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  1. Content type: Letter to the Editor

    It is estimated that about 60–70% of Cystic Fibrosis patients develop Pseudomonas aeruginosa chronic infection, with progressive loss of lung function, as well as increased antibiotic resistance and mortality.

    Authors: Marco Mantero, Andrea Gramegna, Giovanna Pizzamiglio, Alice D’Adda, Paolo Tarsia and Francesco Blasi

    Citation: Multidisciplinary Respiratory Medicine 2017 12:2

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  2. Content type: Original research article

    Isolated cases of pulmonary arterial hypertension (PAH) with interferon α or β therapy have been reported, but no population-based estimates of the incidence of the disease after interferon exposure are availa...

    Authors: Ravikanth Papani, Alexander G. Duarte, Yu-li Lin, Yong-Fang Kuo and Gulshan Sharma

    Citation: Multidisciplinary Respiratory Medicine 2017 12:1

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  3. Content type: Original research article

    The year 2015 marked the end of United Nations Millennium Development Goals which was aimed at halting and reversing worldwide tuberculosis (TB). The emergence of drug resistance is a major challenge for world...

    Authors: Waleed M. Sweileh, Adham S. AbuTaha, Ansam F. Sawalha, Suleiman Al-Khalil, Samah W. Al-Jabi and Sa’ed H. Zyoud

    Citation: Multidisciplinary Respiratory Medicine 2017 11:45

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  4. Content type: Original research article

    Asthma is a common disease of the airways with a significant burden for the society and for patients’ quality of life. The Social Impact of Respiratory Integrated Outcomes (SIRIO) study estimated a mean cost o...

    Authors: Roberto W. Dal Negro, Chiara Distante, Luca Bonadiman, Paola Turco and Sergio Iannazzo

    Citation: Multidisciplinary Respiratory Medicine 2016 11:44

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  5. Content type: Original research article

    We hypothesized that the use of oxygen supplementation during aerobic exercise induces less DNA damage than exercise alone.

    Authors: Andréa Lúcia Gonçalves da Silva, Thaís Evelyn Karnopp, Augusto Ferreira Weber, Cassia da Luz Goulart, Paloma de Borba Scheneiders, Dannuey Machado Cardoso, Lisiane Lisboa Carvalho, Joel Henrique Ellwanger, Lia Gonçalves Possuelo and Andréia Rosane de Moura Valim

    Citation: Multidisciplinary Respiratory Medicine 2016 11:43

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  6. Content type: Original research article

    Health-care professionals have a responsibility to be attentive to patients’ adherence behavior but it could be difficult to identify poor adherence in the context of clinical practice. Assessment of personali...

    Authors: Malin Axelsson, Linda Ekerljung, Bo Lundbäck and Jan Lötvall

    Citation: Multidisciplinary Respiratory Medicine 2016 11:42

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  7. Content type: Original research article

    Hemothorax after lung transplantation may result in increased post-operative morbidity and mortality. Risk factors for developing hemothorax and the outcomes of patients who develop hemothorax have not been we...

    Authors: Aria Hong, Christopher S. King, A. Whitney Walter Brown, Shahzad Ahmad, Oksana A. Shlobin, Sandeep Khandhar, Linda Bogar, Anthony Rongione and Steven D. Nathan

    Citation: Multidisciplinary Respiratory Medicine 2016 11:40

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  8. Content type: Original research article

    This report is based on an independent study carried out by medical professionals of the Fondazione IRCCS Istituto Nazionale dei Tumori (National Cancer Institute) in Milan, Italy, and  aimed to assess the inc...

    Authors: Carla Valenti, Paolo Pozzi, Alessandra Busia, Roberto Mazza, Paolo Bossi, Cinzia De Marco, Ario Alberto Ruprecht, Alessandro Borgini and Roberto Boffi

    Citation: Multidisciplinary Respiratory Medicine 2016 11:41

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  9. Content type: Original research article

    Coagulation abnormalities are involved in the pathogenesis of acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF). The administration of recombinant human soluble thrombomodulin (rhTM), which has bot...

    Authors: Sho Hayakawa, Yasuo Matsuzawa, Tamako Irie, Hagino Rikitake, Noriaki Okada and Yasuo Suzuki

    Citation: Multidisciplinary Respiratory Medicine 2016 11:38

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  10. Content type: Letter to the Editor

    In the absence of randomisation, observational studies must take extra care to create treatment groups that are comparable in terms of key characteristics. Various matching methods exist which can create sound...

    Authors: David B. Price, Job F. M. van Boven, Lisa M. Law, Alessandra Cifra and R. Brett McQueen

    Citation: Multidisciplinary Respiratory Medicine 2016 11:39

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  11. Content type: Review

    Despite major advances in the treatment of asthma and the development of several asthma guidelines, people still die of asthma currently. According to WHO estimates, approximately 250,000 people die prematurel...

    Authors: Gennaro D’Amato, Carolina Vitale, Antonio Molino, Anna Stanziola, Alessandro Sanduzzi, Alessandro Vatrella, Mauro Mormile, Maurizia Lanza, Giovanna Calabrese, Leonardo Antonicelli and Maria D’Amato

    Citation: Multidisciplinary Respiratory Medicine 2016 11:37

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  12. Content type: Original research article

    The aim of this study is to evaluate the presence of neurocognitive dysfunctions, depression and anxiety and the effect of positive airway pressure (PAP) therapy on these alterations in Obesity Hypoventilation...

    Authors: Serap Argun Baris, Dilek Tuncel, Cigdem Ozerdem, Huseyin Kutlu, Tugba Onyilmaz, Ilknur Basyigit, Hasim Boyaci and Fusun Yildiz

    Citation: Multidisciplinary Respiratory Medicine 2016 11:35

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  13. Content type: Original research article

    Visceral adipose tissue (VAT) was shown to be increased in patients with chronic obstructive pulmonary disease (COPD) compared to control subjects with comparable body mass index (BMI). Our aim was to determin...

    Authors: Francesca De Blasio, Erica P. A. Rutten, Emiel F. M. Wouters, Luca Scalfi, Francesco De Blasio, Marco A. Akkermans, Martijn A. Spruit and Frits M. E. Franssen

    Citation: Multidisciplinary Respiratory Medicine 2016 11:33

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  14. Content type: Original research article

    Cough is one of the most common discomforts affecting general population, which can disrupt subjects’ quality of life due to its physical, social, and psychological effects. Aim of the study was to investigate...

    Authors: Roberto W. Dal Negro, Massimiliano Mazzolini, Paola Turco and Alessandro Zanasi

    Citation: Multidisciplinary Respiratory Medicine 2016 11:34

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  15. Content type: Original research article

    Inhalation devices represent per sé critical factors because they can affect the therapeutic outcomes independently of the drug used. The role of patients’ usability and preference (PUP) for Dry Powder Inhalers (...

    Authors: Roberto W. Dal Negro and Massimiliano Povero

    Citation: Multidisciplinary Respiratory Medicine 2016 11:31

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  16. Content type: Original research article

    An increasing number of inhalation devices are presently available in the market. They are differently characterized in terms of their handling and usability, both factors which may affect the outcomes of resp...

    Authors: Roberto W. Dal Negro and Massimiliano Povero

    Citation: Multidisciplinary Respiratory Medicine 2016 11:32

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  17. Content type: Review

    Obesity is currently one of the major epidemics of this millennium and affects individuals throughout the world. It causes multiple systemic complications, some of which result in severe impairment of organs a...

    Authors: Thiago Thomaz Mafort, Rogério Rufino, Cláudia Henrique Costa and Agnaldo José Lopes

    Citation: Multidisciplinary Respiratory Medicine 2016 11:28

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  18. Content type: Original research article

    The present study reports the results of a survey jointly carried out by three Italian respiratory scientific associations (AIMAR, AIPO, SIMeR) together with an important Federation of elderly patients (FederA...

    Authors: Nicola Ciancio, Claudio M. Sanguinetti, Franco Falcone, Claudio Taranto, Roberto Fasani, Fernando De Benedetto, Onofrio Resta, Fausto De Michele, Roberto Messina, Andrea Rossi, Stefano Nardini and Giuseppe Di Maria

    Citation: Multidisciplinary Respiratory Medicine 2016 11:26

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  19. Content type: Original research article

    The air inhaled by people is abundantly populated with microorganisms which also are called bioaerosols. Bioaerosols is a colloidal suspension, formed by liquid droplets and particles of solid matter in the ai...

    Authors: Zemichael Gizaw, Mulat Gebrehiwot and Chalachew Yenew

    Citation: Multidisciplinary Respiratory Medicine 2016 11:24

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  20. Content type: Case report

    Sarcoidosis is a systemic granulomatous disease of unknown origin, characterized by the formation of granulomas without central necrosis. Each organ and tissue can be affected by the disease, but in most cases...

    Authors: Livio G. Moccia, Sabrina Castaldo, Emanuela Sirignano, Maddalena Napolitano, Enrica Barra and Alessandro Sanduzzi

    Citation: Multidisciplinary Respiratory Medicine 2016 11:27

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  21. Content type: Original research article

    Early identification and control of pathogenic bacteria are important in the treatment of pneumonia. Currently, two rapid antigen detection kits for pneumococcal pneumonia are available: one uses urine samples...

    Authors: Shoji Suzuki, Naoki Nishimura, Torahiko Jinta, Yasuhiko Yamano, Genta Ishikawa, Yutaka Tomishima, Noboru Uchiyama and Naohiko Chohnabayashi

    Citation: Multidisciplinary Respiratory Medicine 2016 11:25

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  22. Content type: Original research article

    Acute cough is one of the most frequent symptoms prompting a visit to a health care provider, usually following a viral upper respiratory tract infection (URTI). The disproportionate use of antibiotics in chil...

    Authors: Alessandro Zanasi, Luigi Lanata, Federico Saibene, Giovanni Fontana, Peter V. Dicpinigaitis, Valentina Venier and Francesco De Blasio

    Citation: Multidisciplinary Respiratory Medicine 2016 11:29

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  23. Content type: Original research article

    Dry powder inhalers (DPIs) are the most commonly used devices in asthma treatment in the Nordic countries. As new DPIs become available, patients are likely to be exposed to more than one type of device, with ...

    Authors: Birger Norderud Lærum, Gunilla Telg and Georgios Stratelis

    Citation: Multidisciplinary Respiratory Medicine 2016 11:21

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  24. Content type: Original research article

    Asthma is a disease with high cost for the National Health Service. Two of the most recent LABA/ICS combinations for persistent bronchial asthma are Beclomethasone dipropionate/Formoterol (B/F) delivered via t...

    Authors: Roberto W. Dal Negro, Chiara Distante, Luca Bonadiman, Paola Turco and Sergio Iannazzo

    Citation: Multidisciplinary Respiratory Medicine 2016 11:20

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  25. Content type: Original research article

    Hypoventilation produces or worsens respiratory acidosis in patients with hypercapnia due to acute exacerbations of chronic obstructive pulmonary disease (AECOPD). In these patients acid–base and hydroelectrol...

    Authors: Alfonso Schiavo, Maurizio Renis, Mario Polverino, Arcangelo Iannuzzi and Francesca Polverino

    Citation: Multidisciplinary Respiratory Medicine 2016 11:23

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  26. Content type: Original research article

    The present study was initiated to investigate the effectiveness, safety and tolerability of complex homeopathic CalSuli-4-02 tablets on prevention of recurrent acute upper respiratory tract infections (URTIs)...

    Authors: Miek C. Jong, Stephen L. Buskin, Lydia Ilyenko, Irina Kholodova, Julia Burkart, Stephan Weber, Thomas Keller and Petra Klement

    Citation: Multidisciplinary Respiratory Medicine 2016 11:19

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  27. Content type: Original research article

    There is limited information on prevalence of pulmonary tuberculosis (PTB) in patients with type-1-diabetes. We assessed the prevalence of PTB in patients with type-1-diabetes attending the outpatient-clinic i...

    Authors: Abilash Nair, Randeep Guleria, Devasenathipathy Kandasamy, Raju Sharma, Nikhil Tandon, Urvashi B. Singh and Ravinder Goswami

    Citation: Multidisciplinary Respiratory Medicine 2016 11:22

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  28. Content type: Review

    The inflammatory diseases of the nose, rhino-pharynx and paranasal sinuses (allergic and non allergic rhinitis, NARES; rhinosinusitis with/without nasal polyposis, adenoidal hypertrophy with/without middle ear...

    Authors: Desiderio Passali, Maria Carla Spinosi, Anna Crisanti and Luisa Maria Bellussi

    Citation: Multidisciplinary Respiratory Medicine 2016 11:18

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  29. Content type: Original research article

    Self-expandable metallic stents (SEMS) can be used to treat malignant obstructions and fistulas of the central airways. SEMS can be placed using different methods. Recently, a rigid bronchoscope has been used ...

    Authors: Cengiz Özdemir, Sinem Nedime Sökücü, Levent Karasulu, Seda Tural Önür and Levent Dalar

    Citation: Multidisciplinary Respiratory Medicine 2016 11:15

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  30. Content type: Case report

    Tracheobronchopathia Osteochondroplastica (TBPO) is an uncommon and benign condition characterized by osseous or metaplastic cartilaginous 1–3 mm nodules in the submucosa of the tracheo-bronchial tree. Posteri...

    Authors: Alessandro G. Fois, Antonella Arcadu, Luigi Santoru, Rocco Trisolini, Vincenzo Marras, Giorgio C. Ginesu, Sara Canu, Lorenzo Cordero, Gabriella Diana and Pietro Pirina

    Citation: Multidisciplinary Respiratory Medicine 2016 11:16

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  31. Content type: Original research article

    Chronic Obstructive Pulmonary Disease (COPD) is characterized by an excessive activation of the adaptive immune system and, in particular, uncontrolled expansion of the B-cell pool. One of the key promoters of...

    Authors: Francesca Polverino, Maria Laucho-Contreras, Joselyn Rojas Quintero, Miguel Divo, Victor Pinto-Plata, Lynette Sholl, Juan P. de-Torres, Bartolome R. Celli and Caroline A. Owen

    Citation: Multidisciplinary Respiratory Medicine 2016 11:17

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  32. Content type: Original research article

    Chronic respiratory diseases represent a public health challenge in both industrialized and developing countries. Chronic respiratory symptoms are more prevalent in cement factories of developing countries, wh...

    Authors: Zemichael Gizaw, Bamlaku Yifred and Takele Tadesse

    Citation: Multidisciplinary Respiratory Medicine 2016 11:13

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  33. Content type: Original research article

    Tracheal tissue engineering is a promising option for the treatment of tracheal defects. In a previous study we proved the suitability of fibrin gel as a scaffold for tracheal tissue engineering. This study in...

    Authors: Stefanie Albers, Anja Lena Thiebes, Kai L. Gessenich, Stefan Jockenhoevel and Christian G. Cornelissen

    Citation: Multidisciplinary Respiratory Medicine 2016 11:6

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  34. Content type: Review

    Asthma and chronic obstructive pulmonary disease (COPD) are frequent in the general population. These diseases can worsen the quality of life of people suffering from them, limiting their daily activities and ...

    Authors: Fabio Arpinelli, Mauro Carone, Gioacchino Riccardo and Giorgio Bertolotti

    Citation: Multidisciplinary Respiratory Medicine 2016 11:5

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  35. Content type: Reviewer acknowledgement

    The editors of Multidisciplinary Respiratory Medicine would like to thank all of our reviewers who have contributed to the journal in Volume 10 (2015).

    Authors: Fernando De Benedetto, Claudio F. Donner and Claudio M. Sanguinetti

    Citation: Multidisciplinary Respiratory Medicine 2016 11:9

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  36. Content type: Review

    Oxidants have long been recognized to have an important role in the pathogenesis of COPD, and in this cigarette smoke has a strong responsibility, because it generates a conspicuous amount of oxidant radicals ...

    Authors: Claudio M. Sanguinetti

    Citation: Multidisciplinary Respiratory Medicine 2016 11:8

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  37. Content type: Original research article

    Asthma and chronic obstructive pulmonary disease (COPD) are disorders of the lungs characterized by airflow obstruction, inflammation and tissue remodeling. Management of patients with these diseases is comple...

    Authors: Silvia Sommariva, Aureliano P. Finch and Claudio Jommi

    Citation: Multidisciplinary Respiratory Medicine 2016 11:4

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  38. Content type: Original research article

    Indoor smoking in public places and workplaces is forbidden in Italy since 2003, but some health concerns are arising from outdoor secondhand smoke (SHS) exposure for non-smokers. One of the biggest Italian St...

    Authors: Cinzia De Marco, Ario Alberto Ruprecht, Paolo Pozzi, Elena Munarini, Anna Chiara Ogliari, Roberto Mazza and Roberto Boffi

    Citation: Multidisciplinary Respiratory Medicine 2016 11:2

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    The Erratum to this article has been published in Multidisciplinary Respiratory Medicine 2016 11:11

  39. Content type: Original research article

    Chronic obstructive pulmonary disease (COPD) impairs physical status and impacts on mental health. This prospective study was designed to assess associations between mental health and systemic biomarkers, and ...

    Authors: Christian Zilz, Stefan H. Blaas, Michael Pfeifer, Rudolf A. Jörres and Stephan Budweiser

    Citation: Multidisciplinary Respiratory Medicine 2016 11:3

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  40. Content type: Review

    The major changes to our world are those involving the atmosphere and the climate, including global warming induced by anthropogenic factors, with impact on the biosphere and human environment. Studies on the ...

    Authors: Gennaro D’Amato, Carolina Vitale, Annamaria De Martino, Giovanni Viegi, Maurizia Lanza, Antonio Molino, Alessandro Sanduzzi, Alessandro Vatrella, Isabella Annesi-Maesano and Maria D’Amato

    Citation: Multidisciplinary Respiratory Medicine 2015 10:39

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  41. Content type: Original research article

    Tuberculosis (TB), Lung Cancer (LC) and Chronic Obstructive Pulmonary Diseases (COPD) affect millions of individuals worldwide. Monitoring of DNA damage in pathological situations has been investigated because...

    Authors: Andréa Lúcia Gonçalves da Silva, Maribel Josimara Bresciani, Thaís Evelyn Karnopp, Augusto Ferreira Weber, Joel Henrique Ellwanger, João Antonio Pêgas Henriques, Andréia Rosane de Moura Valim and Lia Gonçalves Possuelo

    Citation: Multidisciplinary Respiratory Medicine 2015 10:38

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