saturations in the right radial artery are measured, which reflects the patient’s cardiac output. Because of the misconception that the lungs are unimportant while the patient is supported by VA ECMO, ventilator settings are frequently reduced to the minimum setting. Recently, Hoeper et al.  described a few images of an ECMO watershed. These images showed a watershed, where well-contrasted blood from the ECMO circuit met low-contrasted blood from the left ventricle resulting from acute pulmonary thromboembolism. Although the clinical course is similar, we think that differential hypoxia is different from ECMO watershed, because watershed is caused by a high preload (anatomical obstruction) and decreased left ventricular systolic function, whereas differential hypoxia is caused by a high afterload (physiological obstruction) and recovered left ventricular systolic function.
Variable methods to overcome differential hypoxia have only occasionally been described in the literature. These methods include the following: 1) ventilator adjustments, including increased oxygen supplementation and positive end-expiratory pressure , 2) increasing ECMO flow with full drainage of the superior vena cava , 3) inserting the arterial cannula into the carotid artery, instead of the femoral artery, or using a long cannula that could reach the aortic arch , and 4) considering central cannulation or perfusion via a subclavian vascular graft . In our patient, we employed VAV ECMO, adding a 17-Fr return venous cannula into the left subclavian vein. The oxygenated blood from the circuit of the femoral artery perfused into the left subclavian vein and then into the right atrium and pulmonary arteries. The oxygenated blood bypassed the damaged lung and perfused the coronary arteries and aortic arch (Figure 3-C). Importantly, the saturated blood entered the cerebrum and assisted recovery from hypoxic brain damage. VAV ECMO itself was not a method for left ventricular decompression. However, it supplied oxygenated blood to the vital organs in the upper body, especially the brain and myocardium, and then it presented a possibility for weaning ECMO. Simultaneous VAV ECMO and decreasing ECMO flow resulted in decreased afterload of the left ventricle. It can lead to a decrease in left atrial pressure, resulting in improvement of pulmonary edema.
Differential hypoxia has been theoretically described in the literature; however, no case involving its clinical management has been reported thus far. To our knowledge, this report is the first which describes the diagnosis and the treatment of differential hypoxia, in which hypoxic brain damage was identified through EEG monitoring and resolved with VAV ECMO. If differential hypoxia resulting from VA ECMO for myocardial infarction is left undiagnosed, it can lead to weaning failure from ECMO, which could be fatal. Therefore, during VA ECMO, saturation levels in the right radial artery must be assessed for differential hypoxia. Furthermore, we believe that VAV ECMO could be the treatment of choice for differential hypoxia resulting from VA ECMO.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Kitamura M, Shibuya M, Kurihara H, Akimoto T, Endo M, Koyanagi H: Effective cross-circulation technique of venoarterial bypass for differential hypoxia condition. Artif Organs. 1997, 21: 786-788. 10.1111/j.1525-1594.1997.tb03743.x.View ArticlePubMedGoogle Scholar
- Cardarelli MG, Young AJ, Griffith B: Use of extracorporeal membrane oxygenation for adults in cardiac arrest (E-CPR): a meta-analysis of observational studies. ASAIO J. 2009, 55: 581-586. 10.1097/MAT.0b013e3181bad907.View ArticlePubMedGoogle Scholar
- Chen YS, Chao A, Yu HY, Ko WJ, Wu IH, Chen RJ, Huang SC, Lin FY, Wang SS: Analysis and results of prolonged resuscitation in cardiac arrest patients rescued by extracorporeal membrane oxygenation. J Am Coll Cardiol. 2003, 41: 197-203.View ArticlePubMedGoogle Scholar
- Peek GJ, Mugford M, Tiruvoipati R, Wilson A, Allen E, Thalanany MM, Hibbert CL, Truesdale A, Clemens F, Cooper N, Firmin RK, Elbourne D: Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicenter randomised controlled trial. Lancet. 2009, 374: 1351-1363. 10.1016/S0140-6736(09)61069-2.View ArticlePubMedGoogle Scholar
- Lee JH, Kim SW: Successful management of warfarin-exacerbated diffuse alveolar hemorrhage using an extracorporeal membrane oxygenation. Multidiscip Respir Med. 2013, 8: 16-10.1186/2049-6958-8-16.PubMed CentralView ArticlePubMedGoogle Scholar
- Guillermo M, Alain V: Extracorporeal membrane oxygenation in adults. Cont Edu Anaesth Crit Care and Pain. 2012, 12: 57-61. 10.1093/bjaceaccp/mkr056.View ArticleGoogle Scholar
- Zangrillo A, Landoni G, Biondi ZG, Greco M, Greco T, Frati G, Patroniti N, Antonelli M, Pesenti A, Pappalardo F: A meta-analysis of complications and mortality of extracorporeal membrane oxygenation. Crit Care Resusc. 2013, 15: 172-178.PubMedGoogle Scholar
- Organization ELS: Registry Report. 2010, Ann Arbor: University of MichiganGoogle Scholar
- Bulas D, Glass P: Neonatal ECMO: neuroimaging and neurodevelopmental outcome. Seminars Perinatalogy. 2005, 29: 58-65. 10.1053/j.semperi.2005.02.009.View ArticleGoogle Scholar
- Strickland R, Frantzis P: Royal Adelaide Hospital General ICU ECMO Guidelines.http://www.icuadelaide.com.au/files/manual_ecmo.pdf.
- Min HK, Lee YT: Role of Percutaneous Cardiopulmonary Support (PCPS) in Patients with Unstable Hemodynamics During the Peri-Coronary-Intervention Period. Coronary Angiography - The Need for Improvement in Medical and Interventional Therapy. Edited by: Branislav B. 2011, Rijeka: InTech, 135-Google Scholar
- Bartlett RH, Zwischenberger JB: Management of Blood Flow and Gas Exchange during ECLS. Extracorporeal Cardiopulmonary Support in Critical Care. Edited by: Annich G, MacLaren G. 2012, Michigan: Extracorporeal Life Supporting Organization, 152-Google Scholar
- Haft J, Firmin R: Adult Cardiac Support. Extracorporeal Cardiopulmonary Support in Critical Care. Edited by: Annich G, MacLaren G. 2012, Michigan: Extracorporeal Life Supporting Organization, 327-328.Google Scholar
- Hoeper MM, Tudorache I, Kühn C, Marsch G, Hartung D, Wiesner O, Boenisch O, Haverich A, Hinrich J: Extracorporeal membrane oxygenation watershed. Circ. 2014, 130: 864-865. 10.1161/CIRCULATIONAHA.114.011677.View ArticleGoogle Scholar
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